Free Radical Journal Club, The University of Iowa
Fall 2021, 11:30-12:30, Mondays, Room B180, Med Labs
Contact: Tel 319/335-8014

January 31, 2022
Presenter: Dr. Garry Buettner

Guarino VA, Oldham WM, Loscalzo J, Zhang YY. (2019) Reaction rate of pyruvate and hydrogen peroxide: assessing antioxidant capacity of pyruvate under biological conditions. Sci Rep. 9(1):19568. PMID: 31862934; PMCID: PMC6925109.


February 14, 2022
Presenter: Yuna Bayanbold
Paper: Yambire KF, Rostosky C, Watanabe T, Pacheu-Grau D, Torres-Odio S, Sanchez-Guerrero A, Senderovich O, Meyron-Holtz EG, Milosevic I, Frahm J, West AP, Raimundo N. Impaired lysosomal acidification triggers iron deficiency and inflammation in vivo. Elife. 2019 Dec 3;8:e51031. PMID: 31793879; PMCID: PMC6917501. doi: 10.7554/eLife.51031


February 28, 2022
Presenter: Maddie Hines

Chiang S, Braidy N, Maleki S, Lal S, Richardson DR, Huang ML. Mechanisms of impaired mitochondrial homeostasis and NAD+ metabolism in a model of mitochondrial heart disease exhibiting redox active iron accumulation. Redox Biol. 2021 Oct;46:102038. Epub 2021 Jun 10. PMID: 34416478; PMCID: PMC8379503.
doi: 10.1016/j.redox.2021.102038


March 14, 2022 SPRING BREAK
No journal club


March 28, 2022 (shorter journal club)
Presenter: Dr. Garry Buettner
Paper: Fass D, Semenov SN. (2021) Previously unknown type of protein crosslink discovered. Nature. 593(7859):343-344.   PMID: 33953388 

Paper:  Wensien M, von Pappenheim FR, Funk LM, Kloskowski P, Curth U, Diederichsen U, Uranga J, Ye J, Fang P, Pan KT, Urlaub H, Mata RA, Sautner V, Tittmann K. (2021) A lysine-cysteine redox switch with an NOS bridge regulates enzyme function. Nature. 593(7859):460-464.  PMID: 33953398


April 11, 2022
Presenter: Dr. Douglas Spitz
Paper: Romani P, Nirchio N, Arboit M, Barbieri V, Tosi A, Michielin F, Shibuya S, Benoist T, Wu D, Hindmarch CCT, Giomo M, Urciuolo A, Giamogante F, Roveri A, Chakravarty P, Montagner M, Calì T, Elvassore N, Archer SL, De Coppi P, Rosato A, Martello G, Dupont S. Mitochondrial fission links ECM mechanotransduction to metabolic redox homeostasis and metastatic chemotherapy resistance. Nat Cell Biol. 2022 Feb;24(2):168-180. Epub 2022 Feb 14. PMID: 35165418.
doi: 10.1038/s41556-022-00843-w


April 25, 2022
Presenter: Dr. Rick Domann
Paper: Zweier JL, Hemann C, Kundu T, Ewees MG, Khaleel SA, Samouilov A, Ilangovan G, El-Mahdy MA. Cytoglobin has potent superoxide dismutase function. Proc Natl Acad Sci U S A. 2021 Dec 28;118(52):e2105053118. PMID: 34930834; PMCID: PMC8719900.
doi: 10.1073/pnas.2105053118