Cancer Biology Journal ClubThe University of Iowa

Spring 2015, 11:30-12:30, MondaysRoom B180, Med Labs

Contact: Tel 319/384-4754

January 19, 2015 -- MLK Jr. Day, No Journal Club

February 2, 2015
Presenter: Dr. Apollina Goel
Paper: Leung-Hagesteijn C, Erdmann N, Cheung G, Keats JJ, Stewart AK, Reece DE, Chung KC, Tiedemann RE. Xbp1s-negative tumor B cells and pre-plasmablasts mediate therapeutic proteasome inhibitor resistance in multiple myeloma. Cancer Cell. 2013 Sep 9;24(3):289-304. doi: 10.1016/j.ccr.2013.08.009. PMCID: PMC4118579.

February 16, 2015
Presenter: John Lafin
Paper: Ibtissam Marchiq, Renaud Le Floch, Danièle Roux, Marie-Pierre Simon, and Jacques Pouyssegur. Genetic Disruption of Lactate/H+ Symporters (MCTs) and Their Subunit CD147/BASIGIN Sensitizes Glycolytic Tumor Cells to Phenformin. 2015 Jan 1;75(1):171-80. PMID: 25403912. doi: 10.1158/0008-5472.CAN-14-2260.

March 2, 2015
Presenter: Madelyn Espinosa-Cotton
Paper: Ryu YK, Lee MH, Lee J, Lee JW, Jang SJ, Kang JH, Moon EY. γ-Irradiated cancer cells promote tumor growth by activation of Toll-like receptor 1-mediated inducible nitric oxide synthase in macrophages. J Leukoc Biol. 2015 Jan 28. pii:jlb.3A0114-055R. PubMed PMID: 25632046.
[DOI Link, ].

March 16, 2015 -- SPRING BREAK, No Journal Club

March 30, 2015
Presenter: Magdalene Ameka
Paper: Planavila A, Redondo-Angulo I, Ribas F, Garrabou G, Casademont J, Giralt M, Villarroya F. Fibroblast growth factor 21 protects the heart from oxidative stress. Cardiovasc Res. 2014 Dec 23. pii: cvu263. PMID: 25538153. Doi: 10.1093/cvr/cvu263.

April 13, 2015
Presenter: Dr. Frederick Domann
Paper: Tomasetti C, Vogelstein B. Cancer etiology. Variation in cancer risk among tissues can be explained by the number of stem cell divisions. Science. 2015 Jan 2;347(6217):78-81. doi: 10.1126/science.1260825. PMID: 25554788.

April 27, 2015
Presenter: Shane Solst
Paper:  Isaac S. Harris, Aislinn E. Treloar, Satoshi Inoue, Masato Sasaki, Chiara Gorrini, Kim Chung Lee, Ka Yi Yung, Dirk Brenner, Christiane B. Knobbe-Thomsen, Maureen A. Cox, Andrew Elia, Thorsten Berger, David W. Cescon, Adewunmi Adeoye, Anne Brüstle, Sam D. Molyneux, Jacqueline M. Mason, Wanda Y. Li, Kazuo Yamamoto, Andrew Wakeham, Hal K. Berman, Rama Khokha, Susan J. Done, Terrance J. Kavanagh, Ching-Wan Lam, Tak W. Mak. Glutathione and Thioredoxin Antioxidant Pathways Synergize to Drive Cancer Initiation and Progression. Cancer Cell. February 2015;27(2):211-222.

May 11, 2015
Presenter: Joshua Schoenfeld
Paper: Obenauf AC, Zou Y, Ji AL, Vanharanta S, Shu W, Shi H, Kong X, Bosenberg MC, Wiesner T, Rosen N, Lo RS, Massagué J. Therapy-induced tumour secretomes promote resistance and tumour progression. Nature. 2015 Mar 25. doi: 10.1038/nature14336. PMID: 25807485.