FREE RADICAL JOURNAL CLUB (FRRB:6006)

Spring 2023
Director: Corinne Griguer

The University of Iowa,

11:30 - 12:30, Every Other Monday

B180 Med Labs

 

Presentations for Spring 2023:

 

January 30, 2023

Presenter: Canceled

 

February 13, 2023

Presenter: Akshaya Warrier

Paper: Galan-Cobo A, Sitthideatphaiboon P, Qu X, Poteete A, Pisegna MA, Tong P, Chen PH, Boroughs LK, Rodriguez MLM, Zhang W, Parlati F, Wang J, Gandhi V, Skoulidis F, DeBerardinis RJ, Minna JD, Heymach JV. LKB1 and KEAP1/NRF2 Pathways Cooperatively Promote Metabolic Reprogramming with Enhanced Glutamine Dependence in KRAS-Mutant Lung Adenocarcinoma. Cancer Res. 2019 Jul 1;79(13):3251-3267. Epub 2019 Apr 30. PMID: 31040157; PMCID: PMC6606351.
doi: 10.1158/0008-5472.CAN-18-3527

 

February 27, 2023

Presenter: Kyle Current

Paper: Malone CF, Emerson C, Ingraham R, Barbosa W, Guerra S, Yoon H, Liu LL, Michor F, Haigis M, Macleod KF, Maertens O, Cichowski K. mTOR and HDAC Inhibitors Converge on the TXNIP/Thioredoxin Pathway to Cause Catastrophic Oxidative Stress and Regression of RAS-Driven Tumors. Cancer Discov. 2017 Dec;7(12):1450-1463. Epub 2017 Sep 29. PMID: 28963352; PMCID: PMC5718976.
doi: 10.1158/2159-8290.CD-17-0177

 

March 13, 2023

No journal club SPRING BREAK

 

March 27, 2023

Presenter: Dr. Douglas Spitz

Paper: Jiang H, Muir RK, Gonciarz RL, Olshen AB, Yeh I, Hann BC, Zhao N, Wang YH, Behr SC, Korkola JE, Evans MJ, Collisson EA, Renslo AR. Ferrous iron-activatable drug conjugate achieves potent MAPK blockade in KRAS-driven tumors. J Exp Med. 2022 Apr 4;219(4):e20210739. Epub 2022 Mar 9. PMID: 35262628; PMCID: PMC8916116.
doi: 10.1084/jem.20210739

 

April 10, 2023, Canceled and Rescheduled for May 8

Presenter:  Ali Razzaghi, PhD

Paper: Andrs M, Stoy H, Boleslavska B, Chappidi N, Kanagaraj R, Nascakova Z, Menon S, Rao S, Oravetzova A, Dobrovolna J, Surendranath K, Lopes M, Janscak P. Excessive reactive oxygen species induce transcription-dependent replication stress. Nat Commun. 2023 Mar 30;14(1):1791. PMID: 36997515; PMCID: PMC10063555.
doi: 10.1038/s41467-023-37341-y

 

April 24, 2023

Presenter: Sunny Huang, PhD

Paper:  Weiss-Sadan T, Ge M, Hayashi M, Gohar M, Yao CH, de Groot A, Harry S, Carlin A, Fischer H, Shi L, Wei TY, Adelmann CH, Wolf K, Vornbäumen T, Dürr BR, Takahashi M, Richter M, Zhang J, Yang TY, Vijay V, Fisher DE, Hata AN, Haigis MC, Mostoslavsky R, Bardeesy N, Papagiannakopoulos T, Bar-Peled L. NRF2 activation induces NADH-reductive stress, providing a metabolic vulnerability in lung cancer. Cell Metab. 2023 Mar 7;35(3):487-503.e7. Epub 2023 Feb 24. PMID: 36841242; PMCID: PMC9998367.
doi: 10.1016/j.cmet.2023.01.012

 

May 8, 2023

Presenter:  Ali Razzaghi, PhD

Paper: Andrs M, Stoy H, Boleslavska B, Chappidi N, Kanagaraj R, Nascakova Z, Menon S, Rao S, Oravetzova A, Dobrovolna J, Surendranath K, Lopes M, Janscak P. Excessive reactive oxygen species induce transcription-dependent replication stress. Nat Commun. 2023 Mar 30;14(1):1791. PMID: 36997515; PMCID: PMC10063555.
doi: 10.1038/s41467-023-37341-y