CURRENT TOPICS IN RADIATION AND CANCER BIOLOGY (FRRB:6008)
SCHEDULE OF PRESENTATIONS
Fall 2024 (Director: Dr. Douglas Spitz)
11:30 AM - 12.30 PM EVERY OTHER MONDAY IN ROOM B180 Med Labs

Presentations for Fall 2024

August 26, 2024

Presenter: Douglas Spitz

Paper: Hsieh MS, Ling HH, Setiawan SA, Hardianti MS, Fong IH, Yeh CT, Chen JH. Therapeutic targeting of thioredoxin reductase 1 causes ferroptosis while potentiating anti-PD-1 efficacy in head and neck cancer. Chem Biol Interact. 2024 May 25;395:111004. doi: 10.1016/j.cbi.2024.111004. Epub 2024 Apr 16. PMID: 38636790.

September 9, 2024

Presenter: Amanda Pope

Paper: Chen L, Zhang Z, Hoshino A, Zheng HD, Morley M, Arany Z, Rabinowitz JD. NADPH production by the oxidative pentose-phosphate pathway supports folate metabolism. Nat Metab. 2019 Mar;1:404-415. Epub 2019 Mar 11. PMID: 31058257; PMCID: PMC6489125.

September 23, 2024

Presenter: Melissa Fath
Paper: Hajihassani O, Zarei M, Roichman A, Loftus A, Boutros CS, Hue J, Naji P, Boyer J, Tahan S, Gallagher P, Beegan W, Choi J, Lei S, Kim C, Rathore M, Nakazzi F, Shah I, Lebo K, Cheng H, Mudigonda A, Alibeckoff S, Ji K, Graor H, Miyagi M, Vaziri-Gohar A, Brunengraber H, Wang R, Lund PJ, Rothermel LD, Rabinowitz JD, Winter JM. A Ketogenic Diet Sensitizes Pancreatic Cancer to Inhibition of Glutamine Metabolism. bioRxiv [Preprint]. 2024 Jul 23:2024.07.19.604377. doi: 10.1101/2024.07.19.604377. PMID: 39211182; PMCID: PMC11361133.

October 7, 2024

Presenter: Prabhat Goswami

Paper: Zabransky DJ, Chhabra Y, Fane ME, Kartalia E, Leatherman JM, Hüser L, Zimmerman JW, Delitto D, Han S, Armstrong TD, Charmsaz S, Guinn S, Pramod S, Thompson ED, Hughes SJ, O'Connell J, Egan JM, Jaffee EM, Weeraratna AT. Fibroblasts in the Aged Pancreas Drive Pancreatic Cancer Progression. Cancer Res. 2024 Apr 15;84(8):1221-1236. doi: 10.1158/0008-5472.CAN-24-0086. PMID: 38330147.

October 21, 2024

Presenter: Kelly Hubert

Paper: Jiang Y, Wang Y, Chen G, Sun F, Wu Q, Huang Q, Zeng D, Qiu W, Wang J, Yao Z, Liang B, Li S, Wu J, Huang N, Wang Y, Chen J, Zhai X, Huang L, Xu B, Yamamoto M, Tsukamoto T, Nomura S, Liao W, Shi M. Nicotinamide metabolism face-off between macrophages and fibroblasts manipulates the microenvironment in gastric cancer. Cell Metab. 2024 Aug 6;36(8):1806-1822.e11. doi: 10.1016/j.cmet.2024.05.013. Epub 2024 Jun 18. PMID: 38897198.

November 4, 2024

Presenter: Canceled

November 18, 2024

Presenter: Nafis Irfan

Paper: Ford K, Hanley CJ, Mellone M, Szyndralewiez C, Heitz F, Wiesel P, Wood O, Machado M, Lopez MA, Ganesan AP, Wang C, Chakravarthy A, Fenton TR, King EV, Vijayanand P, Ottensmeier CH, Al-Shamkhani A, Savelyeva N, Thomas GJ. NOX4 Inhibition Potentiates Immunotherapy by Overcoming Cancer-Associated Fibroblast-Mediated CD8 T-cell Exclusion from Tumors. Cancer Res. 2020 May 1;80(9):1846-1860. doi: 10.1158/0008-5472.CAN-19-3158. Epub 2020 Mar 2. PMID: 32122909; PMCID: PMC7611230.

December 2, 2024

Presenter: Ziyu Wang

Paper: Freire Boullosa L, Van Loenhout J, Flieswasser T, Hermans C, Merlin C, Lau HW, Marcq E, Verschuuren M, De Vos WH, Lardon F, Smits ELJ, Deben C. Auranofin Synergizes with the PARP Inhibitor Olaparib to Induce ROS-Mediated Cell Death in Mutant p53 Cancers. Antioxidants (Basel). 2023 Mar 8;12(3):667. doi: 10.3390/antiox12030667. PMID: 36978917; PMCID: PMC10045521.