The University of Iowa

Spring 2006

11:30-12:30, Mondays

Room B180, Med Labs

Contact: Tel 319-384-4754

January 23, 2006
Presenter: Dr. Prabhat Goswami
Paper: Hu Y, Rosen DG, Zhou Y, et al. (2005) Mitochondrial Manganese-Superoxide Dismutase Expression in Ovarial Cancer; Role in Cell Proliferation and Response to Oxidative Stress. Journal of Biological Chemistry 280(47):39485-39492.[DOI Article]

January 30, 2006
Presenter: Ann Simons
Paper: Xu RH, Pelicano H, Zhou Y, et al. (2005) Inhibition of Glycolysis in Cancer Cells: A Novel Strategy to Overcome Drug Resistance Associated with Mitochondrial Respiratory Defect and Hypoxia. Cancer Research 65(2):613-621, [DOI Article]

February 6, 2006
Presenter: Hualei Li
Paper: Mitchell DC, Abdelrahim M, Weng J, et al. (2006) Regulation of KiSS-1 metastasis suppressor gene expression in breast cancer cells by direct interaction of transcription factors activator protein-2alpha and specificity protein-1. J Biol Chem. 281(1):51-8.[DOI Article]

February 13, 2006
Presenter: Rick Domann
Paper: Emerling BM, Platanias LC, Black E, et al. (2005) Mitochondrial reactive oxygen species activation of p38 mitogen-activated protein kinase is required for hypoxia signaling. Mol Cell Biol. 25(12):4853-62.[DOI Article]

February 20, 2006
Presenter: Sarita Menon
Paper: Iwata J, Ezaki J, Komatsu M, et al. (2006) Excess peroxisomes are degraded by autophagic machinery in mammals. J Biol Chem. 281(7):4035-4041.[DOI Article]

February 27, 2006
Presenter:Melissa Fath
Paper: Kim H, Kim EH, Eom YW, et al. (2006) Sulforaphane sensitizes tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant hepatoma cells to TRAIL-induced apoptosis through reactive oxygen species-mediated up-regulation of DR5. Cancer Res. 66(3):1740-50.[DOI Article]

March 6, 2006
Presenter: Oksana Zagorodna
Paper: Quintero M, Brennan PA, Thomas GJ, et al. (2006) Nitric oxide is a factor in the stabilization of hypoxia-inducible factor-1alpha in cancer: role of free radical formation. Cancer Res. 66(2):770-4. [DOI Article]

March 13, 2006
Presenter: Spring Break, No Journal Club

March 20, 2006
Presenter: Kjerstin Owens
Paper: McCabe MT, Low JA, Daignault S, et al. (2006) Inhibition of DNA methyltransferase activity prevents tumorigenesis in a mouse model of prostate cancer. Cancer Res. 66(1):385-92.[DOI Article]

March 27, 2006
Presenter: Kim Krager
Paper: Miccadei S, Provenzano C, Mojzisek M, et al. (2005) Retinoblastoma protein acts as Pax 8 transcriptional coactivator. Oncogene 24(47):6993-7001.[DOI Article]

April 3, 2006
Presenter: Suwimol Jetawattana
Paper: Natarajan R, Salloum FN, Fisher BJ, Kukreja RC, Fowler AA 3rd. (2006) Hypoxia inducible factor-1 activation by prolyl 4-hydroxylase-2 gene silencing attenuates myocardial ischemia reperfusion injury. Circ Res. 98(1):133-40.[DOI Article]

April 10, 2006
Presenter: Tanja Hadzic
Paper: Thorne SH, Negrin RS, and Contag CH. (2006) Synergistic Antitumor Effects of Immune Cell-Viral Biotherapy. Science 311(5768):1780-1784.[DOI Article]

April 17, 2006
Presenter: Chang-Ming Chen
Paper: Ran Q, Liang H, Gu M, et al. (2004) Transgenic mice overexpressing glutathione peroxidase 4 are protected against oxidative stress-induced apoptosis. J Biol Chem. 279(53):55137-46.[DOI Article]

April 24, 2006
Presenter: Douglas Spitz
Paper: Xavier S, Piek E, Fujii M, Javelaud D, et al. (2004) Amelioration of radiation-induced fibrosis: inhibition of transforming growth factor-beta signaling by halofuginone. J Biol Chem. 279(15):15167-76.[DOI Article]

May 1, 2006
Presenter: Ehab Sarsour
Paper: Quintero M, Colombo SL, Godfrey A, and Moncada S. (2006) Mitochondria as signaling organelles in the vascular endothelium. Proc Natl Acad Sci U S A. 103(14):5379-84.[DOI Article]