Spring 2011

12:00-1:00, Wednesdays

Room B180, Med Labs

Contact: garry-buettner@uiowa.edu Tel 319/335-6749


May 4, 2011
Presenter: Dr. Joshua Madsen
Paper: Bordoli MR, Stiehl DP, Borsig L, Kristiansen G, Hausladen S, Schraml P, Wenger RH, Camenisch G. (2011) Prolyl-4-hydroxylase PHD2- and hypoxia-inducible factor 2-dependent regulation of amphiregulin contributes to breast tumorigenesis. Oncogene. 30(5):548-60. PMID: 20856199

January 19, 2011
Presenter: Webinar Free Radical School Virtual Seminar: ROS/RNS in Ischemia Reperfusion
Speaker: Chris Kevil, Ph.D., LSU Health Sciences Center
Length of session: 45 - 60 minutes

January 26, 2011
Presenter: Jeffrey He
Paper: Zhou R, Yazdi AS, Menu P, Tschopp J. (2010) A role for mitochondria in NLRP3 inflammasome activation. Nature. [Epub ahead of print]

February 2, 2011
Presenter: Canceled due to inclimate weather

February 9, 2011
Presenter: Tony Cyr
Paper: Babaev VR, Whitesell RR, LiL, Linton MF, Fazio S, May JM. (2011) Selective macrophage ascorbate deficiency suppresses early atherosclerosis. Free Radic Biol Med. 50(1):27-36. PMID: 20974251.

February 16, 2011
Presenter: Prabhat Goswami
Paper: Cosentino C, Domenico Grieco D, and Costanzo V. (2011) ATM activates the pentose phosphate pathway promoting anti-oxidant defence and DNA repair. The EMBO Journal, 30:546-555.

February 23, 2011
Presenter: Dr. James Mezhir
Paper: De Luca A, Sanna F, Sallese M, Ruggiero C, Grossi M, Sacchetta P, Rossi C, De Laurenzi V, Di Ilio C, Favaloro B. (2010) Methionine sulfoxide reductase A down-regulation in human breast cancer cells results in a more aggressive phenotype. Proc Natl Acad Sci U S A. 107(43):18628-33. PMID: 20937881 PMCID: PMC2972941

March 2, 2011
presenter: Dr. Garry R. Buettner
Paper: Tiso M, Tejero J, Basu S, Azarov I, Wang X, Simplaceanu V, Frizzell S, Jayaraman T, Geary L, Shapiro C, Ho C, Shiva S, Kim-Shapiro DB, Gladwin MT. (2011) Human neuroglobin functions as a redox regulated nitrite reductase. J Biol Chem. 2011 Feb 4. PMID: 21296891

March 9, 2011
Presenter: Dr. Douglas R. Spitz
Paper: Le A, Cooper CR, Gouw AM, Dinavahi R, Maitra A, Deck LM, Royer RE, Vander Jagt DL, Semenza GL, Dang CV. (2010) Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression. Proc Natl Acad Sci U S A. 107(5):2037-42. PMID: 20133848 PMCID: PMC2836706

March 16, 2011
Presenter: No journal - Spring Break

March 23, 2011
Presenter: Melissa Fath
Paper: Finley LW, Carracedo A, Lee J, Souza A, Egia A, Zhang J, Teruya-Feldstein J, Moreira PI, Cardoso SM, Clish CB, Pandolfi PP, Haigis MC. (2011) SIRT3 Opposes Reprogramming of Cancer Cell Metabolism through HIF1α Destabilization. Cancer Cell. 19(3):416-28.

March 30, 2011
Presenter: Frederick E. Domann
Paper: Iqbal K, Jin SG, Pfeifer GP, Szabó PE. (2011) Reprogramming of the paternal genome upon fertilization involves genome-wide oxidation of 5-methylcytosine. Proc Natl Acad Sci U S A. 108(9):3642-7. PMID: 21321204

April 6, 2011
Presenter: Dr. Lauren Wegman
Paper: Bejarano I, Espino J, Marchena AM, Barriga C, Paredes SD, Rodríguez AB, Pariente JA. Melatonin enhances hydrogen peroxide-induced apoptosis in human promyelocytic leukaemia HL-60 cells. Mol Cell Biochem. 2011 Mar 23. [Epub ahead of print]

April 13, 2011
Presenter: Cam Cushing
Paper: Jiang P, Du W, Wang X, Mancuso A, Gao X, Wu M, Yang X. (2011) p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase. Nat Cell Biol. 13(3):310-6. PMID: 21336310

April 20, 2011
Presenter: Dr. James Jacobus
Paper: Wang SK, Weaver JD, Zhang S, Lei XG. (2011) Knockout of SOD1 promotes conversion of selenocysteine to dehydroalanine in murine hepatic GPX1 protein. Free Radic Biol Med. [Epub ahead of print] PMID: 21420488

April 27, 2011
Presenter: Mitchell Coleman
Paper: Cochemé HM, Quin C, McQuaker SJ, et al. (2011) Measurement of H2O2 within Living Drosophila during Aging Using a Ratiometric Mass Spectrometry Probe Targeted to the Mitochondrial Matrix. Cell Metab. 13(3):340-50. PMID: 21356523