Free Radical Journal Club (FRRB:6006)
Spring 2024 (Director: Dr. Corinne Griguer)
11:30 AM - 12:30 PM, Every Other Monday, Room B180 ML

Presentations for Spring 2024:

January 29, 2024

Presenter: Douglas Spitz
Title: Ilter D, Drapela S, Schild T, Ward NP, Adhikari E, Low V, Asara J, Oskarsson T, Lau EK, DeNicola GM, McReynolds MR, Gomes AP. NADK-mediated de novo NADP(H) synthesis is a metabolic adaptation essential for breast cancer metastasis. Redox Biol. 2023 May;61:102627. doi: 10.1016/j.redox.2023.102627. Epub 2023 Feb 9. PMID: 36841051; PMCID: PMC9982641.


February 12, 2024

Presenter: Sunny Huang
Title: Ghrayeb A, Finney AC, Agranovich B, Peled D, Anand SK, McKinney MP, Sarji M, Yang D, Weissman N, Drucker S, Fernandes SI, Fernández-García J, Mahan K, Abassi Z, Tan L, Lorenzi PL, Traylor J, Zhang J, Abramovich I, Chen YE, Rom O, Mor I, Gottlieb E. Serine synthesis via reversed SHMT2 activity drives glycine depletion and acetaminophen hepatotoxicity in MASLD. Cell Metab. 2024 Jan 2;36(1):116-129.e7. doi: 10.1016/j.cmet.2023.12.013. PMID: 38171331; PMCID: PMC10777734.


February 26, 2024

Presenter: Kyle Current
Title: Li S, Yokota T, Wang P, Ten Hoeve J, Ma F, Le TM, Abt ER, Zhou Y, Wu R, Nanthavongdouangsy M, Rodriguez A, Wang Y, Lin YJ, Muranaka H, Sharpley M, Braddock DT, MacRae VE, Banerjee U, Chiou PY, Seldin M, Huang D, Teitell M, Gertsman I, Jung M, Bensinger SJ, Damoiseaux R, Faull K, Pellegrini M, Lusis AJ, Graeber TG, Radu CG, Deb A. Cardiomyocytes disrupt pyrimidine biosynthesis in nonmyocytes to regulate heart repair. J Clin Invest. 2022 Jan 18;132(2):e149711. doi: 10.1172/JCI149711. PMID: 34813507; PMCID: PMC8759793.


March 11, 2024

No Journal Club; Spring Break


March 25, 2024
Presenter: Amira Zaher
Title: Rodríguez-Nuevo A, Torres-Sanchez A, Duran JM, De Guirior C, Martínez-Zamora MA, Böke E. Oocytes maintain ROS-free mitochondrial metabolism by suppressing complex I. Nature. 2022 Jul;607(7920):756-761. doi: 10.1038/s41586-022-04979-5. Epub 2022 Jul 20. PMID: 35859172; PMCID: PMC9329100.

April 8, 2024
Presenter: Mortezaali Razzaghi
Title: Ahmed W, Lingner J. PRDX1 Counteracts Catastrophic Telomeric Cleavage Events That Are Triggered by DNA Repair Activities Post Oxidative Damage. Cell Rep. 2020 Nov 3;33(5):108347. doi: 10.1016/j.celrep.2020.108347. PMID: 33147465.

April 22, 2024
Presenter: Akshaya Warrier
Title: Jiang Y, Song L, Lin Y, Nowialis P, Gao Q, Li T, Li B, Mao X, Song Q, Xing C, Zheng G, Huang S, Jin L. ROS-mediated SRMS activation confers platinum resistance in ovarian cancer. Oncogene. 2023 May;42(20):1672-1684. doi: 10.1038/s41388-023-02679-6. Epub 2023 Apr 5. PMID: 37020040; PMCID: PMC10231978.