Fall 1999

12:00-1:00, Wednesdays

Room B180, Med Labs
Contact: garry-buettner@uiowa.edu Tel 319/335-6749

August 25, 1999
Presenter: Mike McCormick, PhD
Paper: Neufeld AH, Sawada A, Becker B. (1999) Inhibition of nitric oxide synthase 2 by aminoguanidine provides neuroprotection of retinal ganglian cells in a rat model of chronic glaucoma. PNAS 96:9944-9948.

Kaufman PL. (1999) COMMENTARY: Nitric oxide synthase and neurodegeneration/neuroprotection. PNAS 96:9455-9456.

September 01, 1999
Presenter: Larry W. Oberley, PhD
Paper: Pahan K et al. (1999) Induction of the manganese superoxide dismutsase gene by sphingomyelinase and ceramide. J Neurochem. 73:513-520.

September 08, 1999
Presenter: Garry R. Buettner, PhD
Paper: Gow AJ et al. (1999) The oxyhemoglobin reaction of nitric oxide. PNAS 96:9027-9032.

September 15, 1999
Presenter: Freya Q. Schafer, PhD
Paper: Li N, Oberley TD. (1998) Modulation of antioxidant enzymes, reactive oxygen species, and glutathione levels in manganese superoxide dismutase-overexpressing NIH/3T3 fibroblasts during the cell cycle. Journal of Cellular Physiology, 177: 148-160.

September 22, 1999
Presenter: Rick Domann, PhD
Paper: Wong A et al. (1999) The Friedreich’s ataxia mutation confers cellular sensitivity to oxidant stress which is rescued by chelators of iron and calcium and inhibitors of apoptosis. Human Molecular Genetics. 8: 425-430.

September 29, 1999
Presenter: Jeff Kirsch
Paper: Carballo M et al. (1999) Oxidative Stress Triggers STAT3 Tyrosine Phosphorylation and Nuclear Translocation in Human Lymphocytes J Biol Chem 274:17580-17586.

October 06, 1999
Presenter: Shimin (Jack) Wei
Paper: Duan H et al. (1999) SAG, a novel zinc RING finger protein that protects cells from apoptosis induced by redox agents. Molecular and Cell Biology. 19: 3145-3155.

October 13, 1999
Presenter: Meredith Preuss
Paper: Pizzimenti S et al. (1999) Inhibition of D1, D2, and a cyclin expression in HL-60 cells by the lipid peroxydation product 4-hydroxynonenal. Free Radical Biology and Medicine 11-12:1578-1586.

October 20, 1999
Presenter: Jeanie Kirk
Paper: Guo Y et al. (1999) The lat4e phase of ischemic preconditioning is abrogated by targeted disruption of the inducible NO synthase gene. PNAS 96 (20): 11507-11512.

October 27, 1999
Presenter: Dave Hall, PhD
Paper: Lee C-K et al. (1999) Gene expression profile of aging and its retardation by caloric restriction. Science 285: 1390-1393.

November 03, 1999
Presenter: Heather Adu-Sarkodie, DDS
Paper: Lauer C et al. (1999) Impairment of peroxisomal biogenesis in human colon carcinoma. Carcinogenesis 29(6):985-989.

November 10, 1999
Presenter: Eric Kelley
Paper: Eiserich JP et al. (1999) Microtubule dysfunction by postranslational nitrotyrosination of a -tubulin: a nitric oxide-dependent mechanism of cellular injury. PNAS 96: 6365-6370.

November 17, 1999
Presenter: Tongrong He
Paper: Szaski K et al. (1999) Possible role of RAC-GTPASE- activating protein in the termination of superoxide production in phagocytic cells. Free Rad Biol Med 27: 764-772.

November 24, 1999
No presentation: Thanksgiving

December 01, 1999
Presenter: Jeff Kirsch
Paper: Suh YA et al. (1999) Cell transformation by the superoxide-generating oxidase Mox1. Nature 401:79-82.

December 08, 1999
Presenter: Weiling Zhao
Paper: Fu X et al. (1999) Knockout of cellular glutathione peroxidase gene renders mice susceptible to diquat-induced oxidative stress. Free Radic Biol Med 27: 605-611.

December 15, 1999
Presenter: Garry Buettner, PhD & Freya Schafer, PhD
Paper: Di Simplicio P. (1998) Role of protein and SH groups in redox homeostasis; the erythrocyte as a model system. Arch Biochem Biophys 355: 145-152.