CURRENT TOPICS IN RADIATION AND CANCER BIOLOGY (77:548)

The University of Iowa

Fall 2009

11:30-12:30, Mondays

Room B180, Med Labs

Contact: apollina-goel@uiowa.edu Tel 319-384-4754

Presentations for Fall 2009:

August 24, 2009
Presenter: Tony Cyr
Paper: Hao HX, Khalimonchuk O, Schraders M, Dephoure N, Bayley JP, Kunst H, Devilee P, Cremers CW, Schiffman JD, Bentz BG, Gygi SP, Winge DR, Kremer H, Rutter J. (2009) Sdh5, a gene required for flavination of succinate dehydrogenase, is mutated in paraganglioma. Science. PMID: 19628817. [DOI Article]

August 31, 2009
Presenter: Dr. Prabhat Goswami
Paper: Suzuki HI, Yamagata K, Sugimoto K, Iwamoto T, Kato S, Miyazono K. (2009) Modulation of microRNA processing by p53. Nature. 460(7254):529-33. [DOI Article]

September 7, 2009
Presenter: Labor Day, No Journal Club
Paper:

September 14, 2009
Presenter: Adam Case
Paper: Green DJ, Pagel JM, Nemecek ER, Lin Y, Kenoyer A, Pantelias A, Hamlin DK, Wilbur DS, Fisher DR, Rajendran JG, Gopal AK, Park SI, Press OW. (2009) Pretargeting CD45 enhances the selective delivery of radiation to hematolymphoid tissues in nonhuman primates. Blood. 114(6):1226-35. [DOI Article]

September 21, 2009
Presenter: Jim Jacobus
Paper: Maida Y, Yasukawa M, Furuuchi M, Lassmann T, Possemato R, Okamoto N, Kasim V, Hayashizaki Y, Hahn WC, Masutomi K. (2009) An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA. Nature. [Epub ahead of print] [DOI Article]

September 28, 2009
Presenter: Yueming Zhu
Paper: Zhong D, Xiong L, Liu T, Liu X, Liu X, Chen J, Sun SY, Khuri FR, Zong Y, Zhou Q, Zhou W. (2009) The glycolytic inhibitor 2-deoxyglucose activates multiple prosurvival pathways through IGF1R. J Biol Chem. 284(35):23225-33. [DOI Article]

October 5, 2009
Presenter: Weipeng Bian
Paper: Lee JY, Jung HJ, Song IS, Williams MS, Choi C, Rhee SG, Kim J, Kang SW. (2009) Protective role of cytosolic 2-cys peroxiredoxin in the TNF-alpha-induced apoptotic death of human cancer cells. Free Radic Biol Med. 2009 Oct 15;47(8):1162-71. [DOI Article]

October 12, 2009
Presenter: Dr. Douglas Spitz
Paper: Yazdanpanah B, Wiegmann K, Tchikov V, Krut O, Pongratz C, Schramm M, Kleinridders A, Wunderlich T, Kashkar H, Utermöhlen O, Brüning JC, Schütze S, Krönke M. (2009) Riboflavin kinase couples TNF receptor 1 to NADPH oxidase. Nature. [Epub ahead of print] [DOI Article]

October 19, 2009
Presenter: Leena Chaudhuri
Paper: Sandberg R, Neilson JR, Sarma A, Sharp PA, Burge CB. (2008) Proliferating cells express mRNAs with shortened 3' untranslated regions and fewer microRNA target sites. Science. 320(5883):1643-7. [DOI Article]

October 26, 2009
Presenter: Dr. Nukhet Aykin-Burns
Paper: Jian Yuan, Katherine Minter-Dykhouse, and Zhenkun Lou. (2009) A c-Myc–SIRT1 feedback loop regulates cell growth and transformation. J Cell Biol. 185(2):203-11. [DOI Article]

November 2, 2009
Presenter: Lauren Wegman
Paper: Trimboli AJ, Cantemir-Stone CZ, Li F, Wallace JA, Merchant A, Creasap N, Thompson JC, Caserta E, Wang H, Chong JL, Naidu S, Wei G, Sharma SM, Stephens JA, Fernandez SA, Gurcan MN, Weinstein MB, Barsky SH, Yee L, Rosol TJ, Stromberg PC, Robinson ML, Pepin F, Hallett M, Park M, Ostrowski MC, Leone G. (2009) Pten in stromal fibroblasts suppresses mammary epithelial tumours. Nature. 461(7267):1084-91. [DOI Article]

November 9, 2009
Presenter: Arya Sobhakumari
Paper: Guo D, Hildebrandt IJ, Prins RM, Soto H, Mazzotta MM, Dang J, Czernin J, Shyy JY, Watson AD, Phelps M, Radu CG, Cloughesy TF, Mischel PS. (2009) The AMPK agonist AICAR inhibits the growth of EGFRvIII-expressing glioblastomas by inhibiting lipogenesis. Proc Natl Acad Sci U S A. 106(31):12932-7. [DOI Article]

November 16, 2009
Presenter: Dr. Nabin C. Barua
Paper: Chemical modifications of paclitaxel and artemisinin derived antimalarial drugs: potential applications in cancer therapy

November 23, 2009
Presenter: Thanksgiving Week, No Journal Club
Paper:

November 30, 2009
Presenter: Jordan Witmer
Paper: Wang SP, Wang WL, Chang YL, Wu CT, Chao YC, Kao SH, Yuan A, Lin CW, Yang SC, Chan WK, Li KC, Hong TM, Yang PC. (2009) p53 controls cancer cell invasion by inducing the MDM2-mediated degradation of Slug. Nat Cell Biol. 11(6):694-704. [DOI Article]

December 7, 2009
Presenter: Mitch Coleman
Paper: De Boo S, Kopecka J, Brusa D, Gazzano E, Matera L, Ghigo D, Bosia A, Riganti C. (2009) iNOS activity is necessary for the cytotoxic and immunogenic effects of doxorubicin in human colon cancer cells. Mol Cancer. 8(1):108. [DOI Article]