CURRENT TOPICS IN RADIATION AND CANCER BIOLOGY (FRRB:6008)
SCHEDULE OF PRESENTATIONS
Fall 2023 (Director: Dr. Douglas Spitz)
11:30 AM - 12.30 PM EVERY OTHER MONDAY IN ROOM B180 ML 

Presentations for Fall 2023:

Monday, August 21, 2023

Presenter: Amanda Pope
Paper: Peng F, Xu Q, Jing X, Chi X, Zhang Z, Meng X, Liu X, Yan J, Liu X, Shao S. GPX2 promotes EMT and metastasis in non-small cell lung cancer by activating PI3K/AKT/mTOR/Snail signaling axis. FASEB Bioadv. 2023 Apr 8;5(6):233-250. PMID: 37287867; PMCID: PMC10242197. doi: 10.1096/fba.2022-00045.

Monday, September 4, 2023 LABOR DAY
NO JOURNAL CLUB

Monday, September 18, 2023

Presenter: Douglas Spitz
Paper: Aurora AB, Khivansara V, Leach A, Gill JG, Martin-Sandoval M, Yang C, Kasitinon SY, Bezwada D, Tasdogan A, Gu W, Mathews TP, Zhao Z, DeBerardinis RJ, Morrison SJ. Loss of glucose 6-phosphate dehydrogenase function increases oxidative stress and glutaminolysis in metastasizing melanoma cells. Proc Natl Acad Sci U S A. 2022 Feb 8;119(6):e2120617119. PMID: 35110412; PMCID: PMC8833200. doi: 10.1073/pnas.2120617119.

Monday, October 2, 2023

Presenter: Akshaya Warrier 
Paper: Ding H, Chen Z, Wu K, Huang SM, Wu WL, LeBoeuf SE, Pillai RG, Rabinowitz JD, Papagiannakopoulos T. Activation of the NRF2 antioxidant program sensitizes tumors to G6PD inhibition. Sci Adv. 2021 Nov 19;7(47):eabk1023. doi: 10.1126/sciadv.abk1023. Epub 2021 Nov 17. PMID: 34788087; PMCID: PMC8598006.

Monday, October 16, 2023

Presenter: Kyle Current
Paper: Tomczyk MM, Cheung KG, Xiang B, Tamanna N, Fonseca Teixeira AL, Agarwal P, Kereliuk SM, Spicer V, Lin L, Treberg J, Tong Q, Dolinsky VW. Mitochondrial Sirtuin-3 (SIRT3) Prevents Doxorubicin-Induced Dilated Cardiomyopathy by Modulating Protein Acetylation and Oxidative Stress. Circ Heart Fail. 2022 May;15(5):e008547. doi: 10.1161/CIRCHEARTFAILURE.121.008547. Epub 2022 Apr 14. PMID: 35418250; PMCID: PMC9117478.

Monday, October 30, 2023

Presenter: Sunny Huang
Paper: Maas RR, Soukup K, Fournier N, Massara M, Galland S, Kornete M, Wischnewski V, Lourenco J, Croci D, Álvarez-Prado ÁF, Marie DN, Lilja J, Marcone R, Calvo GF, Santalla Mendez R, Aubel P, Bejarano L, Wirapati P, Ballesteros I, Hidalgo A, Hottinger AF, Brouland JP, Daniel RT, Hegi ME, Joyce JA. The local microenvironment drives activation of neutrophils in human brain tumors. Cell. 2023 Oct 12;186(21):4546-4566.e27. doi: 10.1016/j.cell.2023.08.043. Epub 2023 Sep 27. PMID: 37769657.

Monday, November 13, 2023

Presenter: Ali Razzaghi
Paper: Fu Y, Sacco O, DeBitetto E, Kanshin E, Ueberheide B, Sfeir A. Mitochondrial DNA breaks activate an integrated stress response to reestablish homeostasis. Mol Cell. 2023 Oct 19;83(20):3740-3753.e9. doi: 10.1016/j.molcel.2023.09.026. Epub 2023 Oct 12. PMID: 37832546.

Monday, November 27, 2023

Presenter: Casey Pulliam
Paper: Koppula P, Lei G, Zhang Y, Yan Y, Mao C, Kondiparthi L, Shi J, Liu X, Horbath A, Das M, Li W, Poyurovsky MV, Olszewski K, Gan B. A targetable CoQ-FSP1 axis drives ferroptosis- and radiation-resistance in KEAP1 inactive lung cancers. Nat Commun. 2022 Apr 22;13(1):2206. doi: 10.1038/s41467-022-29905-1. PMID: 35459868; PMCID: PMC9033817.

Monday, December 11, 2023 FINALS WEEK
NO JOURNAL CLUB