Cancer Biology Journal Club, The University of Iowa
Spring 2018, 11:30-12:30, Every Other Monday, Room B180, Med Labs
Contact: douglas-spitz@uiowa.edu Tel 319/335-8019

January 22, 2018
Presenter: Kelly Falls
Paper: Skrott Z, Mistrik M, Andersen KK, Friis S, Majera D, Gursky J, Ozdian T, Bartkova J, Turi Z, Moudry P, Kraus M, Michalova M, Vaclavkova J, Dzubak P, Vrobel I, Pouckova P, Sedlacek J, Miklovicova A, Kutt A, Li J, Mattova J, Driessen C, Dou QP, Olsen J, Hajduch M, Cvek B, Deshaies RJ, Bartek J. Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4.Nature. 2017 Dec 14;552(7684):194-199. PMID: 29211715; PMCID: PMC5730499.
doi: 10.1038/nature25016.

February 5, 2018
Presenter: Adrienne Gibson
Paper: Polireddy K, Dong R, Reed G, Yu J, Chen P, Williamson S, Violet PC, Pessetto Z, Godwin AK, Fan F, Levine M, Drisko JA, Chen Q. High Dose Parenteral Ascorbate Inhibited Pancreatic Cancer Growth and Metastasis: Mechanisms and a Phase I/IIa study. Sci Rep. 2017 Dec 7;7(1):17188. PMCID: PMC5719364. PMID: 29215048
doi:10.1038/s41598-017-17568-8.

February 19, 2018
Presenter: Dr. Douglas Spitz
Paper: Khan AA, Paget JT, McLaughlin M, Kyula JN, Wilkinson MJ, Pencavel T, Mansfield D, Roulstone V, Seth R, Halle M, Somaiah N, Boult JKR, Robinson SP, Pandha HS, Vile RG, Melcher AA, Harris PA, Harrington KJ. Genetically modified lentiviruses that preserve microvascular function protect against late radiation damage in normal tissues. Sci Transl Med. 2018 Jan 24;10(425). pii: eaar2041. PMID: 29367346.
doi: 10.1126/scitranslmed.aar2041

Supplementary Materials for Paper:
Genetically modified lentiviruses that preserve microvascular function protect against late radiation damage in normal tissues.
www.sciencetranslationalmedicine.org/cgi/content/full/10/425/eaar2041/DC1

 

March 5, 2018
Presenter: Michelle Tamplin
Paper:Behling K, Maguire WF, Di Gialleonardo V, Heeb LE, Hassan IF, Veach DR, Keshari KR, Gutin PH, Scheinberg DA, McDevitt MR. Remodeling the Vascular Microenvironment of Glioblastoma with α-Particles. J Nucl Med. 2016 Nov;57(11):1771-1777. PMCID: PMC5093034.
doi: 10.2967/jnumed.116.173559
 

March 19, 2018
Presenter: Dr. Frederick Domann
Paper: Saki M, Makino H, Javvadi P, Tomimatsu N, Ding LH, Clark JE, Gavin E, Takeda K, Andrews J, Saha D, Story MD, Burma S, Nirodi CS. EGFR Mutations Compromise Hypoxia-Associated Radiation Resistance through Impaired Replication Fork-Associated DNA Damage Repair. Mol Cancer Res. 2017 Nov;15(11):1503-1516. PMID: 28801308; PMCID: PMC5668182.
doi: 10.1158/1541-7786.MCR-17-0136.

April 2, 2018
Presenter: Dr. Xiangbing Meng
Paper:  Ingold I, Berndt C, Schmitt S, Doll S, Poschmann G, Buday K, Roveri A, Peng X, Porto Freitas F, Seibt T, Mehr L, Aichler M, Walch A, Lamp D, Jastroch M, Miyamoto S, Wurst W, Ursini F, Arnér ESJ, Fradejas-Villar N, Schweizer U, Zischka H, Friedmann Angeli JP, Conrad M. Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis. Cell. 2018 Jan 25;172(3):409-422.e21. PMID: 29290465.
doi: 10.1016/j.cell.2017.11.048. 

April 16, 2018
Presenter: Sean Tompkins
Paper: Salamanca-Cardona L, Shah H, Poot AJ, Correa FM, Di Gialleonardo V, Lui H, Miloushev VZ, Granlund KL, Tee SS, Cross JR, Thompson CB, Keshari KR. In Vivo Imaging of Glutamine Metabolism to the Oncometabolite 2-Hydroxyglutarate in IDH1/2 Mutant Tumors. Cell Metab. 2017 Dec 5;26(6):830-841.e3. PMID: 29056515; PMCID: PMC5718944.
doi: 10.1016/j.cmet.2017.10.001.

April 30 2018
Presenter: Dr. Melissa Fath
Paper: