CURRENT TOPICS IN RADIATION AND CANCER BIOLOGY (77:548)

The University of Iowa

Fall 2006

11:30-12:30, Mondays

Room B180, Med Labs

Contact: apollina-goel@uiowa.edu Tel 319-384-4754

August 21, 2006
Presenter: Dr. Prabhat Goswami
Paper: Wang C, Li Z, Lu Y, Du R, Katiyar S, et al. (2006) Cyclin D1 repression of nuclear respiratory factor 1 integrates nuclear DNA synthesis and mitochondrial function. Proc Natl Acad Sci USA. 103(31):11567-11572.[DOI Article]

August 28, 2006
Presenter: Dr. Douglas Spitz
Paper: Das GC, Bacsi A, Shrivastav M, Hazra TK, Boldogh I. (2006) Enhanced gamma-glutamylcysteine synthetase activity decreases drug-induced oxidative stress levels and cytotoxicity. Mol Carcinog. 45(9):635-647.[DOI Article]

September 4, 2006
Presenter: Labor Day, No Journal Club

September 11, 2006
Presenter: Disha Dayal
Paper: Shibayama-Imazu T, Sonoda I, Sakairi S, Aiuchi T, Ann WW, Nakajo S, Itabe H, Nakaya K. (2006) Production of superoxide and dissipation of mitochondrial transmembrane potential by vitamin K(2) trigger apoptosis in human ovarian cancer TYK-nu cells. Apoptosis 11(9):1535-1543.[DOI Article]

September 18, 2006
Presenter: Mike Hitchler
Paper: Wozniak RJ, Klimecki WT, Lau SS, Feinstein Y, Futscher BW. (2006) 5-Aza-2'-deoxycytidine-mediated reductions in G9A histone methyltransferase and histone H3 K9 di-methylation levels are linked to tumor suppressor gene reactivation. Oncogene [Epub ahead of print] [DOI Article]

September 25, 2006
Presenter: Kristy Powers
Paper: Dhar SK, Xu Y, Chen Y, St Clair DK. (2006) Specificity protein 1-dependent p53-mediated suppression of human manganese superoxide dismutase gene expression. J Biol Chem. 281(31):21698-21709.[DOI Article]

October 2, 2006
Presenter: Kjerstin Owens
Paper: Ambrosone CB, Ahn J, Singh KK, Rezaishiraz H, Furberg H, Sweeney C, Coles B, Trovato A. (2005) Polymorphisms in genes related to oxidative stress (MPO, MnSOD, CAT) and survival after treatment for breast cancer. Cancer Res. 65(3):1105-1111.[DOI Article]

October 9, 2006
Presenter: Dr. Mike Knudson
Paper: Trachootham D, Zhou Y, Zhang H, Demizu Y, Chen Z, Pelicano H, Chiao PJ, Achanta G, Arlinghaus RB, Liu J, Huang P. (2006) Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethyl isothiocyanate. Cancer Cell 10(3):241-252.[DOI Article]

October 16, 2006
Presenter: Zhen Gao
Russo AJ, Magro PG, Hu Z, Li WW, Peters R, Mandola J, Banerjee D, Bertino JR. (2006) E2F-1 overexpression in U2OS cells increases cyclin B1 levels and cdc2 kinase activity and sensitizes cells to antimitotic agents. Cancer Res. 66(14):7253-7260.[DOI Article]

October 23, 2006
Presenter: Canceled due to construction in conference room.

October 30, 2006
Presenter: Amanda Kalen
Paper: Robinson HM, Jones R, Walker M, Zachos G, Brown R, Cassidy J, Gillespie DA. (2006) Chk1-dependent slowing of S-phase progression protects DT40 B-lymphoma cells against killing by the nucleoside analogue 5-fluorouracil. Oncogene 25(39):5359-5369.[DOI Article]

November 6, 2006
Presenter: Venkat
Paper: Dote H, Burgan WE, Camphausen K, Tofilon PJ. (2006) Inhibition of hsp90 compromises the DNA damage response to radiation. Cancer Res. 66(18):9211-9220.[DOI Article]

November 13, 2006
Presenter: Kim Krager
Paper: Sieger S, Jiang S, Kleinschmidt J, Eskerski H, Schonsiegel F, Altmann A, Mier W, Haberkorn U. (2004) Tumor-specific gene expression using regulatory elements of the glucose transporter isoform 1 gene. Cancer Gene Ther. 11(1):41-51.[DOI Article]

November 20, 2006
Presenter: Thanksgiving week, no journal club

November 27, 2006
Presenter: Suwimol
Paper: Wang X, Wang F, Taniguchi K, Seelan RS, Wang L, Zarfas KE, McDonnell SK, Qian C, Pan K, Lu Y, Shridhar V, Couch FJ, Tindall DJ, Beebe-Dimmer JL, Cooney KA, Isaacs WB, Jacobsen SJ, Schaid DJ, Thibodeau SN, Liu W. (2006) Truncating Variants in p53AIP1 Disrupting DNA Damage-Induced Apoptosis Are Associated with Prostate Cancer Risk. Cancer Res. 66(21):10302-10307.[DOI Article]

December 4, 2005
Presenter: Ann Simons
Paper: Witte AB, Anestal K, Jerremalm E, Ehrsson H, Arner ES. (2005) Inhibition of thioredoxin reductase but not of glutathione reductase by the major classes of alkylating and platinum-containing anticancer compounds. Free Radic Biol Med. 39(5):696-703.[DOI Article]