Fall 2000

12:00-1:00, Wednesdays

Room B180, Med Labs
Contact: garry-buettner@uiowa.edu Tel 319/335-6749

August 23, 2000
Presenter: Dr. Garry Buettner
Kadiiska MB, Gladen BC, Baird DD, Dikalova AE, Sohal RS, Hatch GE, Jones DP, Mason RP, Barrett JC. (2000) Biomarkers of oxidative stress study: Are plasma antioxidants markers of CC1(4) poisoning? Free Radic Biol Med 28(6):838-845
Mecocci P, Polidori MC, Troiano L, Cherubini A, Cecchetti R, Pini G, Straatman M, Monti D, Stahl W, Sies H, Franceschi C, Senin U. (2000) Plasma antioxidants and longevity: A study on healthy centenarians. Free Radic Biol Med 28(8):1243-1248.

August 30, 2000
Presenter: Dr. Freya Schafer
Paper: Robin A. J. Smith; Carolyn M. Porteous; Carolyn V. Coulter; Michael P. Murphy (1999) Selective targeting of an antioxidant to mitochondria. European Journal of Biochemistry 263(3):709-716

September 06, 2000
Presenter: Jeanie Kirk, MPH
Paper: John J. E. Haddad and Stephen C. Land (2000) O2-evoked regulation of HIF-1a and NF-kB in perinatal lung epithelium requires glutathione biosynthesis Am J Physiol Lung Cell Mol Physiol 278:L492-L503

September 13, 2000
Presenter: Eric Kelley
Paper: James P. Fabisiak,* Vladimir A. Tyurin, Yulia Y. Tyurina, Andrey Sedlov, John S. Lazo, and Valerian E. Kagan; (2000) Nitric Oxide Dissociates Lipid Oxidation from Apoptosis and Phosphatidylserine Externalization during Oxidative Stress Biochemistry 39(1): 127-138

September 27, 2000
Presenter: Dr. Larry W. Oberley
Paper: Giovanni Pani, Barbara Bedogni, Rosanna Anzevino, Renata Colavitti, Bernardetta Palazzotti, Silvia Borrello, Tommaso Galeotti(2000) Deregulated Manganese Superoxide Dismutase Expression and Resistance to Oxidative Injury in p53-deficient Cells. Cancer Res. 60: 4654-4660

Bernardetta Palazzotti, Giovanni Pani, Renata Colavitti, Maria Emilia De Leo, Barbara Bedogni,, Silvia Borrello, Tommaso Galeotti (1999) Increased growth capacity of cervical-carcinoma cells over-expressing manganous superoxide dismutase. Int. J. Cancer 82: 145-150

October 04, 2000
Presenter: Dr. Michael Knudson
Paper: Eyal Gottlieb, Matthew G. Vander Heiden, and Craig B. Thompson(2000) Bcl-x L Prevents the Initial Decrease in Mitochondrial Membrane Potential and Subsequent Reactive Oxygen Species Production during Tumor Necrosis Factor Alpha-Induced Apoptosis Mol. Cell. Biol. 20: 5680-5689

Jerry P. Eu, Junhui Sun, Le Xu, Jonathan S. Stamler, Gerhard Meissner(2000) The Skeletal Muscle Calcium Release Channel: Coupled O2 Sensor and NO Signaling Functions Cell 102: 499-509

October 11, 2000
Presenter: Shawn Flanagan
Paper: Stefan FRANK, Heiko KÄMPFER, Maurizio PODDA, Roland KAUFMANN and Josef PFEILSCHIFTER (2000) Identification of copper/zinc superoxide dismutase as a nitric oxide-regulated gene in human (HaCaT) keratinocytes: implications for keratinocyte proliferation Biochem. J. 346: 719-728

October 18, 2000
Presenter: Krzysztof Rezka
Paper: Glaucia R. Martinez, Paolo Di Mascio, Marcelo G. Bonini, Ohara Augusto, Karlis Briviba, Helmut Sies, Patrick Maurer, Ursula Röthlisberger, Susanna Herold, Willem H. Koppenol(2000) Peroxynitrite does not decompose to singlet oxygen (1DgO2) and nitroxyl (NO-). Proc Natl Acad Sci, USA 97: 10307-10312

October 25, 2000
Presenter: Krzysztof Rezka
Paper: Ahsan Ullah Khan, Dianne Kovacic, Alexander Kolbanovskiy, Mehul Desai, Krystyna Frenkel, Nicholas E. Geacintov(2000) The decomposition of peroxynitrite to nitroxyl anion (NO-) and singlet oxygen in aqueous solution Proc Natl Acad Sci, USA 97: 2984-2989

November 01, 2000
Presenter: Maher Abdalla
Paper: Montserrat Marí, Arthur I. Cederbaum (2000) CYP2E1 Overexpression in HepG2 Cells Induces Glutathione Synthesis by Transcriptional Activation of -Glutamylcysteine Synthetase J. Biol. Chem. 275: 15563-15571

November 8, 2000
Presenter: Iman Ahmad
Paper: Jan Xu, Luming He, S. Hinan Ahmed, Sha-Wei Chen, Mark P. Goldberg, Joseph S. Beckman, Chung Y. Hsu, Costantino Iadecola (2000) Oxygen-Glucose Deprivation Induces Inducible Nitric Oxide Synthase and Nitrotyrosine Expression in Cerebral Endothelial Cells Stroke 31: 1744-1751

November 15, 2000
Presenter: Lingjie Zhao
Paper: Ana M. Rodríguez, Pauline M. Carrico, Joseph E. Mazurkiewicz, J. Andrés Meléndez (2000) Mitochondrial or cytosolic catalase reverses the MnSOD-dependent inhibition of proliferation by enhancing respiratory chain activity, net ATP production, and decreasing the steady state levels of H2O2 Free Radical Biology and Medicine 29(9): 801-813

November 29, 2000
Presenter: Dr. Garry Buettner
Paper: Fernando Antunes; Enrique Cadenas (2000) Estimation of H2O2 gradients across biomembranes FEBS Letters 475(2): 121-126

December 06, 2000
Presenter: Tongrong He
Paper: Seung-Rock Lee, Shoshana Bar-Noy, Jaeyul Kwon, Rodney L. Levine, Thressa C. Stadtman, and Sue Goo Rhee (2000) Mammalian thioredoxin reductase: Oxidation of the C-terminal cysteine/selenocysteine active site forms a thioselenide, and replacement of selenium with sulfur markedly reduces catalytic activity Proc Natl Acad Sci, USA 97: 2521-2526

December 13, 2000
Presenter: Dr. Douglas Spitz
Paper: Min Seok Seo, Sang Won Kang, Kanghwa Kim, Ivan C. Baines, Tae Hoon Lee, Sue Goo Rhee (2000) Identification of a New Type of Mammalian Peroxiredoxin That Forms an Intramolecular Disulfide as a Reaction Intermediate J. Biol. Chem. 275: 20346-20354

January 17, 2000
Presenter: Eric Kelley
Paper: Belén Beltrán, Anthony Mathur, Michael R. Duchen, Jorge D. Erusalimsky, Salvador Moncada(2000) The effect of nitric oxide on cell respiration: A key to understanding its role in cell survival or death. Proc Natl Acad Sci, USA 97: 14602-14607