The University of Iowa

Fall 2008

11:30-12:30, Mondays

Room B180, Med Labs

Contact: Tel 319-384-4754
September 1, 2008
Presenter: Labor Day, No Journal Club

September 8, 2008
Presenter: Josh Madsen
Paper: Ishikawa K, Takenaga K, Akimoto M, Koshikawa N, Yamaguchi A, Imanishi H, Nakada K, Honma Y, Hayashi JI. (2008) ROS-Generating Mitochondrial DNA Mutations Can Regulate Tumor Cell Metastasis. Science 320(5876):661-664. PMID: 18388260. [DOI Article]

September 15, 2008
Presenter: Apollina Goel
Paper: Hussain SP, He P, Subleski J, Hofseth LJ, Trivers GE, Mechanic L, Hofseth AB, Bernard M, Schwank J, Nguyen G, Mathe E, Djurickovic D, Haines D, Weiss J, Back T, Gruys E, Laubach VE, Wiltrout RH, Harris CC. (2008) Nitric oxide is a key component in inflammation-accelerated tumorigenesis. Cancer Res. 68(17):7130-7136.
PMID: 18757428 [DOI Article]

September 22, 2008
Presenter: Rick Domann
Paper: Cervera AM, Apostolova N, Crespo FL, Mata M, McCreath KJ. (2008) Cells silenced for SDHB expression display characteristic features of the tumor phenotype.
Cancer Res. 68(11):4058-4067. PMID: 18519664 [DOI Article]

September 29, 2008
Presenter: Christine Weydert
Paper: Padera TP, Kuo AH, Hoshida T, Liao S, Lobo J, Kozak KR, Fukumura D, Jain RK. (2008) Differential response of primary tumor versus lymphatic metastasis to VEGFR-2 and VEGFR-3 kinase inhibitors cediranib and vandetanib. Mol Cancer Ther. 7(8):2272-2279. PMID: 18687659 [DOI Article]

October 6, 2008
Presenter: Dr. Nukhet Aykin-Burns
Paper: Schieke SM, Ma M, Cao L, McCoy JP Jr, Liu C, Hensel NF, Barrett AJ, Boehm M, Finkel T. (2008) Mitochondrial metabolism modulates differentiation and teratoma formation capacity in mouse embryonic stem cells. J Biol Chem. 2008 Aug 18. [Epub ahead of print] PMID: 18713735 [DOI Article]

October 13, 2008
Presenter: Janice Wang
Paper: Wei Y, Pattingre S, Sinha S, Bassik M, Levine B. (2008) JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy. Mol Cell. 30:678-688. PMID: 18570871 [DOI Article]

October 20, 2008
Presenter: canceled

October 27, 2008
Presenter: Leena Chaudhuri
Paper: NM Reddy1, SR Kleeberger2, JH Bream3, PG Fallon3, TW Kensler1, M Yamamoto4 and SP Reddy1 (2008) Genetic disruption of the Nrf2 compromises cell-cycle progression by impairing GSH-induced redox signaling. Oncogene 27:5821-5832. PMID: 18542053 [DOI Article]

November 3, 2008
Presenter: Tony Cyr
Paper: Lee, SH, Kim, J, and Lee, YM. (2006) Hypoxic silencing of tumor suppressor RUNX3 by histone modification in gastric cancer cells. Oncogene. [Epub ahead of print] PMID: 18850007 [DOI Article]

November 10, 2008
Presenter: Jordan Witmer
Paper: Meaburn KJ, Misteli T. (2008) Locus-specific and activity-independent gene repositioning during early tumorgenesis. J Cell Biol. 180(1):39-50. PMID: 18195100 [DOI Article ]

November 17, 2008
Presenter: Maneesh Kumar
Paper: Liyun Sang, Hilary A. Coller, James M. Roberts. (2008) Control of the reversibility of cellular quiescence by the transcriptional repressor HES1. Science 321(5892): 1095-1100 PMID: 18719287 [DOI Article]

November 24, 2008
Presenter: Thanksgiving Week, No Journal Club

December 1, 2008
Presenter: Melissa Fath
Paper: Nannette Jelluma, Xiaodong Yang, David Stokoe, Gerard I. Evan,
Tobias B. Dansen, and Daphne A. Haas-Kogan (2006) Glucose Withdrawal Induces Oxidative Stress followed by Apoptosis in Glioblastoma Cells but not in Normal Human Astrocytes. Mol Cancer Res 4(5):319-330. PMID: 16687487. [DOI Article ]

December 8, 2008
Presenter: Adam Case
Paper: Ben Sahra I, Laurent K, Loubat A, Giorgetti-Peraldi S, Colosetti P, Auberger P, Tanti JF, Le Marchand-Brustel Y, Bost F (2008) The Antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 Level. Oncogene 27(25):3576-86 PMID: 18212742 [DOI Article]