Spring 2007

12:00-1:00, Wednesdays

Room B180, Med Labs
Contact: garry-buettner@uiowa.edu Tel 319/335-6749

January 17
Presenter: Dr. Garry Buettner
Paper: Jang S, Imlay JA. (2007) Micromolar intracellular hydrogen peroxide disrupts metabolism by damaging iron-sulfur enzymes. J Biol Chem. 282(2):929-937.<Link>

January 24
Presenter: Kjerstin Owens
Paper: Fedotcheva NI, Sokolov AP, Kondrashova MN. (2006) Nonezymatic formation of succinate mitochondria under oxidative stress. FRBM 41:56- 64.<Link>

January 31
Presenter: Disha Dayal
Paper: Hyodo F, Matsumoto K, Matsumoto A, Mitchell JB, Krishna MC (2006). Probing the intracellular redox status of tumors with magnetic resonance imaging and redox-sensitive contrast agents. Cancer Res. 2006 Oct 15;66(20):9921-8.<Link>

February 7
Presenter: Nukhet Aykin-Burns
Paper: Bobko AA, Kirilyuk IA, Grigor'ev IA, Zweier JL, Khramtsov VV. (2007) Reversible reduction of nitroxides to hydroxylamines: Roles for ascorbate and glutathione. Free Radic Biol Med. 42(3):404-412.<Link>

February 14
Presenter: Adam Case
Paper: Wang J-G, Mahmud SA, Thmpson JA, Geng J-G, Key NS, Slungaard A. (2006) The principal eosinophil peroxidase product, HOSCN, is a uniquely potent phagocyte oxidant inducer of endothelial cell tissue factor activity: a potential mechanism for thrombosis in eosinophilic inflammatory states. Blood 107(2):558-565.<Link>

February 21
Presenter: Nukhet Aykin-Burns
Paper: Ogusucu R, Rettori D, Munhoz DC, Soares Netto LE, Augusto O. (2007) Reactions of yeast thioredoxin peroxidases I and II with hydrogen peroxide and peroxynitrite: Rate constants by competitive kinetics. Free Radic Biol Med. 42(3):326-334.<Link>

February 28
Presenter: Dr. Garry Buettner
Paper: It has been 50 years since the introduction of the Free Radical Theory of Aging. To commemorate this milestone, this week in FRJC we will to discuss the very first papers that introduced this idea and then engage in a free wheeling discussion to consider the current status of this theory. It should be fun.
Papers to be discussed are:
COMMONER B, TOWNSEND J, PAKE GE. (1954) Free radicals in biological materials. Nature. 174(4432):689-691.

HARMAN D. (1956) Aging: a theory based on free radical and radiation chemistry. J Gerontol. 11(3):298-300.

HARMAN D. (1957) Prolongation of the normal life span by radiation protection chemicals. J Gerontol. 12(3):257-263

March 7
Presenter: Ann Simons
Paper: Tangpong J, Cole MP, Sultana R, Estus S, Vore M, St Clair W, Ratanachaiyavong S, St Clair DK, Butterfield DA. (2007) Adriamycin- mediated nitration of manganese superoxide dismutase in the central nervous system: insight into the mechanism of chemobrain. 1:
J Neurochem. 100(1):191-201.<Link>

March 14
Presenter: No Journal Club, Spring Break

March 21
Presenter: Dr. Douglas Spitz
Paper: Walker DW, Hajek P, Muffat J, Knoepfle D, Cornelison S, Attardi G, Benzer S. (2006) Hypersensitivity to oxygen and shortened lifespan in a Drosophila mitochondrial complex II mutant. Proc Natl Acad Sci U S A. 103(44):16382-16387.<Link>

March 28
Presenter: Kim Krager
Paper: Dasgupta A, Das S, Kumar Sarkar P. (2007) Thyroid hormone promotes glutathione synthesis in astrocytes by up regulation of glutamate cysteine ligase through differential stimulation of its catalytic and modulator subunit mRNAs. Free Radic Biol Med. 42(5):617-626.<Link>

April 4
Presenter: Chang-Ming Cheng
Paper: Zielonka J, Sarna T, Roberts JE, Wishart JF, Kalyanaraman B. (2006) Pulse radiolysis and steady-state analyses of the reaction between hydroethidine and superoxide and other oxidants. Arch Biochem Biophys. 456(1):39-47.<Link>

April 11
Presenter: Kristy Powers
Paper: Aronoff DM, Oates JA, Boutaud O. (2006) New insights into the mechanism of action of acetaminophen: Its clinical pharmacologic characteristics reflect its inhibition of the two prostaglandin H2 synthases. Clin Pharmacol Ther. 79(1):9-19.<Link>

April 18
Presenter: Melissa Fath
Paper: Vermulst M, Bielas JH, Kujoth GC, Ladiges WC, Rabinovitch PS, Prolla TA, Loeb LA. (2007) Mitochondrial point mutations do not limit the natural lifespan of mice. Nat Genet. 39(4):540-543.<Link>

April 25
Presenter: Peter Scarbrough
Paper: Dinis-Oliveira RJ, Sousa C, Remiao F, Duarte JA, Navarro AS, Bastos ML, Carvalho F. (2007) Full survival of paraquat-exposed rats after treatment with sodium salicylate. Free Radic Biol Med. 42(7):1017-1028.<Link>

May 2
Presenter: Tanja Hadzic
Paper: San Martin A, Foncea R, Laurindo FR, Ebensperer R, Griendling KK, and Leighton F. (2007) Nox1-based NADPH oxidase-derived superoxide is required for VSMC activation by advanced glycation end-products. Free Radic Biol Med. 42:1671-1979. <Link>