CURRENT TOPICS IN FREE RADICAL BIOLOGY AND MEDICINE

FRRB:6006

SCHEDULE OF PRESENTATIONS

Spring 2026

Director: Dr. Douglas Spitz

11:30 AM - 12.30 PM EVERY OTHER MONDAY IN 1180 ML

Presentations for Spring 2026

January 26, 2026

Presenter: Douglas Spitz

Paper: Greenwood HE, Barber AR, Edwards RS, Tyrrell WE, George ME, Dos Santos SN, Baark F, Tanc M, Khalil E, Falzone A, Ward NP, DeBlasi JM, Torrente L, Soni PN, Pearce DR, Firth G, Smith LM, Vilhelmsson Timmermand O, Huebner A, Swanton C, Hynds RE, DeNicola GM, Witney TH. Imaging NRF2 activation in non-small cell lung cancer with positron emission tomography. Nat Commun. 2024 Dec 17;15(1):10484. doi: 10.1038/s41467-024-54852-4. PMID: 39690148; PMCID: PMC11652680.

February 9, 2026

Presenter: Prabhat Goswami

Paper: Patel N, Kalen AL, Isakov L, Neuschwander G, Asha W, Son J, Schibler J, Goswami PC, Sarsour EH. G0/G1 Switch 2 Regulates Radiation Sensitivity of Human Head and Neck Cancer through a G1-lipid Checkpoint. Radiat Res. 2026 Jan 8;205(1):1-15. doi: 10.1667/RADE-24-00143.1. PMID: 41285160.

February 23, 2026

Presenter: John McFadden

Paper: Kanavos I, Nakahata DH, Barrett MS, Dos Santos AF, Zubiria-Ulacia M, Pieslinger GE, da Silva Teixeira AB, Medeiros I, Rocha CRR, Eberle J, Lobinski R, Matxain JM, Hall MD, Friedmann Angeli JP, Arnér ESJ, Ronga L, de Paiva REF. What lies beyond thioredoxin reductase? Cyclometallated gold compounds reveal Sec selectivity in glutathione peroxidases. Free Radic Biol Med. 2026 Feb 5;247:139-156. doi: 10.1016/j.freeradbiomed.2026.02.007. Epub ahead of print. PMID: 41654145.

March 9, 2026

Presenter: Roman Mogal

Paper: Xiao Y, Jin L, Deng C, Guan Y, Kalogera E, Ray U, Thirusangu P, Staub J, Sarkar Bhattacharya S, Xu H, Fang X, Shridhar V. Inhibition of PFKFB3 induces cell death and synergistically enhances chemosensitivity in endometrial cancer. Oncogene. 2021 Feb;40(8):1409-1424. doi: 10.1038/s41388-020-01621-4. Epub 2021 Jan 8. PMID: 33420377; PMCID: PMC7906909.

March 23, 2026

Presenter: Joan Whittier

Paper: Qian X, Wang Y, Kuang P, Li B, Jiang K, Wang A, Xiong K, Hong W, Yu B, Qin G, Yao X, Ye X, Luo C, Shu C, Chen D, Zheng W, Chai X, Sun Y, Li Z, Li Y. Ionizing radiation promotes lung injury by inducing ferroptosis-driven senescence in epithelial cells via NCOA4-mediated ferritinophagy. Redox Biol. 2026 Feb 18;91:104091. doi: 10.1016/j.redox.2026.104091. Epub ahead of print. PMID: 41722510; PMCID: PMC12945525.

April 6, 2026

Presenter: Ziyu Wang

Paper: Wu Y, Chen D, Wang X, Song M, Wu J, Wu S, Liao K. Dihydroartemisinin targets GPX4 to induce autophagy-dependent ferroptosis and reduce radioresistance in triple-negative breast cancer. Free Radic Biol Med. 2026 Mar 16;246:35-50. doi: 10.1016/j.freeradbiomed.2025.12.060. Epub 2026 Jan 9. PMID: 41520847.

April 20, 2026

Presenter: Krishna Awasthi

Paper: Lang X, Green MD, Wang W, Yu J, Choi JE, Jiang L, Liao P, Zhou J, Zhang Q, Dow A, Saripalli AL, Kryczek I, Wei S, Szeliga W, Vatan L, Stone EM, Georgiou G, Cieslik M, Wahl DR, Morgan MA, Chinnaiyan AM, Lawrence TS, Zou W. Radiotherapy and Immunotherapy Promote Tumoral Lipid Oxidation and Ferroptosis via Synergistic Repression of SLC7A11. Cancer Discov. 2019 Dec;9(12):1673-1685. doi: 10.1158/2159-8290.CD-19-0338. Epub 2019 Sep 25. PMID: 31554642; PMCID: PMC6891128.

May 4, 2026

Presenter: Nafis Irfan

Paper: Patel SA, Nilsson MB, Yang Y, Le X, Tran HT, Elamin YY, Yu X, Zhang F, Poteete A, Ren X, Shen L, Wang J, Moghaddam SJ, Cascone T, Curran M, Gibbons DL, Heymach JV. IL6 Mediates Suppression of T- and NK-cell Function in EMT-associated TKI-resistant EGFR-mutant NSCLC. Clin Cancer Res. 2023 Apr 3;29(7):1292-1304. doi: 10.1158/1078-0432.CCR-22-3379. PMID: 36595561; PMCID: PMC10290888.