Free Radical Journal Club, The University of Iowa
Fall 2021, 11:30-12:30, Mondays, Room B180, Med Labs
Contact: garry-buettner@uiowa.edu Tel 319/335-8014
 

August 30, 2021
Presenter:  Mike Petronek
Paper:  Sandoval-Acuña C, Torrealba N, Tomkova V, Jadhav SB, Blazkova K, Merta L, Lettlova S, Adamcová MK, Rosel D, Brábek J, Neuzil J, Stursa J, Werner L, Truksa J. Targeting mitochondrial iron metabolism suppresses tumor growth and metastasis by inducing mitochondrial dysfunction and mitophagy. Cancer Res. 2021 Mar 8:canres.1628.2020. Epub ahead of print. PMID: 33685989.
doi: 10.1158/0008-5472.CAN-20-1628
 

September 13, 2021
Presenter:   Dr. Garry Buettner
Paper:  Kelly FJ, Lee R, Mudway IS. Inter- and intra-individual vitamin E uptake in healthy subjects is highly repeatable across a wide supplementation dose range. Ann N Y Acad Sci. 2004 Dec;1031:22-39. PMID: 15753131.
doi: 10.1196/annals.1331.003
 

September 27, 2021
Presenter: Mike Liman
Paper: Yamamoto K, Opina A, Sail D, Blackman B, Saito K, Brender JR, Malinowski RM, Seki T, Oshima N, Crooks DR, Kishimoto S, Saida Y, Otowa Y, Choyke PL, Ardenkjær-Larsen JH, Mitchell JB, Linehan WM, Swenson RE, Krishna MC. Real-Time insight into in vivo redox status utilizing hyperpolarized [1-13C] N-acetyl cysteine. Sci Rep. 2021 Jun 9;11(1):12155. PMID: 34108512; PMCID: PMC8190077. 
doi: 10.1038/s41598-021-90921-0
 

October 11, 2021
Presenter:  Dr. Prabhat Goswami
Paper: Goncalves J, Moog S, Morin A, Gentric G, Müller S, Morrell AP, Kluckova K, Stewart TJ, Andoniadou CL, Lussey-Lepoutre C, Bénit P, Thakker A, Vettore L, Roberts J, Rodriguez R, Mechta-Grigoriou F, Gimenez-Roqueplo AP, Letouzé E, Tennant DA, Favier J. Loss of SDHB Promotes Dysregulated Iron Homeostasis, Oxidative Stress, and Sensitivity to Ascorbate. Cancer Res. 2021 Jul 1;81(13):3480-3494. Epub 2021 Jun 14.PMID: 34127497
doi: 10.1158/0008-5472.CAN-20-2936
 

October 25, 2021
Presenter: Sam Rodman 
Paper:  Luo M, Chen L, Zheng J, Wang Q, Huang Y, Liao F, Jiang Z, Zhang C, Shen G, Wu J, Wang Y, Wang Y, Leng Y, Han S, Zhang A, Wang Z, Shi C. Mitigation of radiation-induced pulmonary fibrosis by small-molecule dye IR-780. Free Radic Biol Med. 2021 Feb 20;164:417-428. Epub 2021 Jan 6. PMID: 33418112. 
doi: 10.1016/j.freeradbiomed.2020.12.435
 

November 8, 2021
Presenter:  Emily Steinbach 
Paper: Lim SW, Jin L, Luo K, Jin J, Shin YJ, Hong SY, Yang CW. Klotho enhances FoxO3-mediated manganese superoxide dismutase expression by negatively regulating PI3K/AKT pathway during tacrolimus-induced oxidative stress. Cell Death Dis. 2017 Aug 3;8(8):e2972. PMID: 28771227; PMCID: PMC5596554.
doi: 10.1038/cddis.2017.365
 

November 22, 2021
Presenter:  Thanksgiving, No journal club
Paper: 
 

December 6, 2021
Presenter:  Maddie Hines
Paper: Ansari MY, Novak K, Haqqi TM. ERK1/2-Mediated Activation of DRP1 Regulates Mitochondrial Dynamics and Apoptosis in Chondrocytes. Osteoarthritis Cartilage. 2021 Nov 9:S1063-4584(21)00962-6. Epub ahead of print. PMID: 34767958.
doi: 10.1016/j.joca.2021.11.003