Frederick Domann

Research Interests

  • My laboratory focuses on the transcriptional regulation of cancer related genes including oncogenes and tumor suppressor genes. Specifically, we are studying the molecular mechanisms by which aberrant cytosine methylation of CpG dinucleotides affects gene expression during the development of cancer. We have focused primarily on the tumor suppressor gene SOD2 that encodes the antioxidant enzyme superoxide dismutase. We have determined that site specific DNA methylation of the SOD2 gene promoter can suppress its transcriptional activation.

Apollina Goel

Research Interests

Research Interests

 

Multiple myeloma is cancer of the plasma cells and currently remains incurable. We are interested in developing novel, mechanism-based combination approaches to improve therapy responses in myeloma. For preclinical validation studies, established cell lines, co-culture models, primary tumor cells of mouse or human origin, and mouse myeloma models (transgenic and cell line derived syngeneic, orthotopic model) are being used. Currently our lab is pursuing following lines of study:

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