Spring 2022
FREE RADICAL JOURNAL CLUB (FRRB:6006)
Spring 2022 Director: Garry Buettner
The University of Iowa,
11:30 - 12:30, Every Other Monday
Virtual
Zoom Link: https://uiowa.zoom.us/j/96375130138
Meeting ID: 963 7513 0138
Presentations for Spring 2022:
January 31, 2022
Presenter: Dr. Garry Buettner
Paper: Guarino VA, Oldham WM, Loscalzo J, Zhang YY. (2019) Reaction rate of pyruvate and hydrogen peroxide: assessing antioxidant capacity of pyruvate under biological conditions. Sci Rep. 9(1):19568. PMID: 31862934; PMCID: PMC6925109.
http://doi.org/10.1038/s41598-019-55951-9
February 14, 2022
Presenter: Yuna Bayanbold
Paper: Yambire KF, Rostosky C, Watanabe T, Pacheu-Grau D, Torres-Odio S, Sanchez-Guerrero A, Senderovich O, Meyron-Holtz EG, Milosevic I, Frahm J, West AP, Raimundo N. Impaired lysosomal acidification triggers iron deficiency and inflammation in vivo. Elife. 2019 Dec 3;8:e51031. PMID: 31793879; PMCID: PMC6917501.
doi: 10.7554/eLife.51031
Presenter: Maddie Hines
Paper: Chiang S, Braidy N, Maleki S, Lal S, Richardson DR, Huang ML. Mechanisms of impaired mitochondrial homeostasis and NAD+ metabolism in a model of mitochondrial heart disease exhibiting redox active iron accumulation. Redox Biol. 2021 Oct;46:102038. Epub 2021 Jun 10. PMID: 34416478; PMCID: PMC8379503.
doi: 10.1016/j.redox.2021.102038
March 14, 2022, SPRING BREAK
No journal club
March 28, 2022, a shorter Journal Club
Presenter: Garry Buettner
Paper: Fass D, Semenov SN. (2021) Previously unknown type of protein crosslink discovered. Nature. 593(7859):343-344. http://doi.org/10.1038/d41586-021-01135-3 PMID: 33953388
Paper: Wensien M, von Pappenheim FR, Funk LM, Kloskowski P, Curth U, Diederichsen U, Uranga J, Ye J, Fang P, Pan KT, Urlaub H, Mata RA, Sautner V, Tittmann K. (2021) A lysine-cysteine redox switch with an NOS bridge regulates enzyme function. Nature. 593(7859):460-464. http://doi.org/10.1038/s41586-021-03513-3 PMID: 33953398
April 11, 2022
Presenter: Doug Spitz
Paper: Romani P, Nirchio N, Arboit M, Barbieri V, Tosi A, Michielin F, Shibuya S, Benoist T, Wu D, Hindmarch CCT, Giomo M, Urciuolo A, Giamogante F, Roveri A, Chakravarty P, Montagner M, Calì T, Elvassore N, Archer SL, De Coppi P, Rosato A, Martello G, Dupont S. Mitochondrial fission links ECM mechanotransduction to metabolic redox homeostasis and metastatic chemotherapy resistance. Nat Cell Biol. 2022 Feb;24(2):168-180. Epub 2022 Feb 14. PMID: 35165418.
doi: 10.1038/s41556-022-00843-w
April 25, 2022
Presenter: Dr. Rick Domann
doi: 10.1073/pnas.2105053118