Free Radical Journal Club
FRRB:6006 Spring 2025
The University of Iowa
11:30 am-12:30 pm, Every Other Monday, Location Varies Based on Date

Presentations for Spring 2025:

January 27, 2025
Presenter: Garry Buettner
Paper: Carr AC, Myint PK, Vijewardane SC, Johnstone AM, Crook J, Lykkesfeldt J. An increasing proportion of the population is not covered by the current RDA for vitamin C - interrogation of EPIC-Norfolk and NHANES 2017/2018 cohorts. Crit Rev Food Sci Nutr. 2024 Jun 6:1-12. doi: 10.1080/10408398.2024.2356760. Epub ahead of print. PMID: 38845362.

Supplementary materials:

Carr AC, Vlasiuk E, Zawari M, Lunt H. Understanding the additional impact of prediabetes and type 2 diabetes mellitus on vitamin C requirements in people living with obesity. Nutr Res. 2024 Oct;130:1-10. doi: 10.1016/j.nutres.2024.08.001. Epub 2024 Aug 30. PMID: 39303359.

Dr. Buettner would also like to discuss this oral presentation: https://www.youtube.com/watch?v=dG7xtodej9c

February 10, 2025
Presenter: Kyle Current
Paper: Sharma S, Bhattarai S, Ara H, Sun G, St Clair DK, Bhuiyan MS, Kevil C, Watts MN, Dominic P, Shimizu T, McCarthy KJ, Sun H, Panchatcharam M, Miriyala S. SOD2 deficiency in cardiomyocytes defines defective mitochondrial bioenergetics as a cause of lethal dilated cardiomyopathy. Redox Biol. 2020 Oct;37:101740. doi: 10.1016/j.redox.2020.101740. Epub 2020 Sep 30. PMID: 33049519; PMCID: PMC7559509.

February 24, 2025
Presenter: Roman Mogal
Paper: Son B, Lee S, Kim H, Kang H, Jeon J, Jo S, Seong KM, Lee SJ, Youn H, Youn B. Decreased FBP1 expression rewires metabolic processes affecting aggressiveness of glioblastoma. Oncogene. 2020 Jan;39(1):36-49. doi: 10.1038/s41388-019-0974-4. Epub 2019 Aug 23. PMID: 31444412.

March 10, 2025
Presenter: Amanda Pope
Paper: Nascentes Melo LM, Sabatier M, Ramesh V, Szylo KJ, Fraser CS, Pon A, Mitchell EC, Servage KA, Allies G, Westedt IV, Cansiz F, Krystkiewicz J, Kutritz A, Schadendorf D, Morrison SJ, Ubellacker JM, Sreelatha A, Tasdogan A. Selenoprotein O Promotes Melanoma Metastasis and Regulates Mitochondrial Complex II Activity. Cancer Res. 2025 Mar 3;85(5):942-955. doi: 10.1158/0008-5472.CAN-23-2194. PMID: 39700395; PMCID: PMC11873727.

March 24, 2025 (location: 1180 ML)
Presenter: Nafis Irfan
Paper: Mir S, Ormsbee Golden BD, Griess BJ, Vengoji R, Tom E, Kosmacek EA, Oberley-Deegan RE, Talmon GA, Band V, Teoh-Fitzgerald ML. Upregulation of Nox4 induces a pro-survival Nrf2 response in cancer-associated fibroblasts that promotes tumorigenesis and metastasis, in part via Birc5 induction. Breast Cancer Res. 2022 Jul 14;24(1):48. doi: 10.1186/s13058-022-01548-6. PMID: 35836253; PMCID: PMC9281082.

April 7, 2025 (location: 1180 ML)
Presenter: Ziyu Wang
Paper: Seo MJ, Kim IY, Lee DM, Park YJ, Cho MY, Jin HJ, Choi KS. Dual inhibition of thioredoxin reductase and proteasome is required for auranofin-induced paraptosis in breast cancer cells. Cell Death Dis. 2023 Jan 19;14(1):42. doi: 10.1038/s41419-023-05586-6. PMID: 36658130; PMCID: PMC9852458.

April 21, 2025 (location: 1180 ML)
Presenter: Krishna Awasthi
Paper: van der Post S, Birchenough GMH, Held JM. NOX1-dependent redox signaling potentiates colonic stem cell proliferation to adapt to the intestinal microbiota by linking EGFR and TLR activation. Cell Rep. 2021 Apr 6;35(1):108949. doi: 10.1016/j.celrep.2021.108949. PMID: 33826887; PMCID: PMC10327654.

May 5, 2025
Presenter: Kyle Current
Paper: