CURRENT TOPICS IN RADIATION AND CANCER BIOLOGY (77:548)

The University of Iowa

Spring 2009

11:30-12:30, Mondays

Room B180, Med Labs

Contact: apollina-goel@uiowa.edu Tel 319-384-4754

January 26, 2009
Presenter: Dr. Nukhet Aykin-Burns
Paper: Hempel N, Ye H, Abessi B, Mian B, Melendez JA. (2009) Altered redox status accompanies progression to metastatic human bladder cancer. Free Radic Biol Med. 46(1):42-50. PMID: 18930813
[DOI Article]

February 2, 2009
Presenter: Peter Scarbrough
Paper: Nakashima-Kamimura N, Mori T, Ohsawa I, Asoh S, Ohta S. (2009) Molecular hydrogen alleviates nephrotoxicity induced by an anti-cancer drug cisplatin without compromising anti-tumor activity in mice. Cancer Chemother Pharmacol. [Epub ahead of print] PMID: 19148645
[DOI Article]

February 9, 2009
Presenter: Jennifer Nickerson-Gass
Paper: Nogueira V, Park Y, Chen CC, Xu PZ, Chen ML, Tonic I, Unterman T, Hay N. (2008) Akt determines replicative senescence and oxidative or oncogenic premature senescence and sensitizes cells to oxidative apoptosis. Cancer Cell. 14(6):458-470. PMID: 19061837 [DOI Article]

February 16, 2009
Presenter: Yueming Zhu
Paper: Diehn M, Cho RW, Lobo NA, Kalisky T, Dorie MJ, Kulp AN, Qian D, Lam JS, Ailles LE, Wong M, Joshua B, Kaplan MJ, Wapnir I, Dirbas F, Somlo G, Garberoglio C, Paz B, Shen J, Lau SK, Quake SR, Brown JM, Weissman IL, Clarke MF. (2009) Association of reactive oxygen species levels and radioresistance in cancer stem cells. Nature. [Epub ahead of print] PMID: 19194462 [DOI Article]

February 23, 2009
Presenter: Dr. Nukhet Aykin-Burns
Paper: Lee J, Son MJ, Woolard K, Donin NM, Li A, Cheng CH, Kotliarova S, Kotliarov Y, Walling J, Ahn S, Kim M, Totonchy M, Cusack T, Ene C, Ma H, Su Q, Zenklusen JC, Zhang W, Maric D, Fine HA. (2008) Epigenetic-mediated dysfunction of the bone morphogenetic protein pathway inhibits differentiation of glioblastoma-initiating cells. Cancer Cell. 13(1):69-80. PMID: 18167341 [DOI Article]

March 2, 2009
Presenter: Dr. Frederick Domann
Paper: Sreekumar A, Poisson LM, Rajendiran TM, Khan AP, Cao Q, Yu J, Laxman B, Mehra R, Lonigro RJ, Li Y, Nyati MK, Ahsan A, Kalyana-Sundaram S, Han B, Cao X, Byun J, Omenn GS, Ghosh D, Pennathur S, Alexander DC, Berger A, Shuster JR, Wei JT, Varambally S, Beecher C, Chinnaiyan AM (2009) Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. Nature. 457(7231):910-914. [DOI Article]

Supplemental Paper: Abate-Shen C, Shen MM. (2009) Diagnostics: The prostate-cancer metabolome. Nature. 457(7231):799-800. PMID: 19212391 [DOI Article]

March 9, 2009
Presenter: Canceled

March 16, 2009
Presenter: No Meeting – Spring Break

March 23, 2009
Presenter: Jordan Witmer
Paper: Christofk HR, Vander Heiden MG, Harris MH, Ramanathan A, Gerszten RE, Wei R, Fleming MD, Schreiber SL, Cantley LC. (2008) The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth. Nature. 452(7184):230-233. PMID: 18337823 [DOI Article]

March 30, 2009
Presenter: Maneesh Kumar
Paper: Fornari F, Gramantieri L, Ferracin M, Veronese A, Sabbioni S, Calin GA, Grazi GL, Giovannini C, Croce CM, Bolondi L, Negrini M. (2008) MiR-221 controls CDKN1C/p57 and CDKN1B/p27 expression in human hepatocellular carcinoma. Oncogene. 27(43):5651-5661. PMID: 18521080 [DOI Article]

April 6, 2009
Presenter: Mitch Coleman
Paper: Liu Y, Elf SE, Miyata Y, Sashida G, Liu Y, Huang G, Di Giandomenico S, Lee JM, Deblasio A, Menendez S, Antipin J, Reva B, Koff A, Nimer SD.
(2009) p53 regulates hematopoietic stem cell quiescence. Cell Stem Cell. 4(1):37-48. [DOI Article]

April 13, 2009
Presenter: Dr. Bill Osborne
Talk: “The Thirteen International Congresses of Radiation Research Re-visited 1958-2007”

April 20, 2009
Presenter: Yunxia O'Malley
Paper: Lee DY, Deng Z, Wang CH, Yang BB. (2007) MicroRNA-378 promotes cell survival, tumor growth, and angiogenesis by targeting SuFu and Fus-1 expression Proc Natl Acad Sci U S A. 104(51):20350-20355. [DOI Article]

Supplement Paper: Lee DY, Shatseva T, Jeyapalan Z, Du WW, Deng Z, Yang BB. (2009) A 3'-untranslated region (3'UTR) induces organ adhesion by regulating miR-199a* functions. PLoS ONE. 4(2):e4527. [DOI Article]

April 27, 2009
Presenter: Tony Cyr
Paper: Zhao S, Lin Y, Xu W, Jiang W, Zha Z, Wang P, Yu W, Li Z, Gong L, Peng Y, Ding J, Lei Q, Guan KL, Xiong Y. (2009) Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha. Science. 324(5924):261-265. [DOI Article]

May 4, 2009
Presenter: Dr. Joshua Madsen
Paper: Varambally S, Cao Q, Mani RS, Shankar S, Wang X, Ateeq B, Laxman B, Cao X, Jing X, Ramnarayanan K, Brenner JC, Yu J, Kim JH, Han B, Tan P, Kumar-Sinha C, Lonigro RJ, Palanisamy N, Maher CA, Chinnaiyan AM. (2008) Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer. Science. 322(5908):1695-1699. [DOI Article]