Cancer Biology Journal Club, The University of Iowa
Fall 2022, 11:30-12:30, Every Other Monday, Room B180, Med Labs
Contact: Tel 319/335-8019

August 22, 2022
Presenter: Cancelled


September 5, 2022

Presenter:  No journal club, Labor Day


September 19, 2022
Presenter: Mekhla Singhania
Kishimoto S, Brender JR, Chandramouli GVR, Saida Y, Yamamoto K, Mitchell JB, Krishna MC. Hypoxia-Activated Prodrug Evofosfamide Treatment in Pancreatic Ductal Adenocarcinoma Xenografts Alters the Tumor Redox Status to Potentiate Radiotherapy. Antioxid Redox Signal. 2021 Oct 10;35(11):904-915. Epub 2020 Sep 15. PMID: 32787454; PMCID: PMC8568781.
doi: 10.1089/ars.2020.8131


October 3, 2022
Presenter: Sunny Huang
Kurz E, Hirsch CA, Dalton T, Shadaloey SA, Khodadadi-Jamayran A, Miller G, Pareek S, Rajaei H, Mohindroo C, Baydogan S, Ngo-Huang A, Parker N, Katz MHG, Petzel M, Vucic E, McAllister F, Schadler K, Winograd R, Bar-Sagi D. Exercise-induced engagement of the IL-15/IL-15Rα axis promotes anti-tumor immunity in pancreatic cancer. Cancer Cell. 2022 Jul 11;40(7):720-737.e5. Epub 2022 Jun 2. PMID: 35660135; PMCID: PMC9280705.
doi: 10.1016/j.ccell.2022.05.006


October 17, 2022
Presenter: Kyle Current

Paper: Ye Q, Zhang Y, Cao Y, Wang X, Guo Y, Chen J, Horn J, Ponomareva LV, Chaiswing L, Shaaban KA, Wei Q, Anderson BD, St Clair DK, Zhu H, Leggas M, Thorson JS, She QB. Frenolicin B Targets Peroxiredoxin 1 and Glutaredoxin 3 to Trigger ROS/4E-BP1-Mediated Antitumor Effects. Cell Chem Biol. 2019 Mar 21;26(3):366-377.e12. Epub 2019 Jan 17. PMID: 30661989; PMCID: PMC6557261.
doi: 10.1016/j.chembiol.2018.11.013


October 31, 2022
Presenter: Michelle Giedt

Paper: Loo SY, Toh LP, Xie WH, Pathak E, Tan W, Ma S, Lee MY, Shatishwaran S, Yeo JZZ, Yuan J, Ho YY, Peh EKL, Muniandy M, Torta F, Chan J, Tan TJ, Sim Y, Tan V, Tan B, Madhukumar P, Yong WS, Ong KW, Wong CY, Tan PH, Yap YS, Deng LW, Dent R, Foo R, Wenk MR, Lee SC, Ho YS, Lim EH, Tam WL. Fatty acid oxidation is a druggable gateway regulating cellular plasticity for driving metastasis in breast cancer. Sci Adv. 2021 Oct 8;7(41):eabh2443. Epub 2021 Oct 6. PMID: 34613780; PMCID: PMC8494440.
doi: 10.1126/sciadv.abh2443


November 14, 2022 *Cancelled
Presenter: Ali Razzaghi


November 28, 2022
Presenter: Ali Razzaghi
Paper: Skoko JJ, Cao J, Gaboriau D, Attar M, Asan A, Hong L, Paulsen CE, Ma H, Liu Y, Wu H, Harkness T, Furdui CM, Manevich Y, Morrison CG, Brown ET, Normolle D, Spies M, Spies MA, Carroll K, Neumann CA. Redox regulation of RAD51 Cys319 and homologous recombination by peroxiredoxin 1. Redox Biol. 2022 Oct;56:102443. Epub 2022 Aug 24. PMID: 36058112; PMCID: PMC9450138.
doi: 10.1016/j.redox.2022.102443