Spring 1999

12:00-1:00, Wednesdays

Room B180, Med Labs
Contact: garry-buettner@uiowa.edu Tel 319/335-6749

January 20, 1999
Presenter: Mike McCormick, PhD
Paper: Raff M. (1998) Cell suicide for beginners. Nature 396: 119-122.

Fadeel B et al. (1998) Involvement of caspases in neutrophil apoptosis: regulation by reactive oxygen species. Blood 92: 4808-4818.

January 27, 1999
Presenter: Shawn Flanagan, PhD
Paper: Bredt DS. (1998) NO skeletal muscle derived relaxing factor in Duchenne muscular dystrophy. Proc Natl Acad Sci 95: 14592-14593.

Thomas GD et al. (1998) Impaired metabolic modulation of a -adrenergic vasoconstriction in dystrophin-deficient skeletal muscle. Proc Natl Acad Sci 95: 15090-15095.

February 03, 1999
Presenter: Dave Hall, PhD
Paper:Lee SM and Park J-W. (1998) Thermosensitive phenotype of yeast mutant lacking thioredoxin peroxidase. Arch Biochem Biophys 359: 99-106.

February 10, 1999
Presenter: Larry Oberley, PhD
Paper: Preville X et al. (1998) Analysis of the role of Hsp25 phosphorylation reveals the importance of the oligomerization state of this small heat shock protein in its protective function against TNFa - and hydrogen peroxide-induced cell death. J Cellular Biochem 69: 436-452.

February 17, 1999
Presenter: Jeff Kirsch
Paper: Ueda S et al. (1998) Redox regulation of caspase-3(-like) protease activity: regulatory roles of thioredoxin and cytochrome c1. J Immunology 161: 6689-6695.

February 24, 1999
Presenter: Shijun Li
Paper: Tian W-N et al. (1998) Importance of glucose-6-phosphate dehydrogenase activity for cell growth. J Biol Chem 273: 10609-10617.

March 03, 1999
Presenter: Tongrong He
Paper: Luo Y et al. (1998) Dopamine induces apoptosis through an oxidation-involved SAPK-JNK activation pathway. J Biol Chem 273: 3756-3764.

March 10, 1999
Presenter: Heather Adu-Sarkodie, DDS
Paper: Bhagwat SV et al. (1998) Preferential effects of nicotine and 4-(N-Methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone on mitochondrial glutathione S-transferase A4-4 induction and increased oxidative stress in the rat brain. Biochem Pharmacol 56: 831-839.

March 17, 1999
No Presentation: Spring Break

March 24, 1999
Presenter: Hong Duan
Paper: Jakob U et al. (1999) Chaperone activity with a redox switch. Cell 96: 341-352.

March 31, 1999
Presenter: Freya Schafer, PhD
Paper: Houston M et al. (1999) Binding of xanthine oxidase to vascular endothelium. J Biol Chem 274: 4985-4994.

April 07, 1999
Presenter: Garry Buettner, PhD
Paper: Smith CV et al. (1996) Compartmentation of glutathione: implications for the study of toxicity and disease. Toxicol Appl Pharmaco. 140: 1-11.

Samiec PS et al. (1998) Glutathione in human plasma: decline in association with aging, age-related macular degeneration, and diabetes. Free Radical Biol Med 24: 699-704.

April 14, 1999
Presenter: Dave Hall, PhD
Paper: Yan L-J, Sohal RS. (1998) Mitochondrial adenine nucleotide translocase is modified oxidatively during aging. PNAS 95: 121896-12901.

Yan L-J, Levine RL, Sohal RS. (1997) Oxidative damage during aging targets mitochondrial aconitase. PNAS 94: 11168-11172.

April 21, 1999
Presenter: Jeanie Kirk
Paper: Carmeliet P et al. (1998) Role of HIF-1a in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis. Nature 394: 485-490.

Aptil 28, 1999
Presenter: Eric Kelley
Paper: Khaselev N, Murphy RC. (1999) Susceptibility of plasmenyl glycerophosphoethanolamine lipids containing arachidonate to oxidative degradation. Free Radic Biol Med 26: 275-284.

May 05, 1999
Presenter: Brett Wagner
Paper: Guerrero A et al. (1999) Effect of thyroid status on lipid composition and peroxidation in the mouse liver. Free Radic Biol Med 26: 73-80.

May 12, 1999
Presenter: Garry R. Buettner, PhD,
No Paper: Free Radicals in Biology and Medicine class notes on "Redox State".

May 19, 1999
Presenter: Larry W. Oberley, PhD & Garry R. Buettner, PhD
Paper: Rae TD et al. (1999) Undetectable intracellular free copper: the requirement of a copper chaperone for superoxide dismutase. Science 284: 805-808.