The University of Iowa

Fall 1997

11:30-12:30, Mondays

Room B180, Med Labs

Contact: Tel 319-335-8025

August 25, 1997
Organizational Meeting

September 08, 1997
Presenter: Mike Robbins
Paper: "Tirapazamine-induced Cytotoxicity and DNA Damage in Transplanted Tumors: Relationship to Tumor Hypoxia" by Siim et al. from Cancer Res. 57:2922-2928 (1997)

September 15, 1997
Presenter: Yuanhui Huang
Paper: "Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner" by Fiscella et al. PNAS 94:6048-6053 (1997)

September 22, 1997
Presenter: Weiling Zhao
Paper: "Regulation of DNA damage-induced apoptosis by the c-Ab1 tyrosine kinase" by Zhi-Min Yuan et al. PNAS 94:1437-1440 (1997)

September 29, 1997
Presenter: Nick Khoo
Paper: "p73 is a human p53-related protein that can induce apoptosis" by Christine A. Jost et al. Nature 189:191-194 (1997)

October 06, 1997
Presenter: Meredith Preuss
Paper: "Suppression of Metastasis in Human Breast Carcinoma MDA- MB-435 Cells after Transfection with the Metastasis Suppressor Gene, KiSS-1" by J.-H. Lee and D.R. Welch, Cancer Research 57:2384-2387 (June 15, 1997)

October 13, 1997
Presenter: Dr. Rick Domann
Paper: "Human DNA-(Cytosine-5) Methyltransferase-PCNA Complex as a Target for p21(WAF1) by L.S.-H. Chuang et al. in Science, Vol. 277, September 26, 1997, pp. 1996-2000

October 20, 1997
Presenter: Dr. Bill Osborne
Paper: "Stem Cell Factor Has Contrasting Effects in Combination with 5- Fluorouracil or Total-Body Irradiation on Frequencies of Different Hemopoietic Cell Subsets and Engraftment of Transplanted Bone Marrow," J.D. Down et al., Radiat. Res. 147:680-685, 1997.

October 27, 1997
Presenter: Yuanhui Huang
Paper: "In vivo evidence for binding of p53 to consensus binding sites in the p21 and GADD45 genes in response to ionizing radiation," P.L. Chin et al., Oncogene 15:88-97, 1997.

November 03, 1997
Presenter: Meredith Preuss
Paper: "Mechanism of Inhibition of Proliferating Cell Nuclear Antigen- Dependent DNA Synthesis by the Cyclin-Dependent Kinase Inhibitor p21," by V.N. Podust et al.., Biochemistry, 34:8869-8875, 1995.

November 10, 1997
Presenter: Geoff Girnun
Paper: "Terminal differentiation of human liposarcoma cells induced by ligands for peroxisome proliferator-activated receptor g and the retinoid X receptor," by P. Tontonoz et al., Proc. Natl. Acad. Sci. USA, 94:237- 241, 1997.

November 17, 1997
Presenter: Weiling Zhao
Paper: "atm and p53 cooperate in apoptosis and suppression of tumorigenesis, but not in resistance to acute radiation toxicity," by C.H. Westphal et al., Nature Genetics, 16:397-401, 1997.

November 24, 1997
Presenter: Nick Khoo
Paper: "Transfection of p53-knockout mouse fibroblasts with wild-type p53 increases the thermosensitivity and stimulates apoptosis induced by heat shock," by Matsumoto et al., Int. J. Radiation Oncology Biol. Phys., 38:1089-1095, 1997.