Cancer Biology Journal Club, The University of Iowa
Fall 2021, 11:30-12:30, Every Other Monday, Room B180, Med Labs
Contact: Tel 319/335-8019

August 23, 2021
Presenter:  Emily Steinbach
Paper:  Zhao S, Wang X, Zheng X, Liang X, Wang Z, Zhang J, Zhao X, Zhuang S, Pan Q, Sun F, Shang W, Barasch J, Qiu A. Iron deficiency exacerbates cisplatin- or rhabdomyolysis-induced acute kidney injury through promoting iron-catalyzed oxidative damage. Free Radic Biol Med. 2021 Jul 21;173:81-96. Epub ahead of print. PMID: 34298093.
doi: 10.1016/j.freeradbiomed.2021.07.025

September 6, 2021
Presenter:  No journal club, Labor Day

September 20, 2021
Presenter: Dr. Gloria Chen
Paper:  Ye LF, Chaudhary KR, Zandkarimi F, Harken AD, Kinslow CJ, Upadhyayula PS, Dovas A, Higgins DM, Tan H, Zhang Y, Buonanno M, Wang TJC, Hei TK, Bruce JN, Canoll PD, Cheng SK, Stockwell BR. Radiation-Induced Lipid Peroxidation Triggers Ferroptosis and Synergizes with Ferroptosis Inducers. ACS Chem Biol. 2020 Feb 21;15(2):469-484. Epub 2020 Jan 14. PMID: 31899616; PMCID: PMC7180072. 
doi: 10.1021/acschembio.9b00939

October 4, 2021
Presenter: Mike Liman
Paper: Kishimoto S, Brender JR, Chandramouli GVR, Saida Y, Yamamoto K, Mitchell JB, Krishna MC. Hypoxia-Activated Prodrug Evofosfamide Treatment in Pancreatic Ductal Adenocarcinoma Xenografts Alters the Tumor Redox Status to Potentiate Radiotherapy. Antioxid Redox Signal. 2020 Sep 15. Epub ahead of print. PMID: 32787454. 
doi: 10.1089/ars.2020.8131

October 18, 2021
Presenter:  Dr. Ali Razzaghi
Paper: Hanamshet K, Mazin AV. The function of RAD52 N-terminal domain is essential for viability of BRCA-deficient cells. Nucleic Acids Res. 2020 Dec 16;48(22):12778-12791. PMID: 33275133; PMCID: PMC7736796.
doi: 10.1093/nar/gkaa1145

November 1, 2021
Presenter:  Yuna Bayanbold
Paper: Schwartz AJ, Goyert JW, Solanki S, Kerk SA, Chen B, Castillo C, Hsu PP, Do BT, Singhal R, Dame MK, Lee HJ, Spence JR, Lakhal-Littleton S, Heiden MGV, Lyssiotis CA, Xue X, Shah YM. Hepcidin sequesters iron to sustain nucleotide metabolism and mitochondrial function in colorectal cancer epithelial cells. Nat Metab. 2021 Jul;3(7):969-982. Epub 2021 Jun 21. PMID: 34155415; PMCID: PMC8316354.
doi: 10.1038/s42255-021-00406-7

November 15, 2021
Presenter:  Laura Pietrok
Paper: Morrissey SM, Zhang F, Ding C, Montoya-Durango DE, Hu X, Yang C, Wang Z, Yuan F, Fox M, Zhang HG, Guo H, Tieri D, Kong M, Watson CT, Mitchell RA, Zhang X, McMasters KM, Huang J, Yan J. Tumor-derived exosomes drive immunosuppressive macrophages in a pre-metastatic niche through glycolytic dominant metabolic reprogramming. Cell Metab. 2021 Oct 5;33(10):2040-2058.e10. Epub 2021 Sep 23. PMID: 34559989; PMCID: PMC8506837.
doi: 10.1016/j.cmet.2021.09.002

November 29, 2021
Presenter:  Mekhla Singhania
Paper: Mao C, Liu X, Zhang Y, Lei G, Yan Y, Lee H, Koppula P, Wu S, Zhuang L, Fang B, Poyurovsky MV, Olszewski K, Gan B. DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer. Nature. 2021 May;593(7860):586-590. Epub 2021 May 12. Erratum in: Nature. 2021 Aug;596(7873):E13. PMID: 33981038.
doi: 10.1038/s41586-021-03539-7