Spring 2015, 11:30-12:30, Mondays, Room B180, Med Labs

Contact: garry-buettner@uiowa.edu Tel 319/335-6749

January 26, 2015
Presenter:  Dr. Garry R. Buettner
Paper:  Nishii W, Kukimoto-Niino M, Terada T, Shirouzu M, Muramatsu T, Kojima M, Kihara H, Yokoyama S. A redox switch shapes the Lon protease exit pore to facultatively regulate proteolysis. Nat Chem Biol. 2015 Jan;11(1):46-51. doi: 10.1038/nchembio.1688. PubMed PMID: 25383757.

February 9, 2015
Presenter:  Cameron Cushing
Paper:  Terpstra M, Tkác I, Rao R, Gruetter R. Quantification of vitamin C in the rat brain in vivo using short echo-time 1H MRS. Magn Reson Med. 2006 May;55(5):979-83. PMID: 16586452. http://onlinelibrary.wiley.com/doi/10.1002/mrm.20854/pdf
additional material from:
Terpstra M, Ugurbil K, Tkac I. Noninvasive quantification of human brain ascorbate concentration using 1H NMR spectroscopy at 7 T. NMR Biomed. 2010 Apr;23(3):227-32. doi: 10.1002/nbm.1423. PMCID: PMC3274383. http://onlinelibrary.wiley.com/doi/10.1002/nbm.1423/pdf

February 23, 2015
Presenter:  Jyungmean Son
Paper:  Lee Y, Dominy JE, Choi YJ, Jurczak M, Tolliday N, Camporez JP, Chim H, Lim JH, Ruan HB, Yang X, Vazquez F, Sicinski P, Shulman GI, Puigserver P. Cyclin D1-Cdk4 controls glucose metabolism independently of cell cycle progression. Nature. 2014 Jun 26;510(7506):547-51. doi: 10.1038/nature13267. Epub 2014 May 25. PMID: 24870244, PMCID: PMC4076706.
[DOI Link, http://dx.doi.org/doi: 10.1038/nature13267].

March 9, 2015
Presenter:  Shane Solst
Paper: Szczesny B, Módis K, Yanagi K, Coletta C, Le Trionnaire S, Perry A, Wood ME, Whiteman M, Szabo C. AP39, a novel mitochondria-targeted hydrogen sulfide donor, stimulates cellular bioenergetics, exerts cytoprotective effects and protects against the loss of mitochondrial DNA integrity in oxidatively stressed endothelial cells in vitro. Nitric Oxide. 2014 Sep 15;41:120-30. doi: 10.1016/j.niox.2014.04.008. PMID: 24755204; PMCID: PMC4225488.

March 23, 2015
Presenter:  Joshua Schoenfeld
Paper: Sobotta MC, Liou W, Stöcker S, Talwar D, Oehler M, Ruppert T, Scharf AN, Dick TP. Peroxiredoxin-2 and  STAT3 form a redox relay for H2O2 signaling. Nat Chem Biol. 2015 Jan;11(1):64-70. doi: 10.1038/nchembio.1695. PMID: 25402766.
Commentary Paper:  Winterbourn CC and Hampton MB. Redox biology: signaling via a peroxiredoxin sensor. Nat Chem Biol. 2015 Jan;11(1):5-6. doi: 10.1038/nchembio.1722.  PMID: 25517384.

April 6, 2015
Presenter:  John Lafin
Paper: Brault C, Lévy P, Duponchel S, Michelet M, Sallé A, Pécheur EI, Plissonnier ML, Parent R, Véricel E, Ivanov AV, Demir M, Steffen HM, Odenthal M, Zoulim F, Bartosch B. Glutathione peroxidase 4 is reversibly induced by HCV to control lipid peroxidation and to increase virion infectivity. Gut. 2014 Dec 16.
PMID: 25516417.  Doi: 10.1136/gutjnl-2014-307904.

April 20, 2015
Presenter:  Adrienne Klinger
Paper: Özdemir BC, Pentcheva-Hoang T, Carstens JL, Zheng X, Wu CC, Simpson TR, Laklai H, Sugimoto H, Kahlert C, Novitskiy SV, De Jesus-Acosta A, Sharma P, Heidari P, Mahmood U, Chin L, Moses HL, Weaver VM, Maitra A, Allison JP, LeBleu VS, Kalluri R. Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival. Cancer Cell. 2014 Jun 16. PMID: 24856586. Doi: 10.1016/j.ccr.2014.04.005

May 4, 2015
Presenter:  Paige Kluz
Paper: Saragih H, Zilian E, Jaimes Y, Paine A, Figueiredo C, Eiz-Vesper B.. Immenschuh S. PECAM-1-dependent heme oxygenase-1 regulation via an Nrf2-mediated pathway in endothelial cells. Thromb Haemost, 2014;111(6):1077-1088. PMID: 24500083. doi: 10.1160/TH13-11-0923