Cancer Biology Journal Club, The University of Iowa
Fall 2017, 11:30-12:30, Every Other Monday, Room B180, Med Labs
Contact: douglas-spitz@uiowa.edu Tel 319/335-8019

August 28, 2017
Presenter:  Dr. Rick Domann
Paper:Lampropoulou V, Sergushichev A, Bambouskova M, Nair S, Vincent EE, Loginicheva E, Cervantes-Barragan L, Ma X, Huang SC, Griss T, Weinheimer CJ, Khader S, Randolph GJ, Pearce EJ, Jones RG, Diwan A, Diamond MS, Artyomov MN. Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation. Cell Metab. 2016 Jul 12;24(1):158-66. doi: 10.1016/j.cmet.2016.06.004. PMCID: PMC5108454.

Related Articles:
Cordes T, Wallace M, Michelucci A, Divakaruni AS, Sapcariu SC, Sousa C, Koseki H, Cabrales P, Murphy AN, Hiller K, Metallo CM. Immunoresponsive Gene 1 and Itaconate Inhibit Succinate Dehydrogenase to Modulate Intracellular Succinate Levels. J Biol Chem. 2016 Jul 1;291(27):14274-84. doi: 10.1074/jbc.M115.685792. PMCID: PMC4933182.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4933182/


Cordes T, Michelucci A, Hiller K. Itaconic Acid: The Surprising Role of an Industrial Compound as a Mammalian Antimicrobial Metabolite. Annu Rev Nutr. 2015;35:451-73. doi: 10.1146/annurev-nutr-071714-034243. PMID: 25974697. https://doi.org/10.1146/annurev-nutr-071714-034243

Strelko CL, Lu W, Dufort FJ, Seyfried TN, Chiles TC, Rabinowitz JD, Roberts MF. Itaconic acid is a mammalian metabolite induced during macrophage activation. J Am Chem Soc. 2011 Oct 19;133(41):16386-9. doi: 10.1021/ja2070889. PMCID: PMC3216473.
http://pubs.acs.org/doi/abs/10.1021/ja2070889

Papathanassiu AE, Ko JH, Imprialou M, Bagnati M, Srivastava PK, Vu HA, Cucchi D, McAdoo SP, Ananieva EA, Mauro C, Behmoaras J. BCAT1 controls metabolic reprogramming in activated human macrophages and is associated with inflammatory diseases. Nat Commun. 2017 Jul 12;8:16040. doi: 10.1038/ncomms16040. PMCID: PMC5510229.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5510229/

Ryan DG, O'Neill LAJ. Krebs cycle rewired for macrophage and dendritic cell effector functions. FEBS Lett. 2017 Jul 7. doi: 10.1002/1873-3468.12744. [Epub ahead of print] Review.PMID: 28685841. http://onlinelibrary.wiley.com/doi/10.1002/1873-3468.12744/full
 

September 11, 2017
Presenter: Paige Kluz
Paper:  Lee SY, Jeon HM, Ju MK, Kim CH, Yoon G, Han SI, Park HG, Kang HS. Wnt/Snail signaling regulates cytochrome C oxidase and glucose metabolism. Cancer Res. 2012 Jul 15;72(14):3607-17. doi: 10.1158/0008-5472.CAN-12-0006. Epub 2012 May 25. PMID: 22637725.

Paper: Lee SY, Jeon HM, Ju MK, Jeong EK, Kim CH, Park HG, Han SI, Kang HS. Dlx-2 and glutaminase upregulate epithelial-mesenchymal transition and glycolytic switch. Oncotarget. 2016 Feb 16;7(7):7925-39. doi: 10.18632/oncotarget.6879. PMID: 26771232; PMCID: PMC4884964.

