Current Topics in Radical Biology and Medicine
Fall 2025; FRRB:6006
Every Other Monday, 11:30 am-12:30 pm, Room 1180 Med Labs

Presentations for Fall 2025:

September 1, 2025

No journal club, Labor Day

September 15, 2025

Presenter: Douglas Spitz

Paper: He X, Wang Q, Cheng X, Wang W, Li Y, Nan Y, Wu J, Xiu B, Jiang T, Bergholz JS, Gu H, Chen F, Fan G, Sun L, Xie S, Zou J, Lin S, Wei Y, Lee J, Asara JM, Zhang K, Cantley LC, Zhao JJ. Lysine vitcylation is a vitamin C-derived protein modification that enhances STAT1-mediated immune response. Cell. 2025 Apr 3;188(7):1858-1877.e21. doi: 10.1016/j.cell.2025.01.043. Epub 2025 Feb 28. PMID: 40023152; PMCID: PMC12308713.

September 29, 2025

Presenter: Michael Petronek

Paper: Mi XQ, Liu BC, Qu L, Yuan Y, Li H, Xu AY, Zhang YL, Xie JX, Song N. Intranasal iron administration induces iron deposition, immunoactivation, and cell-specific vulnerability in the olfactory bulb of C57BL/6 mice. Zool Res. 2025 Jan 18;46(1):209-224. doi: 10.24272/j.issn.2095-8137.2024.240. PMID: 39846197; PMCID: PMC11891001.

October 13, 2025

Presenter: Joan Whittier

Paper: Santana-Codina N, Del Rey MQ, Kapner KS, Zhang H, Gikandi A, Malcolm C, Poupault C, Kuljanin M, John KM, Biancur DE, Chen B, Das NK, Lowder KE, Hennessey CJ, Huang W, Yang A, Shah YM, Nowak JA, Aguirre AJ, Mancias JD. NCOA4-Mediated Ferritinophagy Is a Pancreatic Cancer Dependency via Maintenance of Iron Bioavailability for Iron-Sulfur Cluster Proteins. Cancer Discov. 2022 Sep 2;12(9):2180-2197. doi: 10.1158/2159-8290.CD-22-0043. PMID: 35771492; PMCID: PMC9437572.

October 27, 2025

Presenter: Roman Mogal

Paper: Patel R, Cooper DE, Kadakia KT, Allen A, Duan L, Luo L, Williams NT, Liu X, Locasale JW, Kirsch DG. Targeting glutamine metabolism improves sarcoma response to radiation therapy in vivo. Commun Biol. 2024 May 20;7(1):608. doi: 10.1038/s42003-024-06262-x. PMID: 38769385; PMCID: PMC11106276.

November 10, 2025

Presenter: Nafis Irfan

Paper: Liu WJ, Wang L, Zhou FM, Liu SW, Wang W, Zhao EJ, Yao QJ, Li W, Zhao YQ, Shi Z, Qiu JG, Jiang BH. Elevated NOX4 promotes tumorigenesis and acquired EGFR-TKIs resistance via enhancing IL-8/PD-L1 signaling in NSCLC. Drug Resist Updat. 2023 Sep;70:100987. doi: 10.1016/j.drup.2023.100987. Epub 2023 Jun 22. PMID: 37392558.

November 24, 2025

Fall Break

December 8, 2025

Presenter: Krishna Awasthi

Paper: