Spring 1996

12:00-1:00, Wednesdays

Room B180, Med Labs
Contact: garry-buettner@uiowa.edu Tel 319/335-6749

January 17, 1996
Presenter: Garry R. Buettner, PhD
Paper: Jurkett et al. (1996) Nitric oxide donors modulate ferritin and protect endothelium from oxidative injury. Free Radic. Biol. Med. 20:63-73.

January 24, 1996
Presenter: Dr. Larry W. Oberley
Paper: Yibing et al. (1995) Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase. Natr. Genetics 11:376-381.

January 31, 1996
Presenter: Rugao Liu
Paper: Gergel et al. (1995) Increased cytotoxicity of 3-morpholinosydnonimine to HepG2 cells in the presence of superoxide dismutase. J. Biol. Chem. 270:20922-20929.

February 07, 1996
Presenter: Geoff Girnun
Paper: Wiedau-Pazos et al. (1996) Mutant enzyme provides new insights into the cause of ALS and Altered reactivity of superoxide dismutase in familial amyotrophic lateral sclerosis. Sci. 271: 446-447, 515-518.

February 14, 1996
Presenter: Hannah Zhang
Paper: Asahi et al. Inactivation of glutathione peroxidase by nitric oxide. J. Biol. Chem. 270:21035-21039.

February 21, 1996
Presenter: Dr. Ernie Lam
Paper: Wetscher, G.J.; Bagchi, D.; Perdikis, G.; Bagchi, M.; Redmond, E.J.; Hinder, P.R.; Glaser, K.; Hinder, R.A. In vitro free radical production in rat esophageal mucosa induced by nicotine. Digestive Diseases and Sciences 40(4)853-858; 1995.

February 28, 1996
Presenter: Yue Qian
Paper: Zweier JL, Wang P. Samouilov A. Kuppusamy P. (1995) Enzyme-independent formation of nitric oxide in biological tissues. Nature Medicine 1:804-809.
Dr. Yebode Olakanmi,
Barisani D, Berg CL, Wessling-Resnick M, Gollan JL. (1995) Evidence for a low Km transporter for non-transferrin-bound iron in isolated rat hepatocytes. Am J Physiol 269 (Gastrointes Liver Physiol 32): G570-G576.

March 13, 1996
Presenter: Brett Wagner
Paper: Knudsen CA, Tappel AL, North JA. (1996) Multiple antioxidants protect against heme protein and lipid oxidation in kidney tissue. Free Radic Biol Med 20:165-173.

March 20, 1996
No presentation: Spring Break

March 27, 1996
Presenter: Sean Murphy, PhD
Paper: Guo FH. De Raeve HR. Rice TW. Stuehr DJ. Thunnissen FB. Erzurum SC. (1995) Continuous nitric oxide synthesis by inducible nitric oxide synthase in normal human airway epithelium in vivo. Proc. Natl. Acad. Sci. U.S. 92(17):7809-13.

April 03, 1996
Presenter: Dr. Mike McCormick
Paper: Miele ME; McGary CT; Welch DR. (1995) SOD2 (MnSOD) does not suppress tumorigenicity or metastasis of human melanoma C8161 cells. Anticancer Research 15:2065-2070.

April 10, 1996
Presenter: Dr. Rick Domann
Paper: Robertson GP; Coleman AB; Lugo TG (1996) Mechanisms of human melanoma cell growth and tumor suppression by chromosome 6. Cancer Res. 56:1635-41.

April 17, 1996
Presenter: Dr. Steve Hempel
Paper: Conte D; Narindrasorasak S; Sarkar B. (1996) In vivo and in vitro iron replaced zinc finger generates free radicals and causes DNA damage. J. Biol. Chem. 271:5125-5130.

April 24, 1996
Presenter: Eric E, Kelley
Paper: Traber MG; Packer L. (1995) Vitamin E: beyound antioxidant function. Am. J. Clin. Nutr. 62(Suppl):1501S-9S. and Azzi A; et al. (19965) Vitamin E: a sensor and an information transducer of the cell oxidation state. Am. J. Clin. Nutr. 62(Suppl):1337S-46S.

May 01, 1996
Presenter: Dr. Tom Shires
Paper: Sun, Y; Oberley, LW. (1996) Redox regulation of transcriptional activators. Free Radical Biol. Med., in press. and Autor AP. (1982) Biosynthesis of mitochondrial manganese superoxide dismutase in saccharomyces cerecisiae; precursor form of mitochondrial superoxide dismutase made in the cytoplasm. J. Biol. Chem. 257:2713-2718.

May 08, 1996
Presenter: Garry R. Buettner, PhD
Paper: Poderoso et al. (1996) Nitric oxide inhibits electron transfer and increases superoxide radical production in rat heart mitochondria and submitochondrial particles. Archives Biochemistry and Biophysics 328:85-92.