Fall 2009

1:00-2:00 Wednesdays

Room B180, Med Labs
Contact: garry-buettner@uiowa.edu Tel 319/335-6749

May 5, 2010
Presenter: Mitch Coleman
Paper: Gomez-Mejiba SE, Zhai Z, Gimenez MS, Ashby MT, Chilakapati J, Kitchin K, (2010) Mason RP, Ramirez DC.Myeloperoxidase-induced genomic DNA-centered radicals. J Biol Chem. [Epub ahead of print]
[DOI Article]

January 20, 2010
Presenter: canceled

January 27, 2010
Presenter: Mitch Coleman
Found at Jiang J, Stoyanovsky DA, Belikova NA, Tyurina YY, Zhao Q, Tungekar MA, Kapralova V, Huang Z, Mintz AH, Greenberger JS, Kagan VE. (2009) A mitochondria-targeted triphenylphosphonium-conjugated nitroxide functions as a radioprotector/mitigator. Radiat Res. 172(6):706-17.
Found at: [DOI Article]

February 3, 2010
Presenter: Dr. Garry R. Buettner
Paper: Reynolds JD, Ahearn GS, Angelo M, Zhang J, Cobb F, Stamler JS. (2007) S-nitrosohemoglobin deficiency: a mechanism for loss of physiological activity in banked blood. Proc Natl Acad Sci U S A. 104(43):17058-62. PMID: 17940022

Interesting scientific viewpoints on the general topic of NO and blood transfusion issues.

Paper: Gladwin MT, Kim-Shapiro DB. (2009) Storage lesion in banked blood due to hemolysis-dependent disruption of nitric oxide homeostasis. Curr Opin Hematol. 2009 Nov;16(6):515-23. PMID: 19701085

Paper: Allen BW, Stamler JS, Piantadosi CA. (2009) Hemoglobin, nitric oxide and molecular mechanisms of hypoxic vasodilation. Trends Mol Med. 15(10):452-60. PMID: 19781996

February 10, 2010
Presenter: Dr. Prabhat Goswami
Paper: Kienhöfer J, Häussler DJ, Ruckelshausen F, Muessig E, Weber K, Pimentel D, Ullrich V, Bürkle A, Bachschmid MM. (2009) Association of mitochondrial antioxidant enzymes with mitochondrial DNA as integral nucleoid constituents FASEB J. 23(7):2034-44.
[DOI Article]

February 17, 2010
Presenter: Dr. Douglas Spitz
Paper: Esteban MA, Wang T, Qin B, Yang J, Qin D, Cai J, Li W, Weng Z, Chen J, Ni S, Chen K, Li Y, Liu X, Xu J, Zhang S, Li F, He W, Labuda K, Song Y, Peterbauer A, Wolbank S, Redl H, Zhong M, Cai D, Zeng L, Pei D. (2010) Vitamin C enhances the generation of mouse and human induced pluripotent stem cells. Cell Stem Cell. 6(1):71-79.
[DOI Article]

February 24, 2010
For this week's FRJC we will participate in the

Free Radical School Virtual Seminar: Redox Signaling Through Protein Cysteine Residues

Speaker: Neil Hogg, Ph.D., Medical College of Wisconsin

Program Overview:

•General Redox signaling mechanisms – Cysteine modifications that can affect protein function (S-thiolation, oxidation, S-nitrosation, iron sulfur cluster disruption, thiyl radical formation) with a focus on thiyl radicals and Fe/S
•Examples of redox signaling mechanisms – Prokaryotic examples: Oxy R and Sox R/S as prototypic vicinal thiol and iron/S cluster targets
•YAP1 in yeast as an a process with intermediary complexity
•Higher eukaryotic examples: Nrf2/Keep1 (thiol modification leading to transcriptional regulation), ASK1/TRX (link between oxidative signaling and phosphorylation cascades to control gene expression)
•Food for thought: Gain in function vs loss of function – does 1% modification of a particular thiol matter?

The Free Radical School Virtual Seminar is sponsored by the Society for Free Radical Biology and Medicine. The Webinar will begin promptly at noon. We will be projecting the slides on our screen in Med Labs B180A.

Oh, by the way -- there will be about a dozen pizzas.

March 3, 2010
Presenter: Jaimee Eckers
Paper: Girouard H, Wang G, Gallo EF, Anrather J, Zhou P, Pickel VM, Iadecola C.
(2009) NMDA receptor activation increases free radical production through nitric oxide and NOX2. J Neurosci. 29(8):2545-52. PMID: 19244529
[DOI Article]

March 10, 2010
Presenter: Lauren Wegman
Paper: Kim A, Joseph S, Khan A, Epstein CJ, Sobel R, Huang TT. (2010) Enhanced expression of mitochondrial superoxide dismutase leads to prolonged in vivo cell cycle progression and up-regulation of mitochondrial thioredoxin. Free Radic Biol Med. [Epub ahead of print]
[DOI Article]

March 17, 2010
Presenter: No Meeting – Spring Break

March 24, 2010
Presenter: Gaowei Mao
Paper: Hoehn KL, Salmon AB, Hohnen-Behrens C, Turner N, Hoy AJ, Maghzal GJ, Stocker R, Van Remmen H, Kraegen EW, Cooney GJ, Richardson AR, James DE.
(2009) Insulin resistance is a cellular antioxidant defense mechanism. Proc Natl Acad Sci U S A. 106(42):17787-92. PMID: 19805130
[DOI Article]

March 31, 2010
Presenter: Maneesh Kumar
Paper: Liu J, Cao L, Chen J, Song S, Lee IH, Quijano C, Liu H, Keyvanfar K, Chen H, Cao LY, Ahn BH, Kumar NG, Rovira II, Xu XL, van Lohuizen M, Motoyama N, Deng CX, Finkel T.
(2009) Bmi1 regulates mitochondrial function and the DNA damage response pathway. Nature. 459(7245):387-92. PMID: 19404261
[DOI Article]

April 7, 2010
Presenter: Jennifer Nickerson-Gass
Paper: Mai S, Klinkenberg M, Auburger G, Bereiter-Hahn J, Jendrach M. (2010) Decreased expression of Drp1 and Fis1 mediates mitochondrial elongation in senescent cells and enhances resistance to oxidative stress through PINK1. J Cell Sci. 123(Pt 6):917-26.
[DOI Article]

April 14, 2010
Presenter: Jeffrey He
Paper: Aguilera-Aguirre L, Bacsi A, Saavedra-Molina A, Kurosky A, Sur S, Boldogh I. (2010) Mitochondrial dysfunction increases allergic airway inflammation. J Immunol. 183(8):5379-87.
[DOI Article]

April 21, 2010
Presenter: Tony Cyr
Paper: Wang T, Si Y, Shirihai OS, Si H, Schultz V, Corkey RF, Hu L, Deeney JT, Guo W, Corkey BE. (2009) Respiration in adipocytes is inhibited by reactive oxygen species. Obesity (Silver Spring) Epub ahead of print].
[DOI Article]

April 28, 2010
Presenter: Adam Case
Paper: Woo HA, Yim SH, Shin DH, Kang D, Yu DY, Rhee SG. (2010) Inactivation of peroxiredoxin I by phosphorylation allows localized H(2)O(2) accumulation for cell signaling. Cell. 140(4):517-28.
[DOI Article]