Prabhat Goswami
Professor
Office: 
Free Radical & Radiation Biology Program, 4210 Medical Education and Biomedical Research Facility (MERF), The University of Iowa, Iowa City, IA 52242-1181, Fax: (319) 335-8039
Person Type: 

Research Interests

Dr. Goswami's laboratory is pursuing a mechanistic understanding of the role intracellular oxidation-reduction (redox) state plays in regulating the mammalian cell cycle, and the application of these findings in aging and cancer research as well as in response to “oxidative eustress” and “oxidative distress”. His lab discovered the presence of a redox cycle within the mammalian cell cycle that links cellular metabolism to the progression of cells through the different phases of the cell cycle. His lab also discovered a new mode of cellular aging, “chronological lifespan” which is defined as the duration during which normal cells retained their capacity to re-enter the cell cycle. Recent research efforts focus on understanding the mechanisms that contribute to enhanced proliferation and therapy resistance of cancer cells that are induced by normal cells nearing the end of their chronological lifespan.  

Additional research interests include repurposing of FDA-approved drugs for cancer therapy. Our collaborative efforts with the Department of Chemistry include chemical synthesis of mitochondria targeted antimalarial drug, artemisinin selectively to cancer versus normal cells that results in sensitization of cancer cells to standard of care therapy.  

Example Publications

Education

  • 1983 PhD, Chemistry, Gauhati University, India
  • 1976 MS, Chemistry, Gauhati University, India
  • 1974 BS with honors, Chemistry, St. Anthony's College, Shillong, India

Post-Graduate Education

  • 1978-1983 Pre-doctoral Fellow, Regional Research Laboratory, Jorhat, India
  • 1986-1988 Post-doctoral Fellow, Department of Microbiology, University of Miami, Miami, Florida