Cancer Biology Journal Club, The University of Iowa
Apring 2022, 11:30-12:30, Every Other Monday, Room B180, Med Labs
Contact: douglas-spitz@uiowa.edu Tel 319/335-8019
January 24, 2022
Presenter: Dr. Douglas Spitz
Paper: Spinelli JB, Rosen PC, Sprenger HG, Puszynska AM, Mann JL, Roessler JM, Cangelosi AL, Henne A, Condon KJ, Zhang T, Kunchok T, Lewis CA, Chandel NS, Sabatini DM. Fumarate is a terminal electron acceptor in the mammalian electron transport chain. Science. 2021 Dec 3;374(6572):1227-1237. Epub 2021 Dec 2. PMID: 34855504.
doi: 10.1126/science.abi7495
February 7, 2022
Presenter: Sam Rodman
Paper: Liu T, Zhou L, Xiao Y, Andl T, Zhang Y. BRAF Inhibitors Reprogram Cancer-Associated Fibroblasts to Drive Matrix Remodeling and Therapeutic Escape in Melanoma. Cancer Res. 2022 Jan 21. Epub ahead of print. PMID: 35064015.
doi: 10.1158/0008-5472.CAN-21-0614
February 21, 2022
Presenter: Mike Liman
Paper: Badgley MA, Kremer DM, Maurer HC, DelGiorno KE, Lee HJ, Purohit V, Sagalovskiy IR, Ma A, Kapilian J, Firl CEM, Decker AR, Sastra SA, Palermo CF, Andrade LR, Sajjakulnukit P, Zhang L, Tolstyka ZP, Hirschhorn T, Lamb C, Liu T, Gu W, Seeley ES, Stone E, Georgiou G, Manor U, Iuga A, Wahl GM, Stockwell BR, Lyssiotis CA, Olive KP. Cysteine depletion induces pancreatic tumor ferroptosis in mice. Science. 2020 Apr 3;368(6486):85-89. PMID: 32241947; PMCID: PMC7681911.
doi: 10.1126/science.aaw9872
March 7, 2022
Presenter: Casey Pulliam
Paper: Badgley MA, Kremer DM, Maurer HC, DelGiorno KE, Lee HJ, Purohit V, Sagalovskiy IR, Ma A, Kapilian J, Firl CEM, Decker AR, Sastra SA, Palermo CF, Andrade LR, Sajjakulnukit P, Zhang L, Tolstyka ZP, Hirschhorn T, Lamb C, Liu T, Gu W, Seeley ES, Stone E, Georgiou G, Manor U, Iuga A, Wahl GM, Stockwell BR, Lyssiotis CA, Olive KP. Cysteine depletion induces pancreatic tumor ferroptosis in mice. Science. 2020 Apr 3;368(6486):85-89. PMID: 32241947; PMCID: PMC7681911.
doi: 10.1126/science.aaw9872
March 21, 2022
Presenter: Laura Pietrok
Paper: Dotsu Y, Muraoka D, Ogo N, Sonoda Y, Yasui K, Yamaguchi H, Yagita H, Mukae H, Asai A, Ikeda H. Chemical augmentation of mitochondrial electron transport chains tunes T cell activation threshold in tumors. J Immunother Cancer. 2022 Feb;10(2):e003958. PMID: 35115364; PMCID: PMC8814813.
doi: 10.1136/jitc-2021-003958
April 4, 2022
Presenter: Dr. Ali Razzaghi
Paper: Chen H, Yang H, Zhu X, Yadav T, Ouyang J, Truesdell SS, Tan J, Wang Y, Duan M, Wei L, Zou L, Levine AS, Vasudevan S, Lan L. m5C modification of mRNA serves a DNA damage code to promote homologous recombination. Nat Commun. 2020 Jun 5;11(1):2834. PMID: 32503981; PMCID: PMC7275041
doi: 10.1038/s41467-020-16722-7
April 18, 2022
Presenter: Dr. Michelle Giedt
Paper: Lin S, Huang C, Gunda V, Sun J, Chellappan SP, Li Z, Izumi V, Fang B, Koomen J, Singh PK, Hao J, Yang S. Fascin Controls Metastatic Colonization and Mitochondrial Oxidative Phosphorylation by Remodeling Mitochondrial Actin Filaments. Cell Rep. 2019 Sep 10;28(11):2824-2836.e8. PMID: 31509745; PMCID: PMC6759858.
doi: 10.1016/j.celrep.2019.08.011
May 2, 2022
Presenter: Dr. Gloria Chen
Paper: Krauß L, Urban BC, Hastreiter S, Schneider C, Wenzel P, Hassan Z, Wirth M, Lankes K, Terrasi A, Klement C, Cernilogar FM, Öllinger R, de Andrade Krätzig N, Engleitner T, Schmid RM, Steiger K, Rad R, Krämer OH, Reichert M, Schotta G, Saur D, Schneider G. HDAC2 Facilitates Pancreatic Cancer Metastasis. Cancer Res. 2022 Feb 15;82(4):695-707. PMID: 34903606.
doi: 10.1158/0008-5472.CAN-20-3209