September 25, 2017
Presenter: Kelly Falls
Paper: Yuan D, Huang S, Berger E, Liu L, Gross N, Heinzmann F, Ringelhan M, Connor TO, Stadler M, Meister M, Weber J, Öllinger R, Simonavicius N, Reisinger F, Hartmann D, Meyer R, Reich M, Seehawer M, Leone V, Höchst B, Wohlleber D, Jörs S, Prinz M, Spalding D, Protzer U, Luedde T, Terracciano L, Matter M, Longerich T, Knolle P, Ried T, Keitel V, Geisler F, Unger K, Cinnamon E, Pikarsky E, Hüser N, Davis RJ, Tschaharganeh DF, Rad R, Weber A, Zender L, Haller D, Heikenwalder M. Kupffer Cell-Derived Tnf Triggers Cholangiocellular Tumorigenesis through JNK due to Chronic Mitochondrial Dysfunction and ROS. Cancer Cell. 2017 Jun 12;31(6):771-789.e6. PMID: 28609656.
doi: 10.1016/j.ccell.2017.05.006.

October 9, 2017
Presenter: Dr. Prabhat Goswami
Paper: Wang H, Nicolay BN, Chick JM, Gao X, Geng Y, Ren H, Gao H, Yang G, Williams JA, Suski JM, Keibler MA, Sicinska E, Gerdemann U, Haining WN, Roberts TM, Polyak K, Gygi SP, Dyson NJ, Sicinski P. The metabolic function of cyclin D3-CDK6 kinase in cancer cell survival. Nature. 2017 Jun 15;546(7658):426-430. PMID: 28607489; PMCID: PMC5516959.
doi: 10.1038/nature22797.

Presenter: Dr. Weizhou Zhang
Paper: Goel S, DeCristo MJ, Watt AC, BrinJones H, Sceneay J, Li BB, Khan N, Ubellacker JM, Xie S, Metzger-Filho O, Hoog J, Ellis MJ, Ma CX, Ramm S, Krop IE, Winer EP, Roberts TM, Kim HJ, McAllister SS, Zhao JJ. CDK4/6 inhibition triggers anti-tumour immunity. Nature. 2017 Aug 24;548(7668):471-475. PMID: 28813415; PMCID: PMC5570667.
doi: 10.1038/nature23465.

October 23, 2017
Presenter: Adrienne Gibson
Paper: McDonald OG, Li X, Saunders T, Tryggvadottir R, Mentch SJ, Warmoes MO, Word AE, Carrer A, Salz TH, Natsume S, Stauffer KM, Makohon-Moore A, Zhong Y, Wu H, Wellen KE, Locasale JW, Iacobuzio-Donahue CA, Feinberg AP. Epigenomic reprogramming during pancreatic cancer progression links anabolic glucose metabolism to distant metastasis. Nat Genet. 2017 Mar;49(3):367-376. PMID: 28092686.
doi: 10.1038/ng.3753.

November 6, 2016
Presenter: Sean Tompkins
Paper: Cimmino L, Dolgalev I, Wang Y, Yoshimi A, Martin GH, Wang J, Ng V, Xia B, Witkowski MT, Mitchell-Flack M, Grillo I, Bakogianni S, Ndiaye-Lobry D, Martín MT, Guillamot M, Banh RS, Xu M, Figueroa ME, Dickins RA, Abdel-Wahab O, Park CY, Tsirigos A, Neel BG, Aifantis I. Restoration of TET2 Function Blocks Aberrant Self-Renewal and Leukemia Progression. Cell. 2017 Sep 7;170(6):1079-1095.e20. PMID: 28823558.
doi: 10.1016/j.cell.2017.07.032.

November 20, 2017
Presenter:  Thanksgiving, No journal club

December 4, 2017
Presenter: Paul Akhenblit
Paper: Cantelmo AR, Conradi LC, Brajic A, Goveia J, Kalucka J, Pircher A, Chaturvedi P, Hol J, Thienpont B, Teuwen LA, Schoors S, Boeckx B, Vriens J, Kuchnio A, Veys K, Cruys B, Finotto L, Treps L, Stav-Noraas TE, Bifari F, Stapor P, Decimo I, Kampen K, De Bock K, Haraldsen G, Schoonjans L, Rabelink T, Eelen G, Ghesquière B, Rehman J, Lambrechts D, Malik AB, Dewerchin M, Carmeliet P. Inhibition of the Glycolytic Activator PFKFB3 in Endothelium Induces Tumor Vessel Normalization, Impairs Metastasis, and Improves Chemotherapy. Cancer Cell. 2016 Dec 12;30(6):968-985. PMID: 27866851.
doi: 10.1016/j.ccell.2016.10.006.