Cancer Biology Journal Club, The University of Iowa

Spring 2016, 11:30-12:30, Mondays, Room B180, Med Labs

Contact: apollina-goel@uiowa.edu Tel 319/384-4754

January 18, 2016
Presenter: No Journal Club, holiday

February 1, 2016
Presenter: Kelly Falls
Paper: Lu H, Samanta D, Xiang L, Zhang H, Hu H, Chen I, Bullen JW, Semenza GL. Chemotherapy triggers HIF-1-dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype. Proc Natl Acad Sci U S A. 2015 Aug 18;112(33):E4600-9. PMID: 26229077; PMCID: PMC4547233. doi: 10.1073/pnas.1513433112.

Thursday, February 11, 2016 at 11:30am in B180 ML
Presenter: Shane Solst
Paper: Sellers K, Fox MP, Bousamra M 2nd, Slone SP, Higashi RM, Miller DM, Wang Y, Yan J, Yuneva MO, Deshpande R, Lane AN, Fan TW. Pyruvate carboxylase is critical for non-small-cell lung cancer proliferation. J Clin Invest. 2015 Feb;125(2):687-98. PMID: 25607840; PMCID: PMC4319441.
doi: 10.1172/JCI72873.

February 15, 2016
Presenter: Cameron Cushing
Paper: Zakian KL, Hatfield W, Aras O, Cao K, Yakar D, Goldman DA, Moskowitz CS, Shukla-Dave A, Tehrani YM, Fine S, Eastham J, Hricak H. Prostate MRSI Predicts Outcome in Radical Prostatectomy Patients. Magn Reson Imaging. 2016 Jan 25. pii: S0730-725X(16)00012-6. PMID: 26821278. 
doi: 10.1016/j.mri.2016.01.003.

Thursday, February 18, 2016 at 11:30am in B180 ML
Presenter: Joshua Schoefeld
Paper: Piskounova E, Agathocleous M, Murphy MM, Hu Z, Huddlestun SE, Zhao Z, Leitch AM, Johnson TM, DeBerardinis RJ, Morrison SJ. Oxidative stress inhibits distant metastasis by human melanoma cells. Nature. 2015 Nov 12;527(7577):186-91. PMID: 26466563; PMCID: PMC4644103.
doi: 10.1038/nature15726.

February 29, 2016
Presenter: Adrienne Klinger
Paper: Greenshields AL, Shepherd TG, Hoskin DW. Contribution of reactive oxygen species to ovarian cancer cell growth arrest and killing by the anti-malarial drug artesunate. Mol Carcinog. 2016 Feb 15. PMID: 26878598.
doi: 10.1002/mc.22474.

March 14, 2016
Presenter: Spring Break, No Journal Club

March 28, 2016
Presenter: Paige Kluz
Paper: Coffelt SB, Kersten K, Doornebal CW, Weiden J, Vrijland K, Hau CS, Verstegen NJ, Ciampricotti M, Hawinkels LJ, Jonkers J, de Visser KE. IL-17-producing γδ T cells and neutrophils conspire to promote breast cancer metastasis. Nature. 2015 Jun 18;522(7556):345-8. PMID: 25822788; PMCID: PMC4475637.
doi: 10.1038/nature14282.

April 11, 2015
Presenter:  Madelyn Espinosa-Cotton
Paper: Ubertini V, Norelli G, D'Arcangelo D, Gurtner A, Cesareo E, Baldari S, Gentileschi MP, Piaggio G, Nisticò P, Soddu S, Facchiano A, Bossi G. Mutant p53 gains new function in promoting inflammatory signals by repression of the secreted interleukin-1 receptor antagonist. Oncogene. 2015 May 7;34(19):2493-504. PMID: 24998848.
doi: 10.1038/onc.2014.191.

April 25, 2016
Presenter: John Lafin
Paper: Halama N, Zoernig I, Berthel A, Kahlert C, Klupp F, Suarez-Carmona M, Suetterlin T, Brand K, Krauss J, Lasitschka F, Lerchl T, Luckner-Minden C, Ulrich A, Koch M, Weitz J, Schneider M, Buechler MW, Zitvogel L, Herrmann T, Benner A, Kunz C10, Luecke S, Springfeld C, Grabe N, Falk CS, Jaeger D. Tumoral Immune Cell Exploitation in Colorectal Cancer Metastases Can Be Targeted Effectively by Anti-CCR5 Therapy in Cancer Patients. Cancer Cell. 2016 Apr 11;29(4):587-601. PMID: 27070705
doi: 10.1016/j.ccell.2016.03.005.

May 9, 2016
Presenter: Somya Kapoor
Paper: Rodrigues MF, Obre E, de Melo FH, Santos GC Jr, Galina A, Jasiulionis MG, Rossignol R, Rumjanek FD, Amoêdo ND. Enhanced OXPHOS, glutaminolysis and β-oxidation constitute the metastatic phenotype of melanoma cells. Biochem J. 2016 Mar 15;473(6):703-15. PMID: 26699902.
doi: 10.1042/BJ20150645.