CURRENT TOPICS IN RADIATION AND CANCER BIOLOGY (FRRB:6008)

SCHEDULE OF PRESENTATIONS

Spring 2023 (Director: Dr. Douglas Spitz)

11:30 AM - 12.30 Every Other Monday

Room B180 Med Labs

 

Presentations for Spring 2023:

 

January 16, 2023

No Journal Club, MLK Jr. Day

 

January 23, 2023

Presenter: Dr. Douglas Spitz
Paper: Crist SB, Nemkov T, Dumpit RF, Dai J, Tapscott SJ, True LD, Swarbrick A, Sullivan LB, Nelson PS, Hansen KC, Ghajar CM. Unchecked oxidative stress in skeletal muscle prevents outgrowth of disseminated tumour cells. Nat Cell Biol. 2022 Apr;24(4):538-553. Epub 2022 Apr 11. Erratum in: Nat Cell Biol. 2022 May 24;: PMID: 35411081.
doi: 10.1038/s41556-022-00881-4

 

February 6, 2023

Presenter: Mekhla Singhania

Paper: Buschhaus JM, Rajendran S, Humphries BA, Cutter AC, Muñiz AJ, Ciavattone NG, Buschhaus AM, Cañeque T, Nwosu ZC, Sahoo D, Bevoor AS, Shah YM, Lyssiotis CA, Ghosh P, Wicha MS, Rodriguez R, Luker GD. Effects of iron modulation on mesenchymal stem cell-induced drug resistance in estrogen receptor-positive breast cancer. Oncogene. 2022 Jul;41(29):3705-3718. Epub 2022 Jun 22. PMID: 35732800; PMCID: PMC9288981.
doi: 10.1038/s41388-022-02385-9

 

February 20, 2023

Presenter:  Canceled 

Paper:  

 

March 6, 2023

Presenter: Dr. Michelle Giedt, PhD

Paper: Wilcock DJ, Badrock AP, Wong CW, Owen R, Guerin M, Southam AD, Johnston H, Telfer BA, Fullwood P, Watson J, Ferguson H, Ferguson J, Lloyd GR, Jankevics A, Dunn WB, Wellbrock C, Lorigan P, Ceol C, Francavilla C, Smith MP, Hurlstone AFL. Oxidative stress from DGAT1 oncoprotein inhibition in melanoma suppresses tumor growth when ROS defenses are also breached. Cell Rep. 2022 Jun 21;39(12):110995. PMID: 35732120; PMCID: PMC9638004.
doi: 10.1016/j.celrep.2022.110995

 

March 20, 2023

Presenter: Gloria Chen

Paper: Linares J, Sallent-Aragay A, Badia-Ramentol J, Recort-Bascuas A, Méndez A, Manero-Rupérez N, Re DL, Rivas EI, Guiu M, Zwick M, Iglesias M, Martinez-Ciarpaglini C, Tarazona N, Varese M, Hernando-Momblona X, Cañellas-Socias A, Orrillo M, Garrido M, Saoudi N, Elez E, Navarro P, Tabernero J, Gomis RR, Batlle E, Pisonero J, Cervantes A, Montagut C, Calon A. Long-term platinum-based drug accumulation in cancer-associated fibroblasts promotes colorectal cancer progression and resistance to therapy. Nat Commun. 2023 Feb 10;14(1):746.  PMID: 36765091; PMCID: PMC9918738.
doi: 10.1038/s41467-023-36334-1

 

April 3, 2023

Presenter: Kyle Current

Paper: 

Rao E, Hou Y, Huang X, Wang L, Wang J, Zheng W, Yang H, Yu X, Yang K, Bugno J, Ding X, Vokes E, Fu YX, Weichselbaum RR, Liang HL. All-trans retinoic acid overcomes solid tumor radioresistance by inducing inflammatory macrophages. Sci Immunol. 2021 Jun 15;6(60):eaba8426. PMID: 34723044; PMCID: PMC8550472.
doi: 10.1126/sciimmunol.aba8426

 

April 17, 2023

Presenter:  Shravan Kannan

Paper: Hsieh RC, Krishnan S, Wu RC, Boda AR, Liu A, Winkler M, Hsu WH, Lin SH, Hung MC, Chan LC, Bhanu KR, Srinivasamani A, De Azevedo RA, Chou YC, DePinho RA, Gubin M, Vilar E, Chen CH, Slay R, Jayaprakash P, Hegde SM, Hartley G, Lea ST, Prasad R, Morrow B, Couillault CA, Steiner M, Wang CC, Venkatesulu BP, Taniguchi C, Kim YSB, Chen J, Rudqvist NP, Curran MA. ATR-mediated CD47 and PD-L1 up-regulation restricts radiotherapy-induced immune priming and abscopal responses in colorectal cancer. Sci Immunol. 2022 Jun 10;7(72):eabl9330. Epub 2022 Jun 10. PMID: 35687697; PMCID: PMC9373855.
doi: 10.1126/sciimmunol.abl9330

 

May 1, 2023

Presenter: Amanda Pope

Paper: White SM, Avantaggiati ML, Nemazanyy I, Di Poto C, Yang Y, Pende M, Gibney GT, Ressom HW, Field J, Atkins MB, Yi C. YAP/TAZ Inhibition Induces Metabolic and Signaling Rewiring Resulting in Targetable Vulnerabilities in NF2-Deficient Tumor Cells. Dev Cell. 2019 May 6;49(3):425-443.e9. PMID: 31063758; PMCID: PMC6524954.
doi: 10.1016/j.devcel.2019.04.014