CURRENT TOPICS IN FREE RADICAL BIOLOGY and MEDICINE
(FRRB:6006)
Fall 2022
The University of Iowa
11:30-12:30, Every Other Monday
Virtual
Contact: Dr. Corinne Griguer
corinne-griguer@uiowa.edu
August 29, 2022
Presenter: Dr. Corinne Griguer
Paper: Wyart E, Hsu MY, Sartori R, Mina E, Rausch V, Pierobon ES, Mezzanotte M, Pezzini C, Bindels LB, Lauria A, Penna F, Hirsch E, Martini M, Mazzone M, Roetto A, Geninatti Crich S, Prenen H, Sandri M, Menga A, Porporato PE. Iron supplementation is sufficient to rescue skeletal muscle mass and function in cancer cachexia. EMBO Rep. 2022 Apr 5;23(4):e53746. Epub 2022 Feb 24. PMID: 35199910; PMCID: PMC8982578.
doi: 10.15252/embr.202153746
September 12, 2022
Presenter: Mekhla Singhania
Paper:
Córdova-Delgado M, Fuentes-Retamal S, Palominos C, López-Torres C, Guzmán-Rivera D, Ramírez-Rodríguez O, Araya-Maturana R, Urra FA. FRI-1 Is an Anti-Cancer Isoquinolinequinone That Inhibits the Mitochondrial Bioenergetics and Blocks Metabolic Shifts by Redox Disruption in Breast Cancer Cells. Antioxidants (Basel). 2021 Oct 14;10(10):1618. PMID: 34679752; PMCID: PMC8533268.
doi: 10.3390/antiox10101618
September 26, 2022
Presenter: Dr. Melissa Fath
Paper: Coelho DR, Palma FR, Paviani V, He C, Danes JM, Huang Y, Calado JCP, Hart PC, Furdui CM, Poole LB, Schipma MJ, Bonini MG. Nuclear-localized, iron-bound superoxide dismutase-2 antagonizes epithelial lineage programs to promote stemness of breast cancer cells via a histone demethylase activity. Proc Natl Acad Sci U S A. 2022 Jul 19;119(29):e2110348119. Epub 2022 Jul 14. PMID: 35858297; PMCID: PMC9303987.
doi: 10.1073/pnas.2110348119
October 10, 2022
Presenter: Yuna Bayanbold
Paper: Unlu G, Prizer B, Erdal R, Yeh HW, Bayraktar EC, Birsoy K. Metabolic-scale gene activation screens identify SLCO2B1 as a heme transporter that enhances cellular iron availability. Mol Cell. 2022 Aug 4;82(15):2832-2843.e7. Epub 2022 Jun 16. PMID: 35714613; PMCID: PMC9356996.
doi: 10.1016/j.molcel.2022.05.024.
October 24, 2022
Presenter: Cancelled
Paper:
November 7, 2022
Presenter: Akshaya Warrier
Paper: Lim JKM, Delaidelli A, Minaker SW, Zhang HF, Colovic M, Yang H, Negri GL, von Karstedt S, Lockwood WW, Schaffer P, Leprivier G, Sorensen PH. Cystine/glutamate antiporter xCT (SLC7A11) facilitates oncogenic RAS transformation by preserving intracellular redox balance. Proc Natl Acad Sci U S A. 2019 May 7;116(19):9433-9442. Epub 2019 Apr 18. PMID: 31000598; PMCID: PMC6511045.
doi: 10.1073/pnas.1821323116
November 21, 2022
Presenter: Thanksgiving, No journal club
December 5, 2022
Presenter: Amanda Pope
Paper: Mason JA, Cockfield JA, Pape DJ, Meissner H, Sokolowski MT, White TC, Valentín López JC, Liu J, Liu X, Martínez-Reyes I, Chandel NS, Locasale JW, Schafer ZT. SGK1 signaling promotes glucose metabolism and survival in extracellular matrix detached cells. Cell Rep. 2021 Mar 16;34(11):108821. PMID: 33730592.
doi: 10.1016/j.celrep.2021.108821