CURRENT TOPICS IN FREE RADICAL BIOLOGY and MEDICINE 
Fall 2023; FRRB:6006
Mondays 11:30 am B180 Med Labs

Presentation Schedule:

Thursday, August 28, 2023
Presenter: Mekhla Singhania
Title: Mukhopadhyay S, Encarnación-Rosado J, Lin EY, Sohn ASW, Zhang H, Mancias JD, Kimmelman AC. Autophagy supports mitochondrial metabolism through the regulation of iron homeostasis in pancreatic cancer. Sci Adv. 2023 Apr 21;9(16):eadf9284. doi: 10.1126/sciadv.adf9284. PMID: 37075122; PMCID: PMC10115412.
Epub 2023 Apr 19

September 11, 2023
Presenter: Shane Solst
Paper: Luger AL, Sauer B, Lorenz NI, Engel AL, Braun Y, Voss M, Harter PN, Steinbach JP, Ronellenfitsch MW. Doxycycline Impairs Mitochondrial Function and Protects Human Glioma Cells from Hypoxia-Induced Cell Death: Implications of Using Tet-Inducible Systems. Int J Mol Sci. 2018 May 17;19(5):1504. doi: 10.3390/ijms19051504. PMID: 29772845; PMCID: PMC5983704.

Paper: Fiorillo M, Tóth F, Sotgia F, Lisanti MP. Doxycycline, Azithromycin and Vitamin C (DAV): A potent combination therapy for targeting mitochondria and eradicating cancer stem cells (CSCs). Aging (Albany NY). 2019 Apr 19;11(8):2202-2216. doi: 10.18632/aging.101905. PMID: 31002656; PMCID: PMC6520007.

September 25, 2023
Presenter: Kyle Current
Paper: Schildknecht S, von Kriegsheim A, Vujacic-Mirski K, Di Lisa F, Ullrich V, Daiber A. Recovery of reduced thiol groups by superoxide-mediated denitrosation of nitrosothiols. Redox Biol. 2022 Oct;56:102439. doi: 10.1016/j.redox.2022.102439. Epub 2022 Aug 14. PMID: 35995009; PMCID: PMC9420518

October 09, 2023
Presenter:  Melissa Fath
Paper:  Bebber CM, Thomas ES, Stroh J, Chen Z, Androulidaki A, Schmitt A, Höhne MN, Stüker L, de Pádua Alves C, Khonsari A, Dammert MA, Parmaksiz F, Tumbrink HL, Beleggia F, Sos ML, Riemer J, George J, Brodesser S, Thomas RK, Reinhardt HC, von Karstedt S. Ferroptosis response segregates small cell lung cancer (SCLC) neuroendocrine subtypes. Nat Commun. 2021 Apr 6;12(1):2048. doi: 10.1038/s41467-021-22336-4. PMID: 33824345; PMCID: PMC8024350.

October 23, 2023
Presenter: Brett Wagner
Paper: Kleschyov AL, Zhuge Z, Schiffer TA, Guimarães DD, Zhang G, Montenegro MF, Tesse A, Weitzberg E, Carlström M, Lundberg JO. NO-ferroheme is a signaling entity in the vasculature. Nat Chem Biol. 2023 Oct;19(10):1267-1275. doi: 10.1038/s41589-023-01411-5. Epub 2023 Sep 14. PMID: 37710073; PMCID: PMC10522487

November 6, 2023
Presenter: Dr. Doug Spitz
Paper: 

November 20, 2023
Presenter:  Thanksgiving, No journal club

December 4, 2023
Presenter:  Maddie Hines
Paper: Ansari MY, Ball HC, Wase SJ, Novak K, Haqqi TM. Lysosomal dysfunction in osteoarthritis and aged cartilage triggers apoptosis in chondrocytes through BAX mediated release of Cytochrome c. Osteoarthritis Cartilage. 2021 Jan;29(1):100-112. doi: 10.1016/j.joca.2020.08.014. Epub 2020 Nov 6. PMID: 33161099; PMCID: PMC8418332