Free Radical Journal Club, The University of Iowa
Spring 2021, 11:30-12:30, Mondays, Room B180, Med Labs
Contact: Tel 319/335-8014
Zoom Link:
Meeting ID: 968 9142 8453

February 1, 2021
Presenter:  Dr. Rick Domann
Paper: Byrne DP, Shrestha S, Galler M, Cao M, Daly LA, Campbell AE, Eyers CE, Veal EA, Kannan N, Eyers PA. Aurora A regulation by reversible cysteine oxidation reveals evolutionarily conserved redox control of Ser/Thr protein kinase activity. Sci Signal. 2020 Jul 7;13(639):eaax2713. PMID: 32636306.
doi: 10.1126/scisignal.aax2713

February 15, 2021
Presenter:  Emily Steinbach
Paper: Cheng P, Liu H, Li Y, Pi P, Jiang Y, Zang S, Li X, Fu A, Ren X, Xu J, Holmgren A, Lu J. Inhibition of thioredoxin reductase 1 correlates with platinum-based chemotherapeutic induced tissue injury. Biochem Pharmacol. 2020 May;175:113873. Epub 2020 Feb 21. PMID: 32092292.
doi: 10.1016/j.bcp.2020.113873.

March 1, 2021
Presenter:  Dr, GarryBuettner
Paper:  Pardue S, Kolluru GK, Shen X, Lewis SE, Saffle CB, Kelley EE, Kevil CG. (2020 Hydrogen sulfide stimulates xanthine oxidoreductase conversion to nitrite reductase and formation of NO. Redox Biol. 34:101447.   PMID: 32035920  
Open Access at

March 15, 2021
Presenter: Dr. Garry Buettner
Paper: Lundberg J, Weitzberg E. (2021) COMPOSITIONS OF NITRATES AND METHODS OF USE THEREOF.  Feb 11, 2021. US Patent Application: US 2021/0038639 A1,  for Heartbeet Ltd.

March 29, 2021
Presenter: Dr. Douglas Spitz
Paper:  Wang Z, Sun R, Wang G, Chen Z, Li Y, Zhao Y, Liu D, Zhao H, Zhang F, Yao J, Tian X. SIRT3-mediated deacetylation of PRDX3 alleviates mitochondrial oxidative damage and apoptosis induced by intestinal ischemia/reperfusion injury. Redox Biol. 2020 Jan;28:101343. Epub 2019 Oct 12. PMID: 31655428; PMCID: PMC6820261.
doi: 10.1016/j.redox.2019.101343

April 12, 2021
Presenter:  Mike Liman

April 26, 2021
Presenter:  Dr. Rick Domann
Paper:  Cordes T, Metallo CM. Itaconate Alters Succinate and Coenzyme A Metabolism via Inhibition of Mitochondrial Complex II and Methylmalonyl-CoA Mutase. Metabolites. 2021 Feb 18;11(2):117. PMID: 33670656; PMCID: PMC7922098.
doi: 10.3390/metabo11020117