Corinne Griguer, PhD
Carver College of Medicine profile
Dr. Griguer's laboratory research focuses on mechanistic studies of glioma initiation and progression, especially the contributions from the mitochondria. Over the past 10 years, as PI on several university- and NIH-funded grants, I laid the ground work in our understanding on how mitochondria play an essential role in tumor chemo-resistance and survival in glioma. My research efforts have helped to delineate how these processes are regulated at the molecular level, and we have identified Cytochrome c Oxidase as a main player in the regulation of chemo-resistance through a bioenergetic switch from glycolysis to oxidative phosphorylation.
We identified Cytochrome C Oxidase subunit 4 isoforms (COX4) as significant markers of these drastic phenotypic changes during TMZ treatment. Currently I am the PI on an ongoing NINDS funded prospective and prognostic biomarker trial which has enrolled 152 glioblastoma patients undergoing standard of care (19 clinical sites) from which cytochrome c oxidase activity is currently assayed against the standard biomarker O6-methylguanine–DNA methyltransferase.
- Primary Faculty