The University of Iowa

Fall 2007

11:30-12:30, Mondays

Room B180, Med Labs

Contact: Tel 319-384-4754
August 27, 2007
Presenter: Dr. Douglas Spitz
Paper: Chen EI, Hewel J, Krueger JS, Tiraby C, Weber MR, Kralli A, Becker K, Yates JR, Felding-Habermann B. (2007) Adaptation of energy metabolism in breast cancer brain metastases. Cancer Res. 67(4):1472-1486. [DOI Article]

September 3, 2007
Presenter: Labor Day, No Journal Club

September 10, 2007
Presenter: Kjerstin Owens
Paper: Pelicano H, Xu RH, Du M, Feng L, Sasaki R, Carew JS, Hu Y, Ramdas L, Hu L, Keating MJ, Zhang W, Plunkett W, Huang P. (2006) Mitochondrial respiration defects in cancer cells cause activation of Akt survival pathway through a redox-mediated mechanism. J Cell Biol. 175(6):913-923. [DOI Article]

September 17, 2007
Presenter: Dr. Prabhat Goswami
Paper: Markovic J, Borrás C, Ortega A, Sastre J, Viña J, Pallardó FV. (2007) Glutathione is recruited into the nucleus in early phases of cell proliferation. J Biol Chem. 282(28):20416-20424. [DOI Article]

September 24, 2007
Presenter: Yueming Zhu
Paper: Macaluso M, Montanari M, Noto PB, Gregorio V, Bronner C, Giordano A. (2007) Epigenetic Modulation of Estrogen Receptor-{alpha} by pRb Family Proteins: A Novel Mechanism in Breast Cancer. Cancer Res. 67(16):7731-7737. [DOI Article]

October 1, 2007
Presenter: Dr. Nukhet Aykin-Burns
Paper: Wu KD, Cho YS, Katz J, Ponomarev V, Chen-Kiang S, Danishefsky SJ, Moore MA. (2005) Investigation of antitumor effects of synthetic epothilone analogs in human myeloma models in vitro and in vivo. Proc Natl Acad Sci U S A. 102(30):10640-10645. [DOI Article]

October 8, 2007
Presenter: Adam Case
Paper: Sun Y, St Clair DK, Fang F, Warren GW, Rangnekar VM, Crooks PA, St Clair WH. (2007) The radiosensitization effect of parthenolide in prostate cancer cells is mediated by nuclear factor-{kappa}B inhibition and enhanced by the presence of PTEN. Mol Cancer Ther. 6(9):2477-2486. [DOI Article]

October 15, 2007
Presenter: Disha Dayal
Paper: St-Pierre J, Drori S, Uldry M, Silvaggi JM, Rhee J, Jäger S, Handschin C, Zheng K, Lin J, Yang W, Simon DK, Bachoo R, Spiegelman BM. (2006) Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators. Cell. 127(2):397-408. [DOI Article]

October 22, 2007
Presenter: Venkat Venkatesha
Paper: Hurd TR, Prime TA, Harbour ME, Lilley KS, Murphy MP. (2007) Detection of reactive oxygen species-sensitive thiol proteins by redox difference gel electrophoresis: implications for mitochondrial redox signaling. J Biol Chem. 282(30):22040-22051. [DOI Article]

October 29, 2007
Presenter: Leena Chauhduri
Paper: Zhang L, Lee KC, Bhojani MS, Khan AP, Shilman A, Holland EC, Ross BD, Rehemtulla A. (2007) Molecular imaging of Akt kinase activity. Nat Med. 13(9):1114-1119. [DOI Article]

November 5, 2007
Presenter: Jennifer Gass
Paper: Singh SV, Choi S, Zeng Y, Hahm ER, Xiao D (2007) Guggulsterone-induced apoptosis in human prostate cancer cells is caused by reactive oxygen intermediate dependent activation of c-Jun NH2-terminal kinase. Cancer Res. 67(15):7439-7449. [DOI Article]

November 12, 2007
Presenter: Peter Scarbrough
Paper: Zhang Y and Shen X. (2007) Heat shock protein 27 protects L929 cells from cisplatin-induced apoptosis by enhancing Akt activation and abating suppression of thioredoxin reductase activity. Clin Cancer Res. 13(10):2855-2864. [DOI Article]

November 19, 2007
Presenter: Thanksgiving week, no journal club

November 26, 2007
Presenter: Dr. Josh Madsen
Paper: Tsuchiya N, Ochiai M, Nakashima K, Ubagai T, Sugimura T, Nakagama H. (2007) SND1, a component of RNA-induced silencing complex, is up-regulated in human colon cancers and implicated in early stage colon carcinogenesis. Cancer Res. 67(19):9568-9576. [DOI Article]

December 3, 2007
Presenter: Senthilkumar PK
Paper: Lauber SN, Gooderham NJ. (2007) The cooked meat derived genotoxic carcinogen 2-amino-3-methylimidazo[4,5-b]pyridine has potent hormone-like activity: mechanistic support for a role in breast cancer. Cancer Res. 67(19):9597 [DOI Article]

December 10, 2007
Presenter: Dr. Melissa Fath
Paper: Dearling JL, Qureshi U, Begent RH, Pedley RB. (2007) Combining radioimmunotherapy with antihypoxia therapy 2-deoxy-D-glucose results in reduction of therapeutic efficacy. Clin Cancer Res. 13(6):1903-1910. [DOI Article]