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Fall 2020
Cancer Biology Journal Club, The University of Iowa
Fall 2019, 11:30-12:30, Every Other Monday, Room B180 ML Conference Room
Contact: douglas-spitz@uiowa.edu Tel 319/335-8019
Zoom Meeting: https://uiowa.zoom.us/j/96891428453?pwd=UmR6bWdqeXR2MnBjbWV3Tk1neWx5dz09
Meeting ID: 968 9142 8453
August 24, 2020
Presenter: Emily Steinbach
Paper: Meng XM, Ren GL, Gao L, Yang Q, Li HD, Wu WF, Huang C, Zhang L, Lv XW, Li J. NADPH oxidase 4 promotes cisplatin-induced acute kidney injury via ROS-mediated programmed cell death and inflammation. Lab Invest. 2018 Jan;98(1):63-78. Epub 2017 Nov 6. PMID: 29106395.
doi: 10.1038/labinvest.2017.120.
September 7, 2020
Presenter: No journal club, Labor Day
September 21, 2020
Presenter: Yousuf Ali
Paper: Zhou W, Yao Y, Scott AJ, Wilder-Romans K, Dresser JJ, Werner CK, Sun H, Pratt D, Sajjakulnukit P, Zhao SG, Davis M, Nelson BS, Halbrook CJ, Zhang L, Gatto F, Umemura Y, Walker AK, Kachman M, Sarkaria JN, Xiong J, Morgan MA, Rehemtualla A, Castro MG, Lowenstein P, Chandrasekaran S, Lawrence TS, Lyssiotis CA, Wahl DR. Purine metabolism regulates DNA repair and therapy resistance in glioblastoma. Nat Commun. 2020 Jul 30;11(1):3811. PMID: 32732914; PMCID: PMC7393131.
doi: 10.1038/s41467-020-17512-x.
October 5, 2020
Presenter: Maddie Hines
Paper: Shrishrimal S, Chatterjee A, Kosmacek EA, Davis PJ, McDonald JT, Oberley-Deegan RE. Manganese porphyrin, MnTE-2-PyP, treatment protects the prostate from radiation-induced fibrosis (RIF) by activating the NRF2 signaling pathway and enhancing SOD2 and sirtuin activity. Free Radic Biol Med. 2020 May 20;152:255-270. Epub 2020 Mar 25. PMID: 32222469; PMCID: PMC7276298.
doi: 10.1016/j.freeradbiomed.2020.03.014
October 19, 2020
Presenter: Dr. Douglas R. Spitz
Paper: Smith ALM, Whitehall JC, Bradshaw C, Gay D, Robertson F, Blain AP, Hudson G, Pyle A, Houghton D, Hunt M, Sampson JN, Stamp C, Mallett g, Amarnath S, Leslie J, Oakley F, Wilson L, Baker A, Russell OM, Johnson R, Richardson CA, Gupta B, McCallum I, McDonald SAC, Kelly S, Mathers JC, Heer R, Taylor RW, Perkins ND, Turnbull DM, Sansom OJ, Greaves LC. Age-associated mitochondrial DNA mutations cause metabolic remodeling that contributes to accelerated intestinal tumorigenesis. Nature Cancer. Sept 2020.
htts://doi.org/10.1038/s43018-020-00112-5
November 2, 2020
Presenter: Tyler Atagozli
Paper: Fishel ML, Xia H, McGeown J, McIlwain DW, Elbanna M, Craft AA, Kaimakliotis HZ, Sandusky GE, Zhang C, Pili R, Kelley MR, Jerde TJ. Antitumor Activity and Mechanistic Characterization of APE1/Ref-1 Inhibitors in Bladder Cancer. Mol Cancer Ther. 2019 Nov;18(11):1947-1960. Epub 2019 Aug 14. PMID: 31413178; PMCID: PMC6844258.
doi: 10.1158/1535-7163.MCT-18-1166
November 16, 2020
Presenter: Dr. Melissa Fath
Paper: Camiolo G, Barbato A, Giallongo C, Vicario N, Romano A, Parrinello NL, Parenti R, Sandoval JC, García-Moreno D, Lazzarino G, Avola R, Palumbo GA, Mulero V, Li Volti G, Tibullo D, Di Raimondo F. Iron regulates myeloma cell/macrophage interaction and drives resistance to bortezomib. Redox Biol. 2020 Sep;36:101611. Epub 2020 Jun 24. PMID: 32863212; PMCID: PMC7327252.
doi: 10.1016/j.redox.2020.101611
November 30, 2020
Presenter: Dr. Ann Miller
Paper: Wu JY, Huang TW, Hsieh YT, Wang YF, Yen CC, Lee GL, Yeh CC, Peng YJ, Kuo YY, Wen HT, Lin HC, Hsiao CW, Wu KK, Kung HJ, Hsu YJ, Kuo CC. Cancer-Derived Succinate Promotes Macrophage Polarization and Cancer Metastasis via Succinate Receptor. Mol Cell. 2020 Jan 16;77(2):213-227.e5. Epub 2019 Nov 14. PMID: 31735641.
doi: 10.1016/j.molcel.2019.10.023