CURRENT TOPICS IN RADIATION AND CANCER BIOLOGY (77:548)

The University of Iowa

Fall 2013

11:30-12:30, Every other Monday

Room B180, Med Labs

Contact: apollina-goel@uiowa.edu Tel 319-384-4754

Presentations for Fall 2013:

October 28, 2013
Presenter: Kyle Kloepping
Paper: Patra KC, Wang Q, Bhaskar PT, Miller L, Wang Z, Wheaton W, Chandel N, Laakso M, Muller WJ, Allen EL, Jha AK, Smolen GA, Clasquin MF, Robey RB, Hay N.
(2013) Hexokinase 2 is required for tumor initiation and maintenance and its systemic deletion is therapeutic in mouse models of cancer. Cancer Cell. 2013 Aug 12;24(2):213-28. doi:10.1016/j.ccr.2013.06.014. Epub 2013 Aug 1. PMID:23911236 PMCID:PMC3753022
[DOI Link]

November 11, 2013
Presenter: Jessica Reedy
Paper: Rizwan Haq, Jonathan Shoag, Pedro Andreu-Perez, Satoru Yokoyama, Hannah Edelman, Glenn C. Rowe, Dennie T. Frederick, Aeron D. Hurley, Abhinav Nellore, Andrew L. Kung, Jennifer A. Wargo, Jun S. Song, David E. Fisher, Zolt Arany, Hans R. Widlund. (2013) Oncogenic BRAF regulates oxidative metabolism via PGC1α and MITF. Cancer Cell. 2013 March 18; 23 (3): 302-315.
[DOI Link]

November 25, 2013
Presenter: No Journal Club, Thanksgiving

December 9, 2013
Presenter: Jyungmean Son
Paper: Achyut BR, Bader DA, Robles AI, Wangsa D, Harris CC, Ried T, Yang L. (2013) Inflammation-mediated genetic and epigenetic alterations drive cancer development in the neighboring epithelium upon stromal abrogation of TGF-β signaling. PLoS Genet. 2013;9(2):e1003251. PMID:23408900.
[DOI Link]

September 2, 2013
Presenter: Labor Day, no journal club

Sept 16, 2013
Presenter: Dr. C. Mike Knudson
Paper: Quinn BJ, Dallos M, Kitagawa H, Kunnumakkara AB, Memmott RM, Hollander MC, Gills JJ, Dennis PA.(2013) Inhibition of lung tumorigenesis by metformin is associated with decreased plasma igf-I and diminished receptor tyrosine kinase signaling. Cancer Prev Res (Phila). 6(8):801-10.
[DOI Link ]

September 30, 2013
Presenter: John Lafin
Paper: Mercier I, Camacho J, Titchen K, Gonzales DM, Quann K, Bryant KG, Molchansky A, Milliman JN, Whitaker-Menezes D, Sotgia F, Jasmin JF, Schwarting R, Pestell RG, Blagosklonny MV, Lisanti MP. (2012) Caveolin-1 and accelerated host aging in the breast tumor microenvironment: chemoprevention with rapamycin, an mTOR inhibitor and anti-aging drug. Am J Pathol. 2012 Jul;181(1):278-93. doi: 10.1016/j.ajpath.2012.03.017. Epub 2012 Jun 13.
[DOI Link]

October 14, 2013
Presenter: Josh Schoenfeld
Paper: Mishalian I, Bayuh R, Levy L, Zolotarov L, Michaeli J, Fridlender ZG. Tumor-associated neutrophils (TAN) develop pro-tumorigenic properties during tumor progression. Cancer Immunol Immunother. 2013 Oct 4. [Epub ahead of print]
[Text Link]