Fall 2012

12:00-1:00, Wednesdays

Room B180, Med Labs

Contact: garry-buettner@uiowa.edu Tel 319/335-6749


November 5, 2012
Presenter: Amanda Kalen
Paper: Mikuła-Pietrasik J, Kuczmarska A, Rubiś B, Filas V, Murias M, Zieliński P, Piwocka K, Książek K. Resveratrol delays replicative senescence of human mesothelial cells via mobilization of antioxidative and DNA repair mechanisms. Free Radic Biol Med. 2012 Jun 1-15; 52(11-12):2234-45. doi: 10.1016/j.freeradbiomed.2012.03.014. Epub 2012 Apr 30. PMID: 22579575
[DOI Article]

November 19, 2012
Presenter: Thanksgiving, No Journal Club

December 3, 2012
Presenter: Dr. Douglas Spitz
Paper: Raj L, Ide T, Gurkar AU, Foley M, Schenone M, Li X, Tolliday NJ, Golub TR, Carr SA, Shamji AF, Stern AM, Mandinova A, Schreiber SL, Lee SW. Selective killing of cancer cells by a small molecule targeting the stress response to ROS. Nature. 2011 Jul 13;475(7355):231-4. doi: 10.1038/nature10167. PMID:21753854
[DOI Article]

August 27, 2012
Presenter: Cameron Cushing
Paper: Domazou AS, Zelenay V, Koppenol WH, Gebicki JM. Efficient depletion of ascorbate by amino acid and protein radicals under oxidative stress. FRBM, (Aug 2012)
[DOI Article]

September 3, 2012
Presenter: Labor Day, no journal club

September 10, 2012
Presenter: Dr. Prabhat Goswami
Paper: Al-Mehdi AB, Pastukh VM, Swiger BM, Reed DJ, Patel MR, Bardwell GC, Pastukh VV, Alexeyev MF, Gillespie MN. Perinuclear mitochondrial clustering creates an oxidant-rich nuclear domain required for hypoxia-induced transcription. Sci Signal. 2012 Jul 3; 5(231):ra47. PMID: 22763339
[DOI Article]

Sept 24, 2012
Presenter: Trent Place
Paper: Kluza J, Corazao Rozas P, Touil Y, Jendoubi M, Maire C, Guerreschi P, Jonneaux A, Ballot C, Balayssac S, Valable S, Corroyer-Dulmont A, Bernaudin M, Malet-Martino M, Martin de Lassalle E, Maboudou P, Formstecher P, Polakowska R, Mortier L, Marchetti P. Inactivation of The HIF-1α/PDK3 Signaling Axis Drives Melanoma Toward Mitochondrial Oxidative Metabolism and Potentiates The Therapeutic Activity of Pro-oxidants. Cancer Res. 2012 Aug 3. [Epub ahead of print] PMID:22865452
[DOI Article]

October 8, 2012
Presenter: Dr. Garry Buettner
2012 In this addition of the FRJC I will present some of the new thinking by the Darley-Usmar group on redox signaling, specifically signaling by electrophiles.

Paper: Oh JY, Giles N, Landar A, Darley-Usmar V. (2008) Accumulation of 15-deoxy-delta(12,14)-prostaglandin J2 adduct formation with Keap1 over time: effects on potency for intracellular antioxidant defence induction. Biochem J411(2):297-306. PMID: 18237271
[DOI Article]

Presenter: Garry R. Buettner
Paper: Higdon A, Diers AR, Oh JY, Landar A, Darley-Usmar VM. (2012) Cell signalling by reactive lipid species: new concepts and molecular mechanisms. Biochem J442(3):453-464. Review. PMID: 22364280
[DOI Article]

October 22, 2012
Presenter: Dr. Ehab Sarsour
Paper: Hou Y, Ouyang X, Wan R, Cheng H, Mattson MP, Cheng A. Mitochondrial Superoxide Production Negatively Regulates Neural Progenitor Proliferation and Cerebral Cortical Development. Stem cells. 2012. PMID: 22949407
[DOI Article]