FREE RADICAL JOURNAL CLUB (77:545) Fall 2020
11:30-12:30, Every Other Monday, 
Room B180 ML Conference Room
Contact:  garry-buettner@uiowa.edu   Tel 319/335-8014

Zoom Meeting: https://uiowa.zoom.us/j/96891428453?pwd=UmR6bWdqeXR2MnBjbWV3Tk1neWx5dz09
Meeting ID: 968 9142 8453
 

August 31, 2020
Presenter: Sanne Flor
Paper: Chien CH, Chuang JY, Yang ST, Yang WB, Chen PY, Hsu TI, Huang CY, Lo WL, Yang KY, Liu MS, Chu JM, Chung PH, Liu JJ, Chou SW, Chen SH, Chang KY. Enrichment of superoxide dismutase 2 in glioblastoma confers to acquisition of temozolomide resistance that is associated with tumor-initiating cell subsets. J Biomed Sci. 2019 Oct 19;26(1):77. PMID: 31629402; PMCID: PMC6800988.
doi: 10.1186/s12929-019-0565-2.
 

September 14, 2020 
Presenter: Yuna Bayanbold
Paper: Fuhrmann DC, Mondorf A, Beifuß J, Jung M, Brüne B. Hypoxia inhibits ferritinophagy, increases mitochondrial ferritin, and protects from ferroptosis. Redox Biol. 2020 Aug 3;36:101670. doi: 10.1016/j.redox.2020.101670. Epub ahead of print. PMID: 32810738; PMCID: PMC7452134.
http://doi.org/10.1016/j.redox.2020.101670  
 

September 28, 2020
Presenter: Mike Petronek
Paper: Weber RA, Yen FS, Nicholson SPV, Alwaseem H, Bayraktar EC, Alam M, Timson RC, La K, Abu-Remaileh M, Molina H, Birsoy K. Maintaining Iron Homeostasis Is the Key Role of Lysosomal Acidity for Cell Proliferation. Mol Cell. 2020 Feb 6;77(3):645-655.e7. Epub 2020 Jan 23. PMID: 31983508; PMCID: PMC7176020.
doi: 10.1016/j.molcel.2020.01.003
 

October 12, 2020
Presenter: Sam Rodman
Paper: Wang JN, Yang Q, Yang C, Cai YT, Xing T, Gao L, Wang F, Chen X, Liu XQ, He XY, Wei B, Jiang L, Li C, Jin J, Wen JG, Ma TT, Chen HY, Li J, Meng XM. Smad3 promotes AKI sensitivity in diabetic mice via interaction with p53 and induction of NOX4-dependent ROS production. Redox Biol. 2020 May;32:101479. Epub 2020 Feb 26. PMID: 32143149; PMCID: PMC7058410.
doi: 10.1016/j.redox.2020.101479.
 

October 26, 2020 
Presenter: Yuna Bayanbold
Paper: Nishizawa H, Matsumoto M, Shindo T, Saigusa D, Kato H, Suzuki K, Sato M, Ishii Y, Shimokawa H, Igarashi K. Ferroptosis is controlled by the coordinated transcriptional regulation of glutathione and labile iron metabolism by the transcription factor BACH1. J Biol Chem. 2020 Jan 3;295(1):69-82.
Epub 2019 Nov 18. PMID: 31740582; PMCID: PMC6952604.
doi: 10.1074/jbc.RA119.009548.
 

November 9, 2020
Presenter: Dr. Prabhat Goswami
Paper: Bosch M, Sánchez-Álvarez M, Fajardo A, Kapetanovic R, Steiner B, Dutra F, Moreira L, López JA, Campo R, Marí M, Morales-Paytuví F, Tort O, Gubern A, Templin RM, Curson JEB, Martel N, Català C, Lozano F, Tebar F, Enrich C, Vázquez J, Del Pozo MA, Sweet MJ, Bozza PT, Gross SP, Parton RG, Pol A. Mammalian lipid droplets are innate immune hubs integrating cell metabolism and host defense. Science. 2020 Oct 16;370(6514):eaay8085. PMID: 33060333.
doi: 10.1126/science.aay8085
 

November 23, 2020
Presenter: Thanksgiving, No journal club
 

December 7, 2020
Presenter: Dr. Douglas Spitz
Paper: McBrayer SK, Mayers JR, DiNatale GJ, Shi DD, Khanal J, Chakraborty AA, Sarosiek KA, Briggs KJ, Robbins AK, Sewastianik T, Shareef SJ, Olenchock BA, Parker SJ, Tateishi K, Spinelli JB, Islam M, Haigis MC, Looper RE, Ligon KL, Bernstein BE, Carrasco RD, Cahill DP, Asara JM, Metallo CM, Yennawar NH, Vander Heiden MG, Kaelin WG Jr. Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma. Cell. 2018 Sep 20;175(1):101-116.e25. Epub 2018 Sep 13. PMID: 30220459; PMCID: PMC6219629.
doi: 10.1016/j.cell.2018.08.038