Fall 2008

12:00-1:00, Wednesdays

Room B180, Med Labs

Contact: garry-buettner@uiowa.edu Tel 319/335-6749

August 27
Presenter: Dr. Garry R. Buettner
Paper: Block G, Jensen CD, Morrow JD, Holland N, Norkus EP, Milne GL, Hudes M, Dalvi TB, Crawford PB, Fung EB, Schumacher L, and Harmatz P. (2008) The effect of vitamins C and E on biomarkers of oxidative stress depends on baseline level. Free Radic Biol Med. 45(4):377-384.
Found at [DOI Article]

September 3
Presenter: No journal club

September 10
Presenter: Jordan Witmer
Paper: Schulz TJ, Zarse K, Voigt A, Urban N, Birringer M, Ristow M. (2007) Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress. Cell Metab. 6(4):280-93. PMID: 17908557
Found at [DOI Article]

September 17
Presenter Canceled

September 24
Presenter: Dr. Prabhat Goswami
Paper: Hu Z, Chen J, Wei Q, Xia Y. (2008) Bidirectional actions of hydrogen peroxide on endothelial nitric-oxide synthase phosphorylation and function: Co-commitment and interplay of AKT and AMPK. J Biol Chem. 283(37):25256-25263
Found at [DOI Article]

October 1
Presenter: Jennifer Nickerson-Gass
Paper Chen C, Liu Yu, Liu R, Ikenoue T, Guan, K-L, Liu Yang, and Zhang P. (2008) TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species. J Exp Med. [Epub ahead of print] PMID: 18809716
Found at: [DOI Article]

October 8
Presenter: Dr. Garry Buettner
Paper: Zhang H, Bosch-Marce M, Shimoda LA, Tan YS, Baek JH, Wesley JB, Gonzalez FJ, Semenza GL. (2008) Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia. J Biol Chem. 283(16):10892-10903.
Found at: (DOI Article)

October 15
Presenter: Maneesh Kumar
Paper: Chun-An Chen, Lawrence J. Druhan, Saradhadevi Varadharaj, Yeong-Renn Chen, and Jay L. Zweier. (2008) Phosphorylation of Endothelial Nitric-oxide Synthase Regulates Superoxide Generation from the Enzyme*. J Bio Chem. 283(40): 27038-27047
Found at: [DOI Article]

October 22
Presenter:Tony Cyr
Paper: Montgomery et al. Maintenance of cardiac energy metabolism by histone deacetylase 3 in mice. J Clinical Investigation. Oct 1 2008. E-pub ahead of print.
Found at [DOI Article]

October 29
Presenter: Matt Fitzgerald
Paper: Ungvari Z, Labinskyy N, Gupte S, Chander PN, Edwards JG, Csiszar A. (2008) Dysregulation of mitochondrial biogenesis in vascular endothelial and smooth muscle cells of aged rats. Am J Physiol Heart Circ Physiol. 294(5):2121-2128. PMID: 18326800.
Found at: (DOI Article)

November 5
Presenter: Leena Chaudhuri
Paper: Wang C, Li Z, Lu Y, Du R, Katiyar S, Yang J, Fu M, Leader JE, Quong A, Novikoff PM, Pestell RG. (2006) Cyclin D1 repression of nuclear respiratory factor 1 integrates nuclear DNA synthesis and mitochondrial function. Proc Natl Acad Sci U S A. 103(31):11567-11572. PMID: 16864783
Found at: (DOI Article)

November 12
Presenter: Garry Buettner
Paper: Benavides GA, Squadrito GL, Mills RW, Patel HD, Isbell TS, Patel RP, Darley-Usmar VM, Doeller JE, Kraus DW. (2007) Hydrogen sulfide mediates the vasoactivity of garlic. Proc Natl Acad Sci U S A. 104(46):17977-17982. PMID: 17951430 F
ound at: [DOI Article]

November 19
Presenter: No FRJC, SFRBM Annual Meeting

November 26
Presenter: No Presenter, Thanksgiving Week

December 3
Presenter: Janice Wang
Paper: Huang Q, Wu YT, Tan HL, Ong CN, Shen HM. A novel function of poly(ADP-ribose) polymerase-1 in modulation of autophagy and necrosis under oxidative stress. Cell Death Differ. 2008. 1-14.
PMID: 18974775
Found at: [DOI Article]

December 10
Presenter: Mike Knudson
Paper: Bret R. Williams, Vineet R. Prabhu, Karen E. Hunter, Christina M. Glazier, Charles A. Whittaker, David E. Housman, Angelika Amon. (2008) Aneuploidy Affects Proliferation and Spontaneous Immortalization in Mammalian Cells. Science. 322: 703-709
Found at: [DOI Article]