Fall 1997

12:00-1:00, Wednesdays

Room B180, Med Labs
Contact: garry-buettner@uiowa.edu Tel 319/335-6749

August 27, 1997
Presenter: Dr. Garry R. Buettner
Paper: Asahi M. et al. (1997) The oxidation of selenocysteine is involved in the inactivation of glutathione peroxidase by nitric oxide donor. J. Biol. Chem. 272:19152-19157

September 03, 1997
Presenter: Dr. Michael McCormick
Paper: Guidot et al. (1995) Mitochondrial respiration scavenges extramitochondrial superoxide anion via a nonenzymatic mechanism. J Clin Invest. 96:1131-1136.

September 10, 1997
Presenter: Dr. Shawn Flanagan
Paper: Winkelgren I. (1997) Research News: Estrogen stakes claim to cognition. Science 276:675-8. This will be discussed as background for

Behl C. et al. (1995) 17-b-Estradiol protects neurons from oxidative stress-induced cell death in vitro. BBRC 216:473-82.

September 17, 1997
Presenter: Dr. Freya Schafer
Primary paper to be discussed: Jaax et al. (1997) General guidelines for a low-fat diet effective in the management and prevention of nonmelanoma skin cancer. Nutrition and Cancer 27(2): 150-156.

This paper will be discussed only as time permits: Black et al. (1994) Effect of a low fat diet on incidence of actinic keratosis. New Engl. J. Med. 330: 1272-1275

September 24, 1997
Presenter: Eric Kelley
Paper: Rubbo H, Parthasarathy S, Barnes S, Kirk M, Kalyanaraman B, Freeman BA. (1995) Nitric Oxide Inhibition of lipoxygenase-dependent liposome and low-density lipoprotein oxidation: termination of radical chain propagation reactions and formation of nitrogen-containing oxidized lipid derivatives. Arch Biochem Biophys 324: 15-25.

October 01, 1997
Presenter: Jiqin Yang
Lander HM, et al. (1997) A molecular redox switch on p21ras: Structural basis for the nitric oxide-p21ras interaction. J. Biol Chem. 272:4323-4326.

October 08, 1997
Presenter: Dr. Ernie Lam
Paper: Anasagasti M.J., Alvarez A., Martin J.J., Mendoza L., Vidal-Vanaclocha F. (1997) Sinusoidal endothelium release of hydrogen peroxide enhances very late antigen-4-mediated melanoma cell adherence and tumor cytotoxicity during interleukin-1 promotion of hepatic melanoma metastasis in mice. Hepatology 25:840-846.

October 15, 1997
Presenter: Shijun Li
Paper: Altuvia S, Weinstein-Fischer D, Zhang A, Postow L, Storz G. (1997) A small, stable RNA induced by oxidative stress: Role as a pleiotropic regulator and antimutator. Cell, 90:43-53.

October 22, 1997
Presenter: Dr. Larry Oberley
Paper: Polyak K, Xia Y, Zweier JL, Kinzler KW, Vogelstein B. (1997) A model for p53-induced apoptosis. Nature, 389:300-305.

October 29, 1997
Presenter: Hong Wang
Paper: Liebler DC, Stratton SP, Kaysen KL (1997) Antioxidant actions of b-carotene in liposomal and microsomal membranes: Role of carotenoid-membrane incorporation and a-tocopherol. Arch. Biochem. Biophys. 338:244-250.

November 05, 1997
Presenter: Ying Zhang
Paper: Duthie SJ, Collins AR. (1997) The influence of cell growth, detoxifying enzymes and DNA repair on hydrogen peroxide-mediated DNA damage (measured using the comet assay) in human cells. Free Radic. Biol Med. 22:717-724.

November 12, 1997
Presenter: Togrong He
Jenkins DC. et al. (1995) Roles of nitric oxide in tumor growth. Proc. Natl. Acad. Sci. USA 92:4392-4396.

November 19, 1997
Presenter: Juping Zhang
Paper: Matsubara, N. et al. (1997) Possible involvement of free radical scavenging properties in the action of tumor necrosis factor-a. Free Radic Biol Med. 22:679-687.

November 26, 1997
Oxygen Society Meeting, San Francisco/Thanksgiving Holiday

December 03, 1997
Presenter: Geoff Girnun MS
Paper: Soliman MS, Cunningham ML, Morrow JD, Roberts LJ, Badr MZ. (1997) Evidence against peroxisome proliferation-induced hepatatic oxidative damage. Biochem. Pharmacology 53:1369-1374.

December 10, 1997
Presenter: Tao Yan PhD
Paper: Jahngen-Hodge, Jet al. (1997) Regulation of ubiquitin-conjugating enzymes by glutathione following oxidative stress. J. Biol. Chem. 272:28218-28226.