My laboratory research program focuses on mechanistic studies of glioma initiation and progression, especially the contributions from the mitochondria. Over the past 10 years, as PI on several university- and NIH-funded grants, I laid the ground work in our understanding on how mitochondria play an essential role in tumor chemo-resistance and survival in glioma.
Dr. Coleman focuses his oxidative stress and mitochondrial research expertise on trying to describe redox metabolic features of articular chondrocytes that are critical to maintaining healthy articular cartilage under normal loading conditions but play a role in pathology under severe mechanical loads. Dr. Coleman has conducted substantial translational work with a focus on pathogenesis as a result of mitochondrial dysfunction and oxidative stress.
- My laboratory focuses on the transcriptional regulation of cancer related genes including oncogenes and tumor suppressor genes. Specifically, we are studying the molecular mechanisms by which aberrant cytosine methylation of CpG dinucleotides affects gene expression during the development of cancer. We have focused primarily on the tumor suppressor gene SOD2 that encodes the antioxidant enzyme superoxide dismutase. We have determined that site specific DNA methylation of the SOD2 gene promoter can suppress its transcriptional activation.
Dr. Allen is an Assistant Professor and Physician Scientist in the Department of Radiation Oncology at the University of Iowa. Dr. Allen is a redox biochemist with expertise in manipulating metabolic oxidative stress to enhance radiation and chemotherapy effectiveness and reduce associated treatment related toxicities.