The University of Iowa

Spring 2008

11:30-12:30, Mondays

Room B180, Med Labs

Contact: Tel 319-384-4754
January 28, 2008
Presenter: Oksana Zagorodna
Paper: Kurtoglu M, Gao N, Shang J, Maher JC, Lehrman MA, Wangpaichitr M, Savaraj N, Lane AN, Lampidis TJ. (2007) Under normoxia, 2-deoxy-D-glucose elicits cell death in select tumor types not by inhibition of glycolysis but by interfering with N-linked glycosylation. Mol Cancer Ther. 6(11):3049-3058. [DOI Article]

February 4, 2008
Presenter: Mike Hitchler
Paper: Nowacki M, Vijayan V, Zhou Y, Schotanus K, Doak TG, Landweber LF. (2008) RNA-mediated epigenetic programming of a genome-rearrangement pathway. Nature. 451(7175):153-158.[DOI Article]

February 11, 2008
Presenter: Maneesh Kumar
Paper: Tavazoie SF, Alarcón C, Oskarsson T, Padua D, Wang Q, Bos PD, Gerald WL, Massagué J. (2008) Endogenous human microRNAs that suppress breast cancer metastasis. Nature. 451(7175):147-152. [DOI Article]

February 18, 2008
Presenter: Leena Chaudhuri
Paper: Deniaud A, Sharaf el dein O, Maillier E, Poncet D, Kroemer G, Lemaire C, Brenner C. (2008) Endoplasmic reticulum stress induces calcium-dependent permeability transition, mitochondrial outer membrane permeabilization and apoptosis. Oncogene. 27(3):285-299. [DOI Article]

February 25, 2008
Presenter: Yueming Zhu
Paper: Xia C, Meng Q, Liu LZ, Rojanasakul Y, Wang XR, Jiang BH. (2007) Reactive oxygen species regulate angiogenesis and tumor growth through vascular endothelial growth factor. Cancer Res. 67(22):10823-10830. [DOI Article]

March 3, 2008
Presenter: Jordan Witmer
Paper: Baptiste-Okoh N, Barsotti AM, Prives C. (2008) A role for caspase 2 and PIDD in the process of p53-mediated apoptosis. Proc Natl Acad Sci U S A. 105(6):1937-1942. [DOI Article]

March 10, 2008
Presenter: Janice Wang
Paper: Mathew R, Kongara S, Beaudoin B, Karp CM, Bray K, Degenhardt K, Chen G, Jin S, White E. (2007) Autophagy suppresses tumor progression by limiting chromosomal instability. Genes Dev. 21(11):1367-1381. [DOI Article]

March 17, 2008
Spring Break, no journal club

March 24, 2008
Presenter: Jennifer Nickerson-Gass
Paper: Rao AK, Ziegler YS, McLeod IX, Yates JR, Nardulli AM. (2008) Effects of Cu/Zn Superoxide Dismutase (SOD1) on Estrogen Responsiveness and Oxidative Stress in Human Breast Cancer Cells. Mol Endocrinol. Feb 7 [Epub ahead of print].

March 31, 2008
Presenter: Disha Dayal
Paper: Guzy RD, Sharma B, Bell E, Chandel NS, Schumacker PT. (2008) Loss of the SdhB, but Not the SdhA, subunit of complex II triggers reactive oxygen species-dependent hypoxia-inducible factor activation and tumorigenesis. Mol Cell Biol. 28(2):718-731.
[DOI Article]

April 7, 2008
Presenter: Amanda Kalen
Paper: Bogunovic B, Stojakovic M, Chen L, Maric M. (2008) An unexpected functional link between lysosomal thiol reductase and mitochondrial manganese superoxide dismutase. J Biol Chem. Jan 24 [Epub ahead of print]. [DOI Article]

April 14, 2008
Presenter: Dr. Nukhet Aykin-Burns
Paper: Nie C, Tian C, Zhao L, Petit PX, Mehrpour M, Chen Q. (2008) Cysteine 62 of bax is critical for its conformational activation and its pro-apoptotic activity in response to H2O2 -induced apoptosis. J Biol Chem. Mar 15 [Epub ahead of print]. [DOI Article]

April 21, 2008
Presenter: Dr. Douglas Spitz
Paper: Zhou H, Ivanov VN, Lien YC, Davidson M, Hei TK. (2008) Mitochondrial function and nuclear factor-kappaB-mediated signaling in radiation-induced bystander effects. Cancer Res. 68(7):2233-2240. [DOI Article]

April 28, 2008
Presenter: Peter Scarbrough
Paper: Yokouchi M, Hiramatsu N, Hayakawa K, Okamura M, Du S, Kasai A, Takano Y, Shitamura A, Shimada T, Yao J, Kitamura M. (2008) Involvement of selective reactive oxygen species upstream of proapoptotic branches of unfolded protein response. J Biol Chem. 283(7):4252-4260. [DOI Article]

May 5, 2008
Presenter: Cancelled, moved to Fall 2008, Josh Madsen
Paper: Ishikawa K, Takenaga K, Akimoto M, Koshikawa N, Yamaguchi A, Imanishi H, Nakada K, Honma Y, Hayashi JI. (2008) ROS-Generating Mitochondrial DNA Mutations Can Regulate Tumor Cell Metastasis. Science. [Epub ahead of print]. [DOI Article]