Fall 2015, 11:30-12:30, Mondays, Room B180, Med Labs

Contact: garry-buettner@uiowa.edu Tel 319/335-6749

September 7, 2015
Presenter: Douglas Spitz
Paper: Graham NA, Tahmasian M, Kohli B, Komisopoulou E, Zhu M, Vivanco I, Teitell MA, Wu H, Ribas A, Lo RS, Mellinghoff IK, Mischel PS, Graeber TG. Glucose deprivation activates a metabolic and signaling amplification loop leading to cell death. Mol Syst Biol. 2012 Jun 26;8:589. doi: 10.1038/msb.2012.20. PMID: 22735335; PMCID: PMC3397414.

September 7, 2015
Presenter: No FRJC, Labor Day

September 21, 2015
Presenter: Cameron Cushing
Paper: Matsumoto S, Saito K, Yasui H, Morris HD, Munasinghe JP, Lizak M, Merkle H, Ardenkjaer-Larsen JH, Choudhuri R, Devasahayam N, Subramanian S, Koretsky AP, Mitchell JB, Krishna MC. EPR oxygen imaging and hyperpolarized 13C MRI of pyruvate metabolism as noninvasive biomarkers of tumor treatment response to a glycolysis inhibitor 3-bromopyruvate. Magn Reson Med. 2013 May;69(5):1443-50. doi: 10.1002/mrm.24355. PMID: 22692861; PMCID: PMC3479339.

October 5, 2015
Presenter: Shane Solst
Paper: Andreyev AY, Tsui HS, Milne GL, Shmanai VV, Bekish AV, Fomich MA, Pham MN, Nong Y, Murphy AN, Clarke CF, Shchepinov MS. Isotope-reinforced polyunsaturated fatty acids protect mitochondria from oxidative stress. Free Radic Biol Med. 2015 May;82:63-72. doi: 10.1016/j.freeradbiomed.2014.12.023. PMID: 25578654.

October 19, 2015
Presenter: Paige Kluz
Paper: Wen JW, Hwang JT, Kelly GM. Reactive oxygen species and Wnt signaling crosstalk patterns mouse extraembryonic endoderm. Cell Signal. 2012 Dec;24(12):2337-48. doi: 10.1016/j.cellsig.2012.07.024. PMID: 22884502.

November 2, 2015
Presenter: John Lafin
Paper: Bailey AP, Koster G, Guillermier C, Hirst EM, MacRae JI, Lechene CP, Postle AD, Gould AP. Antioxidant Role for Lipid Droplets in a Stem Cell Niche of Drosophila. Cell. 2015 Oct 8;163(2):340-53. doi: 10.1016/j.cell.2015.09.020. PMID: 26451484.

November 16, 2015
Presenter: Joshua Schoenfeld
Paper: Yun J, Mullarky E, Lu C, Bosch KN, Kavalier A, Rivera K, Roper J, Chio II, Giannopoulou EG, Rago C, Muley A, Asara JM, Paik J, Elemento O, Chen Z, Pappin DJ, Dow LE, Papadopoulos N, Gross SS, Cantley LC. Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH. Science. 2015 Nov 5. pii: aaa5004. PMID: 26541605.

November 30, 2015
Presenter: Adrienne Klinger
Paper: Ameziane-El-Hassani R, Talbot M, de Souza Dos Santos MC, Al Ghuzlan A, Hartl D, Bidart JM, De Deken X, Miot F, Diallo I, de Vathaire F, Schlumberger M, Dupuy C. NADPH oxidase DUOX1 promotes long-term persistence of oxidative stress after an exposure to irradiation. Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):5051-6. doi: 10.1073/pnas.1420707112. PMID: 25848056; PMCID: PMC4413347.