Cancer Biology Journal Club, The University of Iowa
Fall 2022, 11:30-12:30, Every Other Monday, Room B180, Med Labs
Contact: douglas-spitz@uiowa.edu Tel 319/335-8019

August 22, 2022

Presenter: Ali Razzaghi

Paper: Skoko JJ, Cao J, Gaboriau D, Attar M, Asan A, Hong L, Paulsen CE, Ma H, Liu Y, Wu H, Harkness T, Furdui CM, Manevich Y, Morrison CG, Brown ET, Normolle D, Spies M, Spies MA, Carroll K, Neumann CA. Redox regulation of RAD51 Cys319 and homologous recombination by peroxiredoxin 1. Redox Biol. 2022 Oct;56:102443. Epub 2022 Aug 24. PMID: 36058112; PMCID: PMC9450138.

doi: 10.1016/j.redox.2022.102443

September 5, 2022

Presenter: No journal club, Labor Day

Paper: 

September 19, 2022

Presenter:  Mekhla Singhania

Paper:  Kishimoto S, Brender JR, Chandramouli GVR, Saida Y, Yamamoto K, Mitchell JB, Krishna MC. Hypoxia-Activated Prodrug Evofosfamide Treatment in Pancreatic Ductal Adenocarcinoma Xenografts Alters the Tumor Redox Status to Potentiate Radiotherapy. Antioxid Redox Signal. 2021 Oct 10;35(11):904-915. Epub 2020 Sep 15. PMID: 32787454; PMCID: PMC8568781.

doi: 10.1089/ars.2020.8131

October 3, 2022

Presenter: Sunny Huang
Paper: Kurz E, Hirsch CA, Dalton T, Shadaloey SA, Khodadadi-Jamayran A, Miller G, Pareek S, Rajaei H, Mohindroo C, Baydogan S, Ngo-Huang A, Parker N, Katz MHG, Petzel M, Vucic E, McAllister F, Schadler K, Winograd R, Bar-Sagi D. Exercise-induced engagement of the IL-15/IL-15Rα axis promotes anti-tumor immunity in pancreatic cancer. Cancer Cell. 2022 Jul 11;40(7):720-737.e5. Epub 2022 Jun 2. PMID: 35660135; PMCID: PMC9280705. 

doi: 10.1016/j.ccell.2022.05.006

October 17, 2022

Presenter: Kyle Current

Paper: Ye Q, Zhang Y, Cao Y, Wang X, Guo Y, Chen J, Horn J, Ponomareva LV, Chaiswing L, Shaaban KA, Wei Q, Anderson BD, St Clair DK, Zhu H, Leggas M, Thorson JS, She QB. Frenolicin B Targets Peroxiredoxin 1 and Glutaredoxin 3 to Trigger ROS/4E-BP1-Mediated Antitumor Effects. Cell Chem Biol. 2019 Mar 21;26(3):366-377.e12. Epub 2019 Jan 17. PMID: 30661989; PMCID: PMC6557261.

doi: 10.1016/j.chembiol.2018.11.013

October 31, 2022

Presenter:  Michelle Giedt

Paper: Loo SY, Toh LP, Xie WH, Pathak E, Tan W, Ma S, Lee MY, Shatishwaran S, Yeo JZZ, Yuan J, Ho YY, Peh EKL, Muniandy M, Torta F, Chan J, Tan TJ, Sim Y, Tan V, Tan B, Madhukumar P, Yong WS, Ong KW, Wong CY, Tan PH, Yap YS, Deng LW, Dent R, Foo R, Wenk MR, Lee SC, Ho YS, Lim EH, Tam WL. Fatty acid oxidation is a druggable gateway regulating cellular plasticity for driving metastasis in breast cancer. Sci Adv. 2021 Oct 8;7(41):eabh2443. Epub 2021 Oct 6. PMID: 34613780; PMCID: PMC8494440. 

doi: 10.1126/sciadv.abh2443

November 14, 2022

Presenter: Canceled

November 28, 2022

Presenter: Canceled