Joseph "Joe" Caster, MD, PhD

Assistant Professor
Carver College of Medicine profile
Select Publications
  1. Allen BG, Bodeker KL, Smith MC, Monga V, Sandhu S, Hohl R, Carlisle T, Brown H, Hollenbeck N, Vollstedt S, Greenlee JD, Howard MA, Mapuskar KA, Seyedin SN, Caster JM, Jones KA, Cullen JJ, Berg D, Wagner BA, Buettner GR, TenNapel MJ, Smith BJ, Spitz DR, Buatti JM. First in human phase 1 clinical trial of pharmacologic ascorbate combined with radiation and temozolomide for newly diagnosed glioblastoma. Clin Cancer Res 25:6590-6597, 2019. PMID: 31427282.
  2.  Petronek MS, Wagner BA, Hollenbeck NJ, Caster JM, Spitz DR, Cullen JJ, Buettner GR, Allen BG. Assessment of the stability of supraphysiological ascorbate in human blood: appropriate handling of samples from clinical trials for measurements of pharmacologic ascorbate. Radiat Res 191:491-496, 2019. PMID: 31039080.
  3. Tian X, Nguyen M, Foote HP, Caster JM, Roche KC, Peters CG, Wu P, Jayaraman L, Garmey EG, Tepper JE, Eliasof S, Wang AZ. CRLX101, a Nanoparticle-drug conjugate of camptothecin, improves rectal cancer chemoradiotherapy by inhibiting DNA repair and HIF-1α. Cancer Res 77:112-122, 2017. PMID: 27784746. 
  4. Seyedin SN, Hassibuzman MM, Callaghan C, Petronek M, Bell S, Pham V, Mapuskar K, Spitz DR, Allen BG, Caster JM. Combination therapy with PARP inhibition and hypofractionated radiation enhances responsiveness to T-cell checkpoint inhibitors in colorectal tumor models. Int J Rad Oncol Biol Phys 6:S0360-3016(20)30156-6, 2020 (epub ahead of print). PMID: 3203606. 
  5. Hopfensberger KM, Adams Q, Kim Y, Wu X, Xu W, Patwardhan K, Thammavong B, Caster J, Flynn RT. Needle-free cervical cancer treatment using helical multishield intracavitary rotating shield brachytherapy with the 169Yb isotope. Med Phys 47:2061-2071, 2020. PMID: 32073669. 
  6. Myung JH, Eblan MJ, Caster JM, Park S, Poellmann MJ, Wang K, Tepper JE, Tam KA, Miller SM, Shen C, Chen RC, Zhang T, Chera B, Wang AZ, Hong S. Multivalent binding and biomimetic cell rolling improves the sensitivity and specificity of circulating tumor cell capture. Clin Cancer Res 24:2539-2547, 2018. PMID: 29545463. 
  7. Adams Q, Hopfensperger KM, Kim Y, Wu X, Xu W, Shukla H, McGee J, Caster JM, Flynn RT.     Effectiveness of rotating-shield brachytherapy for prostate cancer dose escalation and urethral sparing. Int     J Radiat Oncol Biol Phys  102:1546-1550, 2018. PMID: 30092333.
  8. Tian, X, Lara H, Wagner KT, Saripalli S, Hyder SN, Foote M, Sethi M, Wang E, Caster JM, Zhang L, Wang AZ. Improving DNA double-strand repair inhibitor KU-55933 therapeutic index in cancer radiotherapy using nanoparticle drug delivery. Nanoscale 21:20211-9, 2015. PMID: 2657563.
  9. Au KM, Min Y, Tian X, Zhang L, Perello V, Caster JM, Wang AZ. Improving cancer chemoradiotherapy treatment by dual controlled release of docetaxel and wortmannin in polymeric nanoparticles. ACS Nano 9:8976-8996, 2015. PMID: 26267360.
  10. Caster JM, Sethi, M, Kowalski S, Wang E, Tian X, Hyder SN, Wagner KT, Zhang YA, Kapadia C, Wang AZ. Nanoparticle delivery of chemosensitizers to improve efficacy without incurring additional toxicity. Nanoscale 14:2805-2811, 2015. PMID: 25584645.
  11. Caster JM, Yu SK, Newman NJ, Patel AN, Wagner KT, Tian X, Wei T, Warner S, Wang AZ. Effects of particle size on biodistribution, efficacy, and toxicity of polymeric nanoparticles in chemoradiotherapy. Nanomedicine: NBM 13:1673-1683, 2017. PMID: 28300658.

Complete listing via Google Scholar | Pubmed

Research areas
  • Primary Faculty