Douglas Spitz's lab staff

Dr. Spitz’s laboratory is involved with the study of free radicals and oxidative stress in cancer biology from both the basic science as well as a pre-clinical translational perspective. Ongoing projects include the study of mitochondrial defects and metabolic oxidative stress in cancer biology and radiation biology, mechanisms of resistance to oxidative stress, redox regulation of signal transduction and gene expression, molecular imaging of metabolism and prediction of responses to therapy, as well as using manipulations of metabolic oxidative stress to selectively sensitize human tumors to conventional therapies that induce oxidative stress. The long term goal is to use a basic science understanding of mechanisms associated with free radical biology and oxidative stress to elucidate novel methods for manipulating outcomes significant to human health in the fields of biology and medicine relevant to cancer and other degenerative diseases associated with aging